HOME >> BIOLOGY >> NEWS
Family history doesnt predict colon cancer genes, behavior

Although certain genes and some behaviors, like eating well-done red meat, are associated with a family history of colon cancer, that history is not a good tool for predicting whether an individual will have a colon cancer-related gene or engage in a high-risk behavior, according to new research.

"The predictive value of family history for identifying persons with at-risk genotypes or environmental risk factors is low," say Temitope O. Keku, Ph.D., of the University of North Carolina at Chapel Hill and colleagues.

However, the researchers also found that people with a family history of colon cancer were as likely as people without a family history to have high-risk diets that included lots of cooked red meat and low amounts of folate, a vitamin that may help prevent colon cancer.

"Modification of these factors could have broad benefits and interventions could be targeted to persons with a family history regardless of their genes," Keku says.

Keku and colleagues analyzed the DNA of 230 black and white adults with a family history of colon cancer, looking for cancer-related variations in four different genes. The researchers also collected information on the study participants' eating habits and their use of nonsteroidal anti-inflammatory drugs like aspirin or ibuprofen, which seem to have a protective effect against colon cancer.

The prevalence of cancer-related variations of a gene called NAT2 was significantly higher among individuals with a family history of colon cancer. Individuals with the NAT2 variant who also reported regular red meat consumption were also more likely to have a family history of colon cancer.

The researchers also found that participants with a family history had a higher prevalence of cancer-related variants of the PPARG gene in combination with low levels of aspirin use.

Despite these findings, family history is a poor predictor of whether an individual has a colon cancer-related gene
'"/>

Contact: Temitope Keku, Ph.D.
tokeku@med.unc.edu
919-966-5828
Center for the Advancement of Health
10-Feb-2003


Page: 1 2

Related biology news :

1. Family-friendly, flexible and far-reaching
2. Family communication about hereditary disease vital to prevention
3. Family connections feed eating disorders research
4. UCSF Research Team Looking For Volunteers For Nationwide Study On Family Traits And Alcoholism
5. A Missing Link Fossil Adds Foliage To The Early Human Ancestor Family Tree
6. New Form Of Inherited Dwarfism In Large Pakistani Family Caused By Genetic Mutation In A Pituitary Receptor
7. Tau Gene Linked To Family Of Neurodegenerative Disorders; Finding May Yield Insight Into Onset Of Alzheimers Disease
8. NIEHS And U.C. Davis Researchers Find Protein That May Be Key To Non-Hormonal Family Planning And Treatment Of Infertility
9. Family Members And Kissing Contacts At Greater Risk Of Meningitis
10. Researchers Discover Novel Gene Family Responsible For Pacemaker Activity In Brain And Heart
11. Family Ties To Sudden Cardiac Arrest; Study Finds Risk Goes Up 50 Percent

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Family history doesnt predict colon cancer genes behavior

(Date:11/21/2014)... Nov. 20, 2014   Atmel® Corporation (NASDAQ: ... (MCU) and touch technology solutions, today launched the industry,s ... with the widest V cc range from 1.7V ... and faster I 2 C bus communication speeds, and ... memory making them ideal for consumer, industrial, computer, and ...
(Date:11/18/2014)...   EyeLock Inc. , a market leader ... USA (Safran), a leading U.S. provider of ... partnership to offer comprehensive biometric identity solutions and ... screening and financial services markets. As ... through a nationwide network of 1,100 IdentoGO® Centers.  ...
(Date:11/10/2014)... U.S. store shelves in early 2010, and people have ... packets can be tossed into a washing machine without ... The convenience, though, has come with risks for young ... Children,s Hospital found that from 2012 through 2013, U.S. ... than 6 years of age swallowing, inhaling, or otherwise ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Study finds laundry detergent pods, serious poisoning risk for children 2
(Date:11/26/2014)... MINNEAPOLIS , Nov. 25, 2014 Bio-Techne ... it has appointed Robert Gavin to serve ... of the Protein Platforms Division.  Mr. Gavin will be ... business segment, which includes the ProteinSimple business acquired in ... San Jose, California -based ProteinSimple ...
(Date:11/26/2014)... WARREN, N.J. , Nov. 25, 2014  Roka Bioscience, ... focused on providing advanced testing solutions for the detection of ... will present at the Piper Jaffray  26 th Annual ... conference will be held at The New York Palace in ... During this presentation, material information concerning the Company, its operations, ...
(Date:11/24/2014)... UAE, November 24, 2014 Five ... Bin Rashid Al Maktoum Awards for Medical Sciences", in ... Dubai, United Arab Emirates , on 15 December ... , The Carter Center which won the ... actively involved in numerous programs that aim to improve ...
(Date:11/24/2014)... Belgium , Nov. 24, 2014 ... on developing diagnostic tests for cancer and other conditions, today ... be presented at the Science for Business BioWin Day 2014, ... . The data come from VolitionRx,s lung cancer pilot ... department of the Centre Hospitalier Universitaire (CHU) de Liege in ...
Breaking Biology Technology:Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 3Roka Bioscience to Present at the Piper Jaffray Healthcare Conference 2Five US Winners Among Recipients of Hamdan Medical Awards 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6
Cached News: