Fatal thrombotic disease in designer mice lacking vascular thrombomodulin

The protein C pathway, which is initiated by the interaction of thrombin with the vascular surface protein thrombomodulin (TM), provides an important brake on blood clotting. Although defects in protein C, protein S, and clotting factor V, other players in this pathway, are known causes of thrombosis, the physiological role of TM in adult hemostasis has proved difficult to pin down, in part because TM serves an early, essential role in development. Indeed, Weiler and his colleagues have found that deletion of the Tm gene in mice causes early death of embryos and that the critical site of this proteins developmental function is not the blood vessel endothelium, but the placenta. Now the same group has used the Cre/LoxP system to generate mice lacking the Tm gene specifically in endothelial cells. Many of these mice survive gestation but develop flagrant thrombosis in early adulthood and eventually die with a consumptive coagulopathy. Continuous low-dose exposure to the coagulation inhibitor warfarin prevents these symptoms and allows mice to survive despite the lack of TM, confirming that the disease is one of uncontrolled thrombosis. Males and females show different rates of disease progression in this strain, but the basis of this effect and the possible relation with the coincidence of disease and sexual maturity remain mysterious.


Contact: John Ashkenas
Journal of Clinical Investigation

Page: 1

Related biology news :

1. Fatal attraction: Satellites to determine sea lions deaths
2. New Evidence On How Prions Turn Fatal
3. UF Researchers: Gene Therapy Replaces Critical Protein In Animal Model Of Often-Fatal Lung-Liver Disease
4. Scientists Find New Clues About Fatal Childhood Disease, Ataxia Telangiectasia
5. Fatal Frog Fungus Found In The United States
6. Florida Researchers Discover Gene For Fatal Childhood Disease
7. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
8. Alzheimers disease is not accelerated aging
9. New molecular link key to cellular proteins involved in cancer progression, other diseases
10. Wildlife Conservation Society hosts public symposium on human-wildlife diseases
11. University of Alberta researcher looks for clues to mysterious disease

Post Your Comments:

(Date:8/26/2020)... ... 2020 , ... Modality Solutions, a biopharmaceutical cold chain validation engineering ... The list is the most prestigious ranking of the nation’s fastest-growing private companies. Modality ... list, reported three-year revenue growth of 71 percent. , The Inc. 5000 list ...
(Date:8/21/2020)... ... August 19, 2020 , ... “How can we help?”, asks ... Salivary Bioscience for more than twenty years. Together with Douglas Granger, Ph.D., founder ... Bioscience: Foundations of Interdisciplinary Saliva Research and Applications ," and Steven Granger, Ph.D., ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... in Princeton, NJ, have entered into license agreements with Housey Pharma’s HMI subsidiary ... Both Roche and J&J have annual Research and Development spending in excess of ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics rebrands company ... Known as MediVet Biologics since its formation in 2016, the company is relaunching ... Health will build on its base of innovative therapies for osteoarthritis and cancer. ...
(Date:7/31/2020)... Mass. and SOMERSET, N.J (PRWEB) , ... July ... ... leading genome editing company, and Catalent, the leading global provider of advanced delivery ... consumer health products, today announced that they have entered into a strategic partnership ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery ... of a great surgery is only the beginning of a successful study, while protecting ... , Join Brad Gien, Global Head of Surgery from Envigo in a ...
(Date:7/10/2020)... (PRWEB) , ... July 09, ... ... biotechnology company, announced today that Massachusetts Institute of Technology (MIT) has expanded ... broader license allows PathSensors to move into the point-of-care diagnostic market, focusing ...
Breaking Biology Technology:
Cached News: