HOME >> BIOLOGY >> NEWS
False Security: You Can't Always Believe The Results Of A Genetic Test

Many laboratories offering genetic tests for cystic fibrosis don't test for enough mutations to give reliable results, according to a new study.

Last year, a panel convened by the US National Institutes of Health (NIH) recommended that prospective parents be routinely offered tests to see if they carry mutations that could give their children cystic fibrosis. This was the first time a genetic test had been recommended for the general population (This Week, 26 April 1997, p 12). The new findings, from a team of geneticists led by Wayne Grody of the University of California at Los Angeles, suggest that this recommendation was premature.

Cystic fibrosis, in which the lungs and airways become clogged with mucus and prone to infections, is caused by defects in a single large gene. There are hundreds of these mutations. Some are very rare, and certain mutations are more common in particular ethnic groups.

To be effective, the widespread screening urged by the NIH panel would have to test for many of the most common mutations. Exactly how many is still a matter of debate. "One thing that was conspicuously lacking from the panel's recommendation was how many mutations should be tested for," says Grody, who is co-chair of a committee drawing up guidelines on the issue for the American College of Medical Genetics (ACMG). To identify 90 per cent or more of people carrying cystic fibrosis genes, it may be necessary to test for 20 of the most common mutations, Grody predicts.

Grody also leads a team of geneticists monitoring the testing labs on behalf of the ACMG and the College of American Pathologists. The team's latest survey, published in The American Journal of Human Genetics (vol 62, p 1252), reveals a disturbing picture. The investigators asked 45 labs how many mutations in the cystic fibrosis gene they usually test for. Forty-three responded, reporting numbers ranging from just one to 70. It was most co
'"/>

Contact: Claire Bowles
Claire Bowles@rbi.co.uk
01 71 331-2751
New Scientist
20-May-1998


Page: 1 2

Related biology news :

1. Cant stand the pain? Your genes may be to blame
2. If You Cant Stop Polluting, Try Changing The Weather Instead
3. As A Carbon Sponge, Iron-Poor Coastal Waters Cant Always Do The Job, NaturePaper Shows
4. The Commons: Not Always A Tragedy
5. Once A Bully, Always A Bully, Invasive Non-Native Plants Tend To Be Aggressive Wherever They Find Themselves
6. Chemical Reaction Believed To Support Underground Microbes Is Now Unlikely
7. Results of pivotal study for GlaxoSmithKlines Valtrex published in New England Journal of Medicine
8. Results from open-label Raptiva study suggest continued benefit with long-term treatment
9. NASA Materials Conference Features Science Results, Experts on Technologies for Exploration
10. Abgenix Reports Encouraging Preclinical Results With ABX-EGF In Cancer Research
11. Encouraging Results In Preclinical Studies Of Parkinsons Disease Gene Therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/8/2019)... (PRWEB) , ... January 07, 2019 , ... ... and compliance solutions, is proud to welcome Thomas Kennedy as head of sales ... Miglicco, CEO for PureWay. , Mr. Kennedy has previously worked for Johnson & ...
(Date:1/7/2019)... ... January 07, 2019 , ... Franz Inc. , ... technology for Knowledge Graphs solutions, announced that it was recognized by Database ... DBTA’s data and information management recognition list includes newer approaches leveraging artificial intelligence, ...
(Date:1/4/2019)... (PRWEB) , ... January 03, 2019 , ... ... adopt 3D cell culture models into their drug discovery research workflows with biology ... improve the in vivo relevancy of in vitro studies, they create several challenges ...
Breaking Biology News(10 mins):
(Date:12/20/2018)... Colo. (PRWEB) , ... December 20, 2018 , ... New ... 2019, with major changes in regulations in the European Union (EU) on the horizon, ... companies to consider. , “The transition to the EU Medical Device Regulation (MDR), digital ...
(Date:12/19/2018)... ... December 19, 2018 , ... ... the validated release of Limfinity® version 7.1. The new release enhances the latest ... RURO as 2018 comes to an end. , Validation protocols, and their execution, ...
(Date:12/18/2018)... ... December 18, 2018 , ... USDM ... for the life sciences industry, unveiled a completely redesigned website at http://www.usdm.com ... user-friendly browsing experience for their valued clients and business partners. , The ...
(Date:12/14/2018)... ... December 14, 2018 , ... NOVA OCULUS PARTNERS, LLC, ... green light to immediately begin a clinical patient trial in Edmonton using their ... of Health Canada has granted what is called an Investigational Testing Authorization for ...
Breaking Biology Technology:
Cached News: