HOME >> BIOLOGY >> NEWS
Factor identified that makes treating aging hearts with gene therapy difficult

Scientists at Massachusetts General Hospital (MGH) and their colleagues have found why older cardiac cells are more difficult to treat with gene therapy than younger cells. The findings, published in the May 4, 2003, issue of Circulation, have implications for therapeutic strategies aimed at the aging population.

"Efforts to develop gene therapy for heart disease have been geared towards the elderly since they have fewer therapeutic options," says principal investigator Roger Hajjar, MD, of the Cardiovascular Research Center at MGH. "Our results show that we have some hurdles to overcome in order to optimize treatments in this population."

The researchers found that gene transfer by adenovirus is less efficient in aging rat heart cells than in cells from their younger counterparts. Over the years, adenoviruses have been used in laboratory and clinical research to deliver beneficial genes into their target cells. These modified viruses rely on several proteins on the surface of cells in order to gain entry and deliver therapeutic genes.

Hajjar's group had previously shown that aging cells are more resistant to entry by adenovirus than adult cells, but it had not been clear why. Through detailed laboratory experiments, the research team found that crucial proteins called integrins, which sit just under a cell's membrane, are scarce in older cardiac cells. It turns out that adenoviruses need these integrins to get into cells.

"The adenovirus binds to a receptor on the outside of a cell that is linked to integrins below the cell's surface," says Hajjar, who is an associate professor of Medicine at Harvard Medical School. "The receptor itself is abundant in older cells, but the integrins are deficient."

This may sound like bad news for the elderly, but Hajjar points out that it is possible to boost the expression of integrins. "The next step is to devise different ways of stimulating integrins specifically so you can still u
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
3-Mar-2003


Page: 1 2

Related biology news :

1. Hemophilia therapy update: New information on investigational Factor VIII therapy development
2. Factor for acquiring skin barrier function identified
3. Enzyme Presence Could Be Key Factor In Wolf Health, Study Suggests
4. UCSF Scientists Report On A Transcription Factor That Could Stimulate Heart Cells To Repair Damage Caused By Heart Attacks Or Birth Defects
5. Genetic, Familial Factors Influence ADHD, Not Necessarily Sex Of Child
6. Allelix Clones Receptor For Intestinal Growth Factor GLP-2
7. Gene Influences Heart Disease And Stroke Risk Factors
8. Growth Factors Improve Muscle Healing In Animals
9. Growth Factor Contributes To Angiogenesis
10. One Way Traffic: Max Planck Scientists Idendified Genes Involved In Transporting An Important Plant Growth Factor
11. Environmental Factors Contribute To High Blood Pressure In African-American Males

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/14/2019)... ... 2019 , ... Join the live session on ... topics in data quality, including:, ,     State of the art ...     Smartphone and wearable based performance measures ,     Data quality analytics ...
(Date:1/8/2019)... ... January 07, 2019 , ... Join industry experts Julie Peacock, Client ... live webinar on Thursday, January 17, 2019 at 1pm EST. , This ... during the clinical trial process. Featured speakers will also present a case study of ...
(Date:1/7/2019)... ... January 07, 2019 , ... Franz Inc. ... Database technology for Knowledge Graphs solutions, announced that it was recognized by ... DBTA’s data and information management recognition list includes newer approaches leveraging artificial ...
Breaking Biology News(10 mins):
(Date:1/4/2019)... ... January 01, 2019 , ... uBiome, the leader in microbial ... Annual Meeting January 22-25, 2019 held in Davos-Klosters, Switzerland following their selection as ... Annual Meeting brings together leaders of global society–the heads and members of more ...
(Date:12/20/2018)... ... 20, 2018 , ... New Year’s brings reflection and desire to improve for ... European Union (EU) on the horizon, Jim Kasic, president and CEO of Boulder iQ, ... EU Medical Device Regulation (MDR), digital health, and big data are just a few ...
(Date:12/18/2018)... Conn. (PRWEB) , ... December 17, 2018 , ... ... announced today the second cohort of emerging biosciences ventures invited to participate in ... business education to develop fundable business plans and a professional network. All startups ...
(Date:12/14/2018)... ... 2018 , ... NOVA OCULUS PARTNERS, LLC, and its Canadian ... immediately begin a clinical patient trial in Edmonton using their pioneering technology for ... has granted what is called an Investigational Testing Authorization for the trial, while ...
Breaking Biology Technology:
Cached News: