turned "on" and "off." DNA damage was linked to the protein ATR and measured using comet assays.
"If blocking DNA repair proves to be the cause of blast crisis, then we may be able to prevent CML from progressing to its final stage by interrupting the action of cancer gene BCR/ABL," said Carroll. "Ultimately, this could lead to a long-term treatment for the disease that may also be applied to other progressive cancers."
Funding for the study was provided through grants from Penn's School of Medicine and the National Cancer Institute (NCI). Started in January 1999, the study will continue through 2004 to determine the causal nature, if any, between BCR/ABL and blast crisis.
CML is a fatal blood cancer that primarily affects people over age 40. There are approximately 5,000 new cases each year in the United States, and nearly 2,000 people die from the disease. During the first stage of the illness, people live for three to five years after diagnosis. On average, people live for only three months to one year after entering the final, second stage of the disease.
Page: 1 2 Related biology news :1
Contact: David March
University of Pennsylvania School of Medicine
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