HOME >> BIOLOGY >> NEWS
Family history doesnt predict colon cancer genes, behavior

Although certain genes and some behaviors, like eating well-done red meat, are associated with a family history of colon cancer, that history is not a good tool for predicting whether an individual will have a colon cancer-related gene or engage in a high-risk behavior, according to new research.

"The predictive value of family history for identifying persons with at-risk genotypes or environmental risk factors is low," say Temitope O. Keku, Ph.D., of the University of North Carolina at Chapel Hill and colleagues.

However, the researchers also found that people with a family history of colon cancer were as likely as people without a family history to have high-risk diets that included lots of cooked red meat and low amounts of folate, a vitamin that may help prevent colon cancer.

"Modification of these factors could have broad benefits and interventions could be targeted to persons with a family history regardless of their genes," Keku says.

Keku and colleagues analyzed the DNA of 230 black and white adults with a family history of colon cancer, looking for cancer-related variations in four different genes. The researchers also collected information on the study participants' eating habits and their use of nonsteroidal anti-inflammatory drugs like aspirin or ibuprofen, which seem to have a protective effect against colon cancer.

The prevalence of cancer-related variations of a gene called NAT2 was significantly higher among individuals with a family history of colon cancer. Individuals with the NAT2 variant who also reported regular red meat consumption were also more likely to have a family history of colon cancer.

The researchers also found that participants with a family history had a higher prevalence of cancer-related variants of the PPARG gene in combination with low levels of aspirin use.

Despite these findings, family history is a poor predictor of whether an individual has a colon cancer-related gene
'"/>

Contact: Temitope Keku, Ph.D.
tokeku@med.unc.edu
919-966-5828
Center for the Advancement of Health
10-Feb-2003


Page: 1 2

Related biology news :

1. Family-friendly, flexible and far-reaching
2. Family communication about hereditary disease vital to prevention
3. Family connections feed eating disorders research
4. UCSF Research Team Looking For Volunteers For Nationwide Study On Family Traits And Alcoholism
5. A Missing Link Fossil Adds Foliage To The Early Human Ancestor Family Tree
6. New Form Of Inherited Dwarfism In Large Pakistani Family Caused By Genetic Mutation In A Pituitary Receptor
7. Tau Gene Linked To Family Of Neurodegenerative Disorders; Finding May Yield Insight Into Onset Of Alzheimers Disease
8. NIEHS And U.C. Davis Researchers Find Protein That May Be Key To Non-Hormonal Family Planning And Treatment Of Infertility
9. Family Members And Kissing Contacts At Greater Risk Of Meningitis
10. Researchers Discover Novel Gene Family Responsible For Pacemaker Activity In Brain And Heart
11. Family Ties To Sudden Cardiac Arrest; Study Finds Risk Goes Up 50 Percent

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Family history doesnt predict colon cancer genes behavior

(Date:12/17/2014)... , Dec. 16, 2014 Valencell, a leader ... PerformTek biometric technology to industry leaders such as Intel, ... clinically validated, biometric wearable products. These products will be ... Las Vegas . ... accurate, flexible and robust – with the clinical data ...
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the ... 2015-2019" report to their offering. ... is the adoption of multimodal biometric systems. Multimodal ... an individual for verification and identification purposes. This ...
(Date:12/10/2014)... WINSTON-SALEM, N.C. , Dec. 9, 2014  Wake Forest ... medical education building for its School of Medicine. Funding ... a larger capital campaign that will be publicly launched ... will be located in the former 60 series R.J. ... Forest Innovation Quarter. Construction will begin immediately with plans ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
(Date:12/19/2014)... December 18, 2014 With only 2 ... special on Sartorius Biohit products . The product ... pipettes, Picus Electronic Pipette Trade-in Program, and free pipette ... Safety officers around the world. They are ideal for ... features include:, ,     Full volume range of ...
(Date:12/19/2014)... Egenix, Inc. is pleased to announce that Lionel Goldfrank ... succeed Donald Fresne ; Mr. Fresne has also resigned ... of the Board.  In recognition of the many contributions and ... twenty years, the Board designated Mr. Fresne as Chairman Emeritus. ... Search Committee to find a suitable replacement with Biotech industry ...
(Date:12/19/2014)... -- Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage company ... announced the results of its annual general meeting of ... year in Relmada,s history and it set the stage ... Sergio Traversa , chief executive officer of Relmada. "Over ... human resource and clinical development objectives that position Relmada ...
(Date:12/17/2014)... December 17, 2014 Based on ... overall surgical imaging market is dominated by four ... surgical imaging market. These players include GE Healthcare ... Imaging (Germany). , Full Report Copy at ... GE Healthcare can be attributed to its strong ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4
Cached News: