HOME >> BIOLOGY >> NEWS
Fas signaling and cardiac hypertrophy

Stimulation of Fas, the founding member of a family of dedicated cell surface "death receptors," activates one of the best studied routes to apoptosis. Evidence for Fas activation in cardiac myocytes subjected to pressure overload is therefore not surprising, but Badorff et al. have found that this protein subserves an unexpected role in these cells. As has been noted before, cardiac overexpression of the Fas ligand (FasL) does not kill myocytes but rather leads to a metabolic and morphological transition reminiscent of the adaptive hypertrophy. Working with cultured neonatal myocytes, Badorff and colleagues show that FasL treatment activates Akt, a protein kinase that has been extensively implicated in the hypertrophic response in the heart and elsewhere. Hypothesizing that Fas participates in the adaptive hypertrophy that allows the heart to compensate for pressure overload, the authors tested the effects of aortic banding in lpr mice, which are deficient in Fas. As predicted, these mice failed to compensate and often died within a week of the operation. Interestingly, mice lacking FasL showed no such defect, indicating that, although FasL can induce this response, Fas can be activated by other means during adaptive hypertrophy.


'"/>

Contact: John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
30-Jan-2002


Page: 1

Related biology news :

1. Activated signaling pathway may predict lung cancer patients response to gefitinib
2. NRH1 and Wnt signaling come together in convergent extension
3. From lung to gut the Wnt signaling pathway transforms cell fate
4. Equine clonings triple play sheds light on calcium, cell signaling, human disease
5. UT Southwestern researchers learn importance of insulin family signaling in male sex determination
6. Mantis shrimp fluoresce to enhance signaling in the dim ocean depths
7. OHSU researchers discover molecular signaling system controlling aspects of embryonic development
8. New study identifies gene signaling puberty
9. Are the bright colors of some avian eggs signaling female genetic quality to their mates?
10. Scientists map signaling molecule crucial to survival, disease
11. Researchers identify molecular signaling system that is crucial for plant fertility

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2019)... , ... June 14, 2019 , ... ... invited to lecture at the fifth annual Neodent World Congress. Attended by thousands ... innovative progress and latest advancements in the world of dentistry. The three-day event ...
(Date:6/11/2019)... , ... June 12, 2019 , ... ... antibody discovery services, Abveris plans to leverage the Geneious Biologics platform as a ... Souders, Chief Technology Officer at Abveris, says: “The Geneious team has done an ...
(Date:6/4/2019)... ... June 04, 2019 , ... In’Tech Medical SAS ( ... Q1-19 revenues of $31M, up 12% from Q1-18. The growth is associated with ... & operational excellence initiatives worldwide. , Laurent Pruvost , President & CEO ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 11, 2019 , ... ... Stem Cells Inc. (PSC) , has announced that their GMP facility for cell ... Drug Branch for manufacturing. This is an important milestone for VetStem as ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... applications from the USPTO providing proprietary interest to our methodology, processes, and ... DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including our proprietary sleep ...
(Date:5/22/2019)... ... May 22, 2019 , ... Artemis (formerly Agrilyst), the ... Series A funding round co-led by Astanor Ventures and Talis Capital ... and iSelect Fund . The company has raised $11.75m to date and ...
(Date:5/14/2019)... ... May 13, 2019 , ... Leak Detection Associates ... the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is excited to announce ... to improve LDA’s ability to communicate directly with the marketplace; serving as a ...
Breaking Biology Technology:
Cached News: