Fat hormone leptin alters brain architecture and activity, which in turn drives feeding behavior

c connections, and recordable changes in the electrical activity of specific brain cells.

Other researchers have shown that brain maps of cells can be quite plastic or changeable. Pinto, whose scientific training is in the area of learning and memory, wanted to know if the same was true when it came to feeding behavior.

"Feeding turns out to be a really good model to test plasticity because it's much simpler to study than the system that controls learning or memory," said Pinto.

For her research, Pinto used a famous mouse strain that resembles obesity in some humans. These mice lack leptin and grow to twice the size of a normal mouse with a body that contains five times the fat.

Using the obese mice, Pinto and her colleagues were able to show effects of the hormone on two particular sets of neurons: NPY and POMC. These neurons are found in the hypothalamus, an area of the brain that controls appetite. NPY stimulates food intake and increases body weight while one of the active products of POMC, a peptide called alpha-MSH, has the opposite effect. Pinto and colleagues discovered that leptin changes the number of connections that either excite or inhibit NPY and POMC neurons in the hypothalamus.

Led by Roseberry, the researchers also showed that leptin alters the electrical activity of the connections to NPY and POMC neurons. These effects are consistent with what the researchers found on the structural level.

In other words, leptin inhibits NPY neurons that encourage the animal to eat and reserve energy. At the same time the hormone activates POMC neurons that curtail feeding. And it does this by altering the synaptic inputs of these cells -- the points where the cells connect and communicate.

The Rockefeller scientists suggest that these leptin-induced structural and functional changes are responsible for changes in the animal's behavior, too.

Six hours after administering leptin to obese mice, ch

Contact: Lynn Love
Rockefeller University

Page: 1 2 3

Related biology news :

1. Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
2. Excess thyroid hormone harmful to fetus
3. Blood pressure hormone may inhibit growth of lung cancer
4. Hunt for a new plant hormone points to carotenoids
5. When male fish hum, females swim in, thanks to hormones, adaptable hearing
6. Evidence for fat hormone target in brain
7. Synthetic hormone used in contraceptives and HRT produces negative effects in monkey studies
8. Moderate alcohol consumption increases plasma levels of a protective hormone
9. Fat cell hormone causes weight loss
10. OHSU researchers discover possible connection between infant hormone exposure, obesity
11. Stress hormones and heart failure

Post Your Comments:

(Date:3/4/2020)... ... March 04, 2020 , ... RoosterBio Inc., a ... bioprocess systems, announces today a significant milestone in the regenerative medicine field with ... patient has been treated by RoosterBio’s pharmaceutical customer with an Investigational New Drug ...
(Date:3/3/2020)... ... March 03, 2020 , ... Board-certified oral and maxillofacial surgeon, Dr. Michael Noffze ... of training and experience, Dr. Noffze can successfully extract problem and impacted wisdom teeth ... possible is beneficial to the oral and overall health of most patients as these ...
(Date:3/2/2020)... ... 2020 , ... Philadelphia IP law firm Panitch Schwarze Belisario & Nadel LLP ... as a Partner, and Stephany G. Small, Ph.D., has joined the firm as a ... a partner in the firm’s biotechnology and life science practice group. He has significant ...
Breaking Biology News(10 mins):
(Date:2/3/2020)... ... February 03, 2020 , ... Global ... announce that OmniType, the 11-locus, single tube multiplex successor to Holotype HLA is ... product featuring locus-multiplexing and short library preparation, for HLA genotyping from sample to ...
(Date:1/28/2020)... ... January 28, 2020 , ... Genedata, the ... release of Genedata Expressionist ® 13.5 at the 2020 WCBP Symposium. ... (MAM) for characterizing and monitoring the quality of biopharmaceuticals throughout their development ...
(Date:1/27/2020)... (PRWEB) , ... January 27, 2020 , ... ... advances in neuroscience and cloud and mobile computing, today announced the availability of ... across an organization to use the latest neuroscience of leadership and change research ...
(Date:1/24/2020)... PLAINS, N.J. (PRWEB) , ... January 24, 2020 , ... ... at The Plastic Surgery Center in New Jersey epitomize the notion that plastic surgery ... surgery is typically characterized in popular media. , Over the last 20 years NJ ...
Breaking Biology Technology:
Cached News: