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Fact sheet: the Report on Carcinogens - 9th edition

levated lung cancer rates in occupational groups exposed to diesel exhaust. These groups include railroad workers, mine workers, bus garage workers, and trucking company workers.

  • Isoprene - Isoprene is listed in the 9th Report as "reasonably anticipated to be a human carcinogen." Isoprene is one of the major components that makes up natural rubber and is used to make synthetic rubbers. It is also emitted from plants and trees, has been detected in tobacco smoke and automobile exhaust, and was identified as a major endogenous hydrocarbon in human breath. The Report states the listing is based on findings from laboratory animal studies of isoprene where cancer was observed in multiple organ sites following long-term inhalation exposures.

  • Chloroprene - Chloroprene is listed in the 9th Report as "reasonably anticipated to be a human carcinogen." It is primarily used in the production of the elastomer polychloroprene (neoprene). The Report states the listing is based on findings from laboratory animal studies of chloroprene in which cancer was observed in multiple organs of multiple species following long-term inhalation exposures.

  • Phenolphthalein - Phenolphthalein is listed in the 9th Report as "reasonably anticipated to be a human carcinogen." It is used as a laboratory reagent and acid-base indicator and has been used in over-the-counter laxative preparations. The listing is based on findings from feeding studies of phenolphthalein that caused cancer in multiple organs in multiple species of experimental animals.

  • Tetrafluoroethylene - Tetrafluoroethylene is listed in the 9th Report as "reasonably anticipated to be a human carcinogen." It is used in the production of polytetrafluoroethylene and other polymers. The RoC states the listing is based on findings from laboratory animal studies of tetrafluoroethylene in which cancer was observed in multiple organs of multiple species following long-term inhalation exposure
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    • Contact: Sandra Lange
    lange@niehs.nih.gov
    919-541-0530
    NIH/National Institute of Environmental Health Sciences
    14-May-2000


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