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Fat gene discovered

ression, Dr. Camp generated two cell populations: one lacking the gamma2 isoform and another lacking both isoforms. Similar to Dr. Spiegelman's results, both cell populations were unable to differentiate into fat cells.

In order to test exactly which isoform is responsible for fat cell differentiation, Dr. Camp selectively expressed either gamma1 or gamma2 in the cells that lacked both isoforms. She discovered that PPARgamma2 is singularly responsible for adipogenesis. Until now, the differential functions of these two isoforms had remained a mystery.


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Contact: Nora Poppito
poppito@cshl.org
Cold Spring Harbor Laboratory
31-Dec-2001


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