HOME >> BIOLOGY >> NEWS
Fat cells fight disease, Purdue University researchers find

WEST LAFAYETTE, Ind. - Fat cells, commonly blamed for a number of diseases, also may aid in the body's defense against illnesses such as diabetes and cancer, according to Purdue University researchers.

Rather than contributing to disease, fat cells, or adipocytes (pronounced ah-dip-poe-sights), normally function as part of the immune system and help control lipid accumulation, so they actually may benefit human health, said Michael Spurlock, animal sciences professor.

"Adipocytes can be functional and beneficial without creating obesity," Spurlock said. "The key is that we want plenty of adipocytes to meet whatever immunological and endocrinological needs they fulfill, but we don't want them to overaccumulate lipid."

In the January issue of The American Journal of Physiology, Spurlock and Kolapo Ajuwon, both of the Department of Animal Sciences and the Comparative Medicine Program, report that pig fat cells respond to infections by producing hormone-like proteins that regulate certain aspects of the body's immune response.

"This is additional evidence that fat cells behave in many ways as immune cells," Spurlock said. "It also is the first evidence that adipocyte cells respond directly to bacterial toxins like classical immune cells."

To produce this infection-fighting response, Ajuwon, a doctoral student, performed experiments exposing fat cells to interferon-gamma, a small protein produced by infection-fighting T-cells. This caused the adipocytes to produce hormone-like proteins, called cytokines.

"Our research documents a pathway by which the adipocytes participate in the immune response," Spurlock said. "We have very clearly shown that interferon-gamma is increasing expression of cytokines in pig fat cells."

In another part of the study, the researchers found that a molecule, or ligand, binds to molecules on the outside of pig fat cells incubated in a laboratory dish. In this case the ligand is an i
'"/>

Contact: Susan A. Steeves
ssteeves@purdue.edu
765-496-7481
Purdue University
20-Jan-2004


Page: 1 2 3

Related biology news :

1. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
2. Researchers develop fast track way to discover how cells are regulated
3. Chemical signals health of brain cells Symposium
4. New dye directly reveals activated proteins in living cells
5. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
6. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
7. Smac-ing back at cancer cells
8. Bone marrow cells routinely help with wound healing
9. Genuine stem cells found in skin might treat hair loss, wounds
10. Skin stem cells give hairless mice hair
11. Small, Smac-like molecule encourages death of cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... 30, 2017 Today, American Trucking Associations ... of face and eye tracking software, became the ... program. "Artificial intelligence and advanced ... monitor a driver,s attentiveness levels while on the ... to detect fatigue and prevent potential accidents, which ...
(Date:5/23/2017)... May 23, 2017  Hunova, the first robotic gym for the rehabilitation ... officially launched in Genoa, Italy . The first 30 ... and the USA . The technology was developed and ... by the IIT spin-off Movendo Technology thanks to a 10 million euro ... Release, please click: ...
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 11, 2017 , ... The CRISPR-Cas9 system has ... and avoiding the use of exogenous expression plasmids. The simplicity of programming this ... gain-of-function studies. , This complement to loss-of-function studies, such as with RNAi ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... announced today it will be hosting a Webinar titled, “Pathology is going digital. ... Associates , on digital pathology adoption best practices and how Proscia improves lab ...
(Date:10/11/2017)... ... , ... Disappearing forests and increased emissions are the main causes of the ... Especially those living in larger cities are affected by air pollution related diseases. , ... pollution-affected countries globally - decided to take action. , “I knew I had to ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... San Diego-based ... of its corporate rebranding initiative announced today. The bold new look is part ... as the company moves into a significant growth period. , It will also expand ...
Breaking Biology Technology:
Cached News: