HOME >> BIOLOGY >> NEWS
Fauci: New Findings Help Explain "Rebound" Of HIV In Patients Who Discontinue Triple-Drug Therapy

esent his laboratory's new observations at the 5th Conference on Retroviruses and Opportunistic Infections in Chicago, Ill., on Wednesday, February 4 at 6:30 p.m. in the Sheraton Chicago Ballroom. The lecture is part of a special symposium chaired by Dr. Fauci called "Host Factors in HIV Infection: Implications for Therapy." The symposium also features Drs. Stephen O'Brien of the National Cancer Institute, Barton Haynes of the Duke University School of Medicine, and Giuseppe Pantaleo of Centre Hospitalier Universitaire Vaudois in Lausanne, Switzerland.

When an HIV-infected patient is taking HAART, inductive cytokines and other factors which can boost HIV production are still present in their lymph nodes and related organs. However, the powerful effects of HAART nonetheless can reduce viral replication dramatically, sometimes to the point where HIV can be found only in a latent form in resting CD4+ T cells. The new data suggest that when HAART is withdrawn, the effects of HIV-inducing cytokines and other factors once again promote the active production of virus.

"The findings underscore the risks involved in discontinuing antiretroviral therapy, even if a patient feels better and has a viral load that is 'undetectable' using standard assays," Dr. Fauci says. "Our data also stress the importance of developing comprehensive treatment strategies which not only block HIV replication but also modulate the host factors that drive such replication.

Background

In studies dating back to the mid-1980s, Dr. Fauci and his team have shown that certain cytokines normally secreted by immune cells, particularly in the lymph nodes, can boost the replication of HIV. Blocking these so c
'"/>

Contact: Greg Folkers
gfolkers@nih.gov
301-496-2263
NIH/National Institute of Allergy and Infectious Diseases
2-Feb-1998


Page: 1 2 3 4

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Findings redefine mechanism of action of RNA helicase enzymes
3. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
4. Findings could aid efforts to harness nature for making drugs
5. Findings offer clue to how molecule can both stimulate, suppress cell growth
6. Findings offer further understanding about growth and development in young male gymnasts
7. Findings in frog oocytes may help study of chromosome physiology
8. Findings aid understanding of neurodegenerative diseases
9. Findings show exceptional longevity runs in families
10. Findings give insight into how colon cells transform into precancerous polyps
11. Findings conclude sustained caffeine intake negates the benefits of creatine supplements

Post Your Comments:
(Date:4/8/2015)... , April 8, 2015  Infinisource, a leading ... services, and Morpho, a leading supplier of biometric ... produce the market,s most advanced biometrically-enabled time clock, ... NXG time clock is setting a bold, new ... data for the small and mid-size employer. When ...
(Date:4/2/2015)... , April 2, 2015 According ... 2015 attributed to somewhat higher than 125 MSEK. This ... year-end report 2014 that revenues for Q1 2015 would ... company reported for Q4 2014. The operating result for ... negative. The complete interim report will as previously communicated ...
(Date:3/31/2015)... NEW YORK , March 31, 2015  Elephant ... the "Company"), a global provider of Software Defined Network ... solutions, today announced total revenue of approximately $20.4 million ... to a restated $19.5 million for the year ended ... of calendar 2014, the Company had completed its multi-year ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Revises Revenues for Q1 2015 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6
(Date:4/24/2015)... April 24, 2015  Pfenex Inc. (NYSE MKT: PFNX) ... biosimilar therapeutics including high value and difficult to manufacture ... offering of 6,000,000 shares of its common stock at ... Of the shares being offered, 2,610,000 are being offered ... offered by existing stockholders. Pfenex will not receive any ...
(Date:4/24/2015)... 24 , 2015 PAREXEL International Corporation ... provider, today announced that Partnerships in Clinical Trials named ... the 2015 Clinical Innovator of the Year.  The honor ... for the Company,s Perceptive MyTrials ® Data-Driven Monitoring ... night during the 2015 Partnership Awards in ...
(Date:4/23/2015)... CA (PRWEB) April 23, 2015 Athena ... personal development of executive women in San Diego’s technology ... the 17th Annual Pinnacle Awards at their Gala on ... Hyatt Hotel. Register now at http://athenasd.org/events/ , ... support the Athena San Diego vision of fostering networking, ...
(Date:4/23/2015)... , April 23, 2015 BioTE Medical President ... book "Age Healthier Live Happier - Avoiding Over-Medication through ... Age Management Medicine Group Conference at JW Marriott / ... ",Age Healthier Live Happier, is a welcomed ... over-medication and searching for a higher quality of life ...
Breaking Biology Technology:Pfenex Inc. Announces Pricing Of Follow-on Offering 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 3PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 4PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 5Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3
Cached News: