HOME >> BIOLOGY >> NEWS
Family history doesnt predict colon cancer genes, behavior

Although certain genes and some behaviors, like eating well-done red meat, are associated with a family history of colon cancer, that history is not a good tool for predicting whether an individual will have a colon cancer-related gene or engage in a high-risk behavior, according to new research.

"The predictive value of family history for identifying persons with at-risk genotypes or environmental risk factors is low," say Temitope O. Keku, Ph.D., of the University of North Carolina at Chapel Hill and colleagues.

However, the researchers also found that people with a family history of colon cancer were as likely as people without a family history to have high-risk diets that included lots of cooked red meat and low amounts of folate, a vitamin that may help prevent colon cancer.

"Modification of these factors could have broad benefits and interventions could be targeted to persons with a family history regardless of their genes," Keku says.

Keku and colleagues analyzed the DNA of 230 black and white adults with a family history of colon cancer, looking for cancer-related variations in four different genes. The researchers also collected information on the study participants' eating habits and their use of nonsteroidal anti-inflammatory drugs like aspirin or ibuprofen, which seem to have a protective effect against colon cancer.

The prevalence of cancer-related variations of a gene called NAT2 was significantly higher among individuals with a family history of colon cancer. Individuals with the NAT2 variant who also reported regular red meat consumption were also more likely to have a family history of colon cancer.

The researchers also found that participants with a family history had a higher prevalence of cancer-related variants of the PPARG gene in combination with low levels of aspirin use.

Despite these findings, family history is a poor predictor of whether an individual has a colon cancer-related gene
'"/>

Contact: Temitope Keku, Ph.D.
tokeku@med.unc.edu
919-966-5828
Center for the Advancement of Health
10-Feb-2003


Page: 1 2

Related biology news :

1. Family-friendly, flexible and far-reaching
2. Family communication about hereditary disease vital to prevention
3. Family connections feed eating disorders research
4. UCSF Research Team Looking For Volunteers For Nationwide Study On Family Traits And Alcoholism
5. A Missing Link Fossil Adds Foliage To The Early Human Ancestor Family Tree
6. New Form Of Inherited Dwarfism In Large Pakistani Family Caused By Genetic Mutation In A Pituitary Receptor
7. Tau Gene Linked To Family Of Neurodegenerative Disorders; Finding May Yield Insight Into Onset Of Alzheimers Disease
8. NIEHS And U.C. Davis Researchers Find Protein That May Be Key To Non-Hormonal Family Planning And Treatment Of Infertility
9. Family Members And Kissing Contacts At Greater Risk Of Meningitis
10. Researchers Discover Novel Gene Family Responsible For Pacemaker Activity In Brain And Heart
11. Family Ties To Sudden Cardiac Arrest; Study Finds Risk Goes Up 50 Percent

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Family history doesnt predict colon cancer genes behavior

(Date:10/15/2014)... of Life, is a non-traditional biophysics textbook and it ... is a journey of discovery into biological systems and ... biological regulation. It is about how our genes make ... the billions of cells in an organism. It quantifies ... principles, which can be found on both large and ...
(Date:10/15/2014)... Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market releases photos and video ... Square on Monday October 13 th . ... Tunnel and angel investor Mr. Chad A. Verdi ... of NXT-ID thanked his investors and employees "for their work and ...
(Date:10/14/2014)... Cancer Research shows SIRT6—a protein known to ... the development of skin cancers by turning on an ... skin cells. , Previously considered protective, SIRT6 is part ... help regulate genomic stability and prevent some of the ... damage, which can lead to cancer. This study, in ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
(Date:10/22/2014)... 22, 2014 Physicians Choice Laboratory ... pharmacogenetics menu, which enables healthcare providers to individualize ... PCLS’s evidence-based results, healthcare providers are better able ... therapy, while minimizing risks for adverse drug reactions ... to the FDA [1] more than 2.2 million ...
(Date:10/22/2014)... 2014 Research and Markets  has announced ... Material, by Application, Geography - Global Analysis and Forecast ... Organic electronics, also called as polymer electronics ... which deals with small conductive molecules and electrically conductive ... and polymers are carbon based, made using synthetic strategies ...
(Date:10/20/2014)... , Oct. 20, 2014 Asterias ... the Company has signed a Notice of Grant ... Medicine (CIRM), effective October 1, 2014.  The NGA ... payments and the release of additional grant funds ... grant award for clinical development of Asterias, product, ...
(Date:10/20/2014)... N.J. (PRWEB) October 20, 2014 ... the Sidney Kimmel Cancer Center at Thomas Jefferson ... , Through the Strategic Alliance Partnership program, ... OncLive will collaborate to raise awareness of the ... treatment, and other projects. Clinicians and other health ...
Breaking Biology Technology:PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3
Cached News: