HOME >> BIOLOGY >> NEWS
Fat cell hormone causes weight loss

Penn(Philadelphia, PA) - Researchers at the University of Pennsylvania School of Medicine have established in an animal model that the hormone adiponectin secreted by fat tissue acts in the brain to reduce body weight. In contrast to leptin, a related hormone, adiponectin can cause weight loss by raising metabolic rate while not affecting appetite. This finding may have future implications in understanding and treating obesity and metabolic disorders like diabetes, says lead author, Rexford Ahima, MD, PhD, Assistant Professor of Medicine, Penn Diabetes Center. This research appears in the May issue of Nature Medicine.

When adiponectin, which is involved in glucose and lipid metabolism, was introduced into the cerebrospinal fluid of normal mice, they showed no changes in food intake, but their metabolism rose. "The animal burns off more calories, so over time loses weight, which was very fascinating because we knew that leptin caused weight loss by suppressing appetite and increasing metabolic rate," explains Ahima. "Here we have another fat hormone that can cause weight loss but without affecting intake."

For many dieters, it's easy, at first, to lose weight; but over time, it becomes more difficult because the body compensates, in part, by dropping its metabolic rate. "Adiponectin or its targets in the brain and other organs could be harnessed to sustain weight loss by maintaining a high metabolic rate," says Ahima. "This is only a possibility. We're not suggesting at this point that adiponectin will become a drug." In severely obese mice, adiponectin rapidly decreases blood glucose and lipids, while burning fat. Hence, adiponectin could be beneficial in the treatment of diabetes and heart disease associated with obesity.

These findings have far-reaching potential to help fight the war against obesity, which healthcare experts agree has reached epidemic proportions in the United States. "For y
'"/>

Contact: Karen Kreeger
Karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
22-Apr-2004


Page: 1 2

Related biology news :

1. Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
2. Excess thyroid hormone harmful to fetus
3. Blood pressure hormone may inhibit growth of lung cancer
4. Hunt for a new plant hormone points to carotenoids
5. When male fish hum, females swim in, thanks to hormones, adaptable hearing
6. Evidence for fat hormone target in brain
7. Synthetic hormone used in contraceptives and HRT produces negative effects in monkey studies
8. Moderate alcohol consumption increases plasma levels of a protective hormone
9. OHSU researchers discover possible connection between infant hormone exposure, obesity
10. Fat hormone leptin alters brain architecture and activity, which in turn drives feeding behavior
11. Stress hormones and heart failure

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/4/2020)... ... July 03, 2020 , ... Aesthetics Biomedical ... and multiple awards for not only the products and treatments developed, but also ... Vivace® Microneedle RF. All the brands built by ABM have received several honors ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... biopharmaceutical R&D, today announced that it has entered into a multi-year contract ... (Multiclonics®), to support their translational and clinical research strategy to discover and ...
(Date:6/23/2020)... (PRWEB) , ... June 22, 2020 , ... The field ... Typically, ligand binding assays (LBA) have dominated this area. However, the use of mass ... years. , This now necessitates the question “How do you choose which approach to ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and ... a great surgery is only the beginning of a successful study, while protecting and ... Join Brad Gien, Global Head of Surgery from Envigo in a ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, a ... laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume ... Bode-CARES provides a turnkey solution that includes a comprehensive collection and virus-management ...
(Date:7/7/2020)... ... 06, 2020 , ... R3 International is now offering stem cell therapy for ... cells. Depending on the patient's condition, treatment may be offered IV, intrathecal or with ... form of Alzheimers dementia, and the incidence continues to increase as individuals live longer. ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... today announced that the launch of a new clinical diagnostics immuno-oncology ... the tumor microenvironment (TME). , “Flagship’s TissueInsight is a service that aids ...
Breaking Biology Technology:
Cached News: