HOME >> BIOLOGY >> NEWS
Fat fighting undermined by over active eating pacemaker

Researchers at the University of Warwick have for the first time been able to detail how and why specific neurons in the brain control the hunger response. They have revealed a set of pacemaker nerve cells in the brain that appear to underlie the drive to feed which itself feeds on a complex web of signals. The level of complexity they have found is such that the system could be much more at risk of serious repercussions from a single error in how those signals are processed than anyone had previously thought. Any number of a range of errors could lead to over activity of these pacemaker cells and explain why many people find difficulty in eating less.

In the research, published in the May Issue of Nature Neuroscience, Dr David Spanswick and his research team in the University of Warwick's Department of Biological Sciences, looked at a part of the brain called the hypothalamic arcuate nucleus which was known to deal with hunger and satiety signals but how it achieves this is poorly understood. The University of Warwick team have identified very specific neurons that act as feeding "pacemakers".

This specific group of neurons- which they have dubbed the "ARC pacemaker" produce regular bursts of electrical activity. However these cells integrate and process a wide variety of signals indicating the energy needs of the body signals most often transmitted by the use of chemical messengers such as hormones like ghrelin, released from the gut and leptin from fat cells.

The combination of these signals and their integration by the ARC pacemaker is such a finely balanced mechanism that one small error or mutation leading to any inappropriate communication in these pathways could produce a significant untoward affect on human eating or feeding patterns.

The high number of potential ways that this delicately balanced hunger pacemaker can go wrong could explain why many overweight people are unable to address their weight problems by a combinati
'"/>

Contact: Dr. David Spanswick
D.C.Spanswick@warwick.ac.uk
44-0-24-76-574182
University of Warwick
11-May-2004


Page: 1 2

Related biology news :

1. White tea beats green tea in fighting germs
2. Researchers awarded $2 million to create high-tech tools for fighting wildfires
3. Armies of fighting fungi protect chocolate trees
4. Seed dormancy may hold the key to fighting weeds
5. Antibodies critical for fighting West Nile Virus infection
6. OXiGENE, foundation fighting blindness sign research agreement for phase I/II clinical trial
7. Rare disorder provides new insight into fighting infection
8. Cooking sweet corn boosts disease-fighting nutrients
9. New witchweed-fighting method, presented by CIMMYT and Weizmann Institute scientist
10. Tomato packs more cancer-fighting punch
11. Ramoplanin beats antibiotic resistance by fighting the battle on its own terms

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/18/2019)... ... March 18, 2019 , ... ... microbiome industry and the third highest quality portfolio following Seres Health and Nestle, ... Fankhauser, Christian Moser, and Theodor Myfleler. uBiome executives Dr. Jessica Richman, PhD, co-founder ...
(Date:3/14/2019)... ... 13, 2019 , ... Bode Technology (Bode), a leading provider of forensic DNA analysis ... sexual assault kits. As thousands of untested kits are identified across the country, Bode ... . Bode has tested more than 50,000 kits in the last three years alone. ...
(Date:3/12/2019)... ... March 12, 2019 , ... ... combined technology all-in-one smart cards, announced today the launch of two new payment ... Biometric and Dynamic CVV Payment cards. These advanced technologies will help all elements ...
Breaking Biology News(10 mins):
(Date:3/12/2019)... ... March 11, 2019 , ... ... in Colorado, and among the first in the nation, to offer needle-free blood ... IV placement and overall degree to which staff showed compassion jumped up by ...
(Date:3/9/2019)... SEATTLE (PRWEB) , ... March ... ... source for unbiased college rankings and higher education planning, announced the release ... identifies the top programs in the nation based on curriculum quality, program ...
(Date:2/27/2019)... ... February 26, 2019 , ... Superior Controls, Inc., ... solutions with 140 employees on both the east and west coasts, today announced ... State of New Hampshire. Sandmaier, a senior project engineer, joins Taggart McCormick, P.E., ...
(Date:2/19/2019)... ... February 19, 2019 , ... VetStem Biopharma has ... experience. In October 2018, VetStem authorized the formation of Personalized Stem Cells, Inc ... stem cell patents, data, and FDA filings to launch into human stem cell clinical ...
Breaking Biology Technology:
Cached News: