Fat hormone leptin alters brain architecture and activity, which in turn drives feeding behavior

anges could be seen in their synaptic connections. Forty-eight hours later, they were eating less and at 12 days the mice had lost weight.

Finally, the researchers also discovered that the same brain wiring system could be influenced with a separate substance -- a peptide called ghrelin, found in the stomach and the brain. In contrast to leptin, ghrelin stimulates appetite. Application of ghrelin was associated with an increase in the numbers of inhibitory synapses on the POMC neurons, suggesting that the effects of ghrelin and leptin on the neuronal circuits may be evidence of a more general phenomenon regulating feeding circuits. But unlike leptin, ghrelin induced feeding behavior in minutes. Leptin appears to have a slower, more long-term effect, Pinto said.

Leptin was originally identified by Friedman and his Rockefeller research colleagues in 1994. He identified the gene that produces this hormone, which he named for the Greek word leptos or thin.

Other researchers have shown that leptin-deficient humans are massively obese and become lean with leptin treatment. Under Friedman's direction, clinical research on human patients is also ongoing at The Rockefeller University Hospital. Doctors are assessing the effects of leptin in overweight patients (who are not leptin-deficient) who follow a very low calorie diet.

Xiaoli Cai of Rockefeller University contributed to this paper, as did Sabrina Diano and Marya Shanabrough of Yale University.


Contact: Lynn Love
Rockefeller University

Page: 1 2 3

Related biology news :

1. Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
2. Excess thyroid hormone harmful to fetus
3. Blood pressure hormone may inhibit growth of lung cancer
4. Hunt for a new plant hormone points to carotenoids
5. When male fish hum, females swim in, thanks to hormones, adaptable hearing
6. Evidence for fat hormone target in brain
7. Synthetic hormone used in contraceptives and HRT produces negative effects in monkey studies
8. Moderate alcohol consumption increases plasma levels of a protective hormone
9. Fat cell hormone causes weight loss
10. OHSU researchers discover possible connection between infant hormone exposure, obesity
11. Stress hormones and heart failure

Post Your Comments:

(Date:3/3/2020)... ... , ... Amplify Surgical, Inc., today announces that the company reached the milestone ... , The landmark case was performed by Dr. Ali Najafi at Fresno Heart and ... completely changed the game for expandable interbodies. The ability to achieve an ALIF ...
(Date:3/2/2020)... ... ... Toronto-based clinical research organization (CRO) and regulatory consulting firm, dicentra , has announced ... Clarksburg on a farm on Beaver Valley Road. , The owners currently operate an ... it would be a great new option for employees to relocate to. , “Part ...
(Date:3/2/2020)... (PRWEB) , ... March 02, 2020 , ... Nominations are ... program co-founded by the Security Industry Association (SIA) and SecureIDNews ... SIA Women in Security Forum . The recipients of this year’s Women in Biometrics ...
Breaking Biology News(10 mins):
(Date:3/3/2020)... ... March 03, 2020 , ... Frictionless Solutions, a ... device industries, was recognized by INC. 5,000 on an annual list of America’s ... industry leaders greatly impacting their spheres of influence and experiencing considerable development. INC. ...
(Date:3/2/2020)... ... ... McBee, Moore and Vanik IP, LLC (MMV IP) has been ranked 12th ... , According to statistics compiled by Harrity Anaytics, MMV IP was listed as the ... during 2019. Technology center 1600 at the US Patent Office (“USPTO”) specializes in the ...
(Date:2/26/2020)... ... February 25, 2020 , ... Continuing its leading research ... results of its safety assessment on the biotechnologically produced 3-Fucolsyllactose (3-FL) HMO. ... These complex carbohydrates are indigestible and therefore function as a prebiotic by promoting ...
(Date:2/21/2020)... ... February 20, 2020 , ... ... efficient and elegant chemistry. Humans have been increasingly successful in innovating ways ... Through rapidly evolving technologies and strategies for modern molecular biology (e.g., gene ...
Breaking Biology Technology:
Cached News: