HOME >> BIOLOGY >> NEWS
Family history doesnt predict colon cancer genes, behavior

Although certain genes and some behaviors, like eating well-done red meat, are associated with a family history of colon cancer, that history is not a good tool for predicting whether an individual will have a colon cancer-related gene or engage in a high-risk behavior, according to new research.

"The predictive value of family history for identifying persons with at-risk genotypes or environmental risk factors is low," say Temitope O. Keku, Ph.D., of the University of North Carolina at Chapel Hill and colleagues.

However, the researchers also found that people with a family history of colon cancer were as likely as people without a family history to have high-risk diets that included lots of cooked red meat and low amounts of folate, a vitamin that may help prevent colon cancer.

"Modification of these factors could have broad benefits and interventions could be targeted to persons with a family history regardless of their genes," Keku says.

Keku and colleagues analyzed the DNA of 230 black and white adults with a family history of colon cancer, looking for cancer-related variations in four different genes. The researchers also collected information on the study participants' eating habits and their use of nonsteroidal anti-inflammatory drugs like aspirin or ibuprofen, which seem to have a protective effect against colon cancer.

The prevalence of cancer-related variations of a gene called NAT2 was significantly higher among individuals with a family history of colon cancer. Individuals with the NAT2 variant who also reported regular red meat consumption were also more likely to have a family history of colon cancer.

The researchers also found that participants with a family history had a higher prevalence of cancer-related variants of the PPARG gene in combination with low levels of aspirin use.

Despite these findings, family history is a poor predictor of whether an individual has a colon cancer-related gene
'"/>

Contact: Temitope Keku, Ph.D.
tokeku@med.unc.edu
919-966-5828
Center for the Advancement of Health
10-Feb-2003


Page: 1 2

Related biology news :

1. Family-friendly, flexible and far-reaching
2. Family communication about hereditary disease vital to prevention
3. Family connections feed eating disorders research
4. UCSF Research Team Looking For Volunteers For Nationwide Study On Family Traits And Alcoholism
5. A Missing Link Fossil Adds Foliage To The Early Human Ancestor Family Tree
6. New Form Of Inherited Dwarfism In Large Pakistani Family Caused By Genetic Mutation In A Pituitary Receptor
7. Tau Gene Linked To Family Of Neurodegenerative Disorders; Finding May Yield Insight Into Onset Of Alzheimers Disease
8. NIEHS And U.C. Davis Researchers Find Protein That May Be Key To Non-Hormonal Family Planning And Treatment Of Infertility
9. Family Members And Kissing Contacts At Greater Risk Of Meningitis
10. Researchers Discover Novel Gene Family Responsible For Pacemaker Activity In Brain And Heart
11. Family Ties To Sudden Cardiac Arrest; Study Finds Risk Goes Up 50 Percent

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/31/2017)... , Jan. 31, 2017  Spero Therapeutics, LLC, ... for the treatment of bacterial infections, today announced ... antibacterial candidates from Pro Bono Bio Ltd (PBB) ... of multi-drug resistant forms of Gram-negative bacteria.   The ... Infectives Ltd, a PBB group company. ...
(Date:1/26/2017)... Jan. 26, 2017  Acuity Market Intelligence today ... and Digital Identity".  Acuity characterizes 2017 as a ... increased adoption reflects a new understanding of the ... "Biometrics and digital identity are often perceived as ... Most , Principal of Acuity Market intelligence. "However, ...
(Date:1/24/2017)... 2017  It sounds simple and harmless—an electronic ... vital signs and alerts parents on their smart ... level drops. But pediatric experts argue that such ... no evidence of medical benefits, especially to healthy ... to parents of healthy babies, promising peace of ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... 21, 2017   Invitae Corporation (NYSE: NVTA), ... announced that members of the company,s management team will ... Care Conference on Monday, March 6, 2017 at approximately ... Boston, Massachusetts . The ... by visiting the investors section of the company,s website ...
(Date:2/20/2017)... ... February 20, 2017 , ... Global relationship marketing ... approved for full, active membership in the Canadian Direct Sellers Association (DSA) effective ... Executive Officer Jeff Olson in 2011. Today Nerium International, with its ...
(Date:2/20/2017)... Report analyzes the worldwide markets for Bioinformatics in US$ by the ... analytics for the US, Canada , ... , Latin America , and Rest of ... ... and forecasts are provided for the period 2015 through 2022. Also, ...
(Date:2/20/2017)... ... February 20, 2017 , ... ... solutions for the food and pharmaceutical processing and packaging industries, was runner-up for ... manufacturer that has done the most or taken the most innovative steps to ...
Breaking Biology Technology:
Cached News: