Fact sheet: the Report on Carcinogens - 9...( king latex paints and textiles which h...)

king latex paints and textiles, which had been listed since 1989 as "reasonably anticipated to be a human carcinogen," was also delisted. The Basic Acrylic Monomer Manufacturers, Inc. (BAMM) had nominated ethyl acrylate for delisting, which led to a new review of the carcinogenicity data for ethyl acrylate. The review found that tumors induced in animal studies were seen only when the chemical was given by an oral route at high concentrations, resulting in persistent and severe gastric tissue injury. Because significant chronic human oral exposure to high concentrations of ethyl acrylate is unlikely, it was concluded that ethyl acrylate should not be considered "reasonably anticipated to be a human carcinogen."

The delistings of saccharin and ethyl acrylate are the first since a formal process for delisting substances from the Report was established in 1996.

Added as "known human carcinogens" or upgraded to that category in the 9th Report:

• Environmental tobacco smoke - Environmental tobacco smoke, generated from sidestream and exhaled mainstream smoke of cigarettes, pipes, and cigars is listed as a "known human carcinogen." The Report indicates this listing is based on the observed causal relationship between passive exposure to tobacco smoke and human lung cancer. The listing states that there are conclusive published studies that indicate increased risk of lung cancer in nonsmoking women living with smoking husbands or working with smoking co-workers.

• Tobacco smoking - Tobacco smoking (i.e. directly inhaled tobacco smoke) is listed as a "known human carcinogen." Cigarette smoking has been known to cause cancer in humans for many years, and is now considered to be the leading preventable cause of cancer in developed countries. Separate chemicals identified in tobacco smoke were already listed as carcinogens in the Report. The new listing of tobacco smoking is the result of the 1996 revision in the review process that allo
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Contact: Sandra Lange
lange@niehs.nih.gov
919-541-0530
NIH/National Institute of Environmental Health Sciences
14-May-2000


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