HOME >> BIOLOGY >> NEWS
Families with severe form of bipolar disorder help scientists narrow the search for disease genes

After years of frustrating searches for genes that contribute to mental illness, researchers at Johns Hopkins studying families with a severe form of manic depressive illness, called psychotic bipolar disorder, may be one step closer to finding the genetic underpinnings of both bipolar disorder and schizophrenia.

"Finding a gene for bipolar disorder is like finding a needle in a haystack, but by focusing our search on families with a distinctive form of the illness we were able to pinpoint a region of the genome where disease genes are likely to be found," said James Potash, M.D., assistant professor of psychiatry at Johns Hopkins and lead author of a report on the study in the April issue of the American Journal of Psychiatry.

Although genes are unlikely to tell the whole story of major psychiatric diseases, the persistent frequency of mental illness in about 1 percent of the global human population, regardless of cultural or ethnic differences, and its tendency to run in families have always pointed to a strong genetic role. "But pinning down that role is complicated by the many variations in symptoms, even within the same family," says Potash. "There are probably many different genes and environmental factors that can cause any given mental illness."

Motivated by previous suggestions that certain broad regions of the DNA sequence, especially on human chromosomes 13 and 22, may contain genes that contribute to both bipolar disorder and schizophrenia, Potash and colleagues focused on those families with the psychotic form of bipolar disorder. Like bipolar disorder, psychotic bipolar disorder is characterized by see-sawing episodes of depression and mania, but it is distinctive because these mood changes often are accompanied by such psychotic symptoms as hallucinations and delusions.

The concept for the new study is that of two slightly overlapping circles, explains Potash. In one circle are all of the genes that con
'"/>

Contact: Trent Stockton
tstockt1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
1-Apr-2003


Page: 1 2

Related biology news :

1. Families with two or more children with autism sought for $10.2 million study
2. Sudden Cardiac Death May Run In Families
3. Vastly Different Virus Families May Be Related
4. New Medication Means New Choices For Families Dealing With Alzheimers Disease
5. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
6. Screen siblings, parents of infants with severe heart abnormalities
7. Memory fails you after severe stress
8. Animal studies show promise treating severe chronic pain
9. Immunity gene predicts severe adverse drug reaction
10. People with undetermined muscle/bone pain tend to be severely vitamin D deficient
11. Early treatment can prevent severe vision loss in premature infants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2018)... ... , ... With increasing safety requirements, and time and financial pressure, the development ... To be successful in such a competitive environment, it is more important than ever ... needed to develop a new drug or to execute fundamental research. , In ...
(Date:8/15/2018)... ... August 15, 2018 , ... The Florida Chiropractic Association’s National Meeting ... Doctors from around the U.S. will gain firsthand insights into the new laser’s ... completed another successful clinical trial that has resulted in the granting of an ...
(Date:8/14/2018)... ... August 13, 2018 , ... Castle Dental® has partnered ... office on South Lamar Blvd. to provide free dental services for underinsured, low-income ... include x-rays and exams, fillings , extractions , cleanings ...
Breaking Biology News(10 mins):
(Date:7/31/2018)... , ... July 31, 2018 , ... ... for 65 years, announces the launch of their new website. The new website ... experience throughout the site. Mahoney partnered with Proceed Innovative to build a website ...
(Date:7/25/2018)... ... July 25, 2018 , ... ... energy treated proprietary nutraceutical to combat inflammation and autoimmune disorders. , The ... function response. The following data was reported:, Over ...
(Date:7/25/2018)... ... July 25, 2018 , ... John McDonald, CEO ... board of the Indiana India Business Council (IIBC), an advocacy group to strengthen ... current board of directors, McDonald joins an impressive roster of local and national ...
(Date:7/24/2018)... ... July 24, 2018 , ... On August 6, ... SmartTRAK platform. Not just a pretty face, SmartTRAK 3.0’s latest improvements were ... SmartTRAK is the world’s first online and real-time data portal that specializes in ...
Breaking Biology Technology:
Cached News: