HOME >> BIOLOGY >> NEWS
Fat cells heal skull defects in mice, Stanford research shows

w bone to bridge the defect. In contrast, cells derived from tissue that covers the brain showed no bone growth during the same time period.

The new bone growth began next to the brain, suggesting those cells were sending out bone growth-promoting signals and emphasizing the importance of the local environment in determining cell fate.

"The analogy is one of seeds and soil," said Longaker. "The cells are the seeds, and the soil that enables them to form bone consists of the scaffolding and the signals of neighboring cells."

Because more than 95 percent of the new bone growth was made up of implanted cells, researchers speculate the fat-derived cells either became bone themselves, as they have done in the laboratory, or fused with existing bone-making cells in the host to spur new growth.

If the researchers' findings can be reproduced in humans, they may lead to new, more effective and biologically gentle ways to promote healing of tricky fractures and skeletal defects.

"After age 2, you don't re-engineer a defect in your skull," said Longaker. "Currently, surgeons use bone grafts from the patient's ribs or split other parts of the skull horizontally to gain enough bone to cover the area. Alternatively, they can rely on plastic or metal inserts. But all of these options can give you problems with infection and healing, and can be invasive and technically difficult."

Other conditions that might benefit from the use of the multipotent cells include joint replacement, spinal fusion, osteoporosis and osteomyelitis, a bacterial infection of the bone.

"As more people are active in sports and live longer, the wear and tear on joints is obvious," said Longaker. "The non-human tissue we use to replace joints may last 10 to 20 years if it's well integrated. Our hope is that we could do better by replacing that with your own tissue. The key to this type of regenerative medicine is to understand the dev
'"/>

Contact: Robert Dicks
rdicks@stanfordmed.org
650-497-8364
Stanford University Medical Center
4-May-2004


Page: 1 2 3

Related biology news :

1. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
2. Researchers develop fast track way to discover how cells are regulated
3. Chemical signals health of brain cells Symposium
4. New dye directly reveals activated proteins in living cells
5. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
6. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
7. Smac-ing back at cancer cells
8. Bone marrow cells routinely help with wound healing
9. Genuine stem cells found in skin might treat hair loss, wounds
10. Skin stem cells give hairless mice hair
11. Small, Smac-like molecule encourages death of cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/31/2019)... (PRWEB) , ... December 31, 2019 , ... ... be an icon of its ecoregion, but researchers struggle to gather even basic ... and collect. The stool can be used to identify individual animals, allowing agencies ...
(Date:12/21/2019)... ... December 20, 2019 , ... The City of Tampa recently served ... on hand to honor these heroes. Tampa welcomed these most-highly decorated USA heroes as ... community leaders honored these distinguished service members. , The Medal of Honor, the USA ...
(Date:12/18/2019)... ... 18, 2019 , ... Intelligent.com, a trusted resource for online ... Biotechnology Degree Programs for 2020. The comprehensive research guide is based on an ... evaluated based on curriculum quality, graduation rate, reputation, and post-graduate employment. , ...
Breaking Biology News(10 mins):
(Date:1/7/2020)... ... January 06, 2020 , ... ... cohort of emerging biosciences ventures invited to participate in the annual program. Twelve ... fundable business plans and a professional network. All startups will receive an entrepreneur ...
(Date:12/27/2019)... ... December 27, 2019 , ... ... leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries ... new management . Following acquisition by CLJ Holdings in February, 2019, a comprehensive ...
(Date:12/18/2019)... ... 17, 2019 , ... Philadelphia IP law firm Panitch ... hired Dr. Alia Orbin, Ph.D., J.D., an experienced registered patent attorney with expertise ... prosecution of patent applications related to pharmaceutical sciences, organic and inorganic chemistry, biotechnology, ...
(Date:12/4/2019)... ... December 03, 2019 , ... A new survey by MedReps ( ... CONMED as the overall best medical sales companies to work for in 2020. ... polled over 1,200 professionals from the MedReps community to identify which medical sales companies ...
Breaking Biology Technology:
Cached News: