HOME >> BIOLOGY >> NEWS
Fauci: New Findings Help Explain "Rebound" Of HIV In Patients Who Discontinue Triple-Drug Therapy

esent his laboratory's new observations at the 5th Conference on Retroviruses and Opportunistic Infections in Chicago, Ill., on Wednesday, February 4 at 6:30 p.m. in the Sheraton Chicago Ballroom. The lecture is part of a special symposium chaired by Dr. Fauci called "Host Factors in HIV Infection: Implications for Therapy." The symposium also features Drs. Stephen O'Brien of the National Cancer Institute, Barton Haynes of the Duke University School of Medicine, and Giuseppe Pantaleo of Centre Hospitalier Universitaire Vaudois in Lausanne, Switzerland.

When an HIV-infected patient is taking HAART, inductive cytokines and other factors which can boost HIV production are still present in their lymph nodes and related organs. However, the powerful effects of HAART nonetheless can reduce viral replication dramatically, sometimes to the point where HIV can be found only in a latent form in resting CD4+ T cells. The new data suggest that when HAART is withdrawn, the effects of HIV-inducing cytokines and other factors once again promote the active production of virus.

"The findings underscore the risks involved in discontinuing antiretroviral therapy, even if a patient feels better and has a viral load that is 'undetectable' using standard assays," Dr. Fauci says. "Our data also stress the importance of developing comprehensive treatment strategies which not only block HIV replication but also modulate the host factors that drive such replication.

Background

In studies dating back to the mid-1980s, Dr. Fauci and his team have shown that certain cytokines normally secreted by immune cells, particularly in the lymph nodes, can boost the replication of HIV. Blocking these so c
'"/>

Contact: Greg Folkers
gfolkers@nih.gov
301-496-2263
NIH/National Institute of Allergy and Infectious Diseases
2-Feb-1998


Page: 1 2 3 4

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Findings redefine mechanism of action of RNA helicase enzymes
3. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
4. Findings could aid efforts to harness nature for making drugs
5. Findings offer clue to how molecule can both stimulate, suppress cell growth
6. Findings offer further understanding about growth and development in young male gymnasts
7. Findings in frog oocytes may help study of chromosome physiology
8. Findings aid understanding of neurodegenerative diseases
9. Findings show exceptional longevity runs in families
10. Findings give insight into how colon cells transform into precancerous polyps
11. Findings conclude sustained caffeine intake negates the benefits of creatine supplements

Post Your Comments:
(Date:5/20/2015)... 2015 Research ... the addition of the  "5-year Opportunity ... Market"  report to their offering.  ,     ... analyses trends in the iris recognition ... sectors, globally. Despite hardware pricing and ...
(Date:5/18/2015)... 2015 Fingerprint Cards (FPC) has received ... FPC1155 and FPC1035 from one if its module partners. Deliveries ... Q3 2015 and the sensors will be used by smartphone ... for 2015 hereby amount to 740 MSEK to date. In ... MSEK and a number of smaller orders not separately communicated ...
(Date:5/11/2015)... , May 11, 2015 Curemark LLC, a ... start of a new Phase III double blind, randomized, ... novel formulation, CM-AT, on all children ages 3-8 with ... FDA Phase III double blinded clinical trial for CM-AT ... levels of the digestive enzyme chymotrypsin. This new trial ...
Breaking Biology News(10 mins):Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2
(Date:5/28/2015)... IN (PRWEB) May 28, 2015 The Academy ... National Model Aviation Day on August 15, 2015. National Model ... aviation nation-wide and to introduce model flying to the general ... 2,350 chartered clubs to participate in the celebration by hosting ... registered to host National Model Aviation Day events. View ...
(Date:5/28/2015)... May 28, 2015 DryLet, LLC ... in applications such as animal waste reduction, bioremediation, ... reduction in wastewater treatment plants and restaurant kitchen ... World Pork Expo, June 3-5 in Des Moines, ... in a Wall Street Journal article because of ...
(Date:5/28/2015)... RXi Pharmaceuticals Corporation (NASDAQ: RXII ), ... therapeutics, primarily in the areas of dermatology and ophthalmology, ... 26 million units at a price to the public ... $10.4 million. Each unit consists of (i) one share ... to purchase 0.50 of a share of common stock ...
(Date:5/28/2015)... and London (PRWEB) May 28, 2015 ... of Computer Aided Engineering software, announced today it ... Inc. (PSRI). CD-adapco will provide state-of-the-art engineering simulation ... will share their expertise and experiences in analyzing ... refining industry members and advance the understanding of ...
Breaking Biology Technology:Model flying pilots celebrate the Academy of Model Aeronautics Foundation’s Third Annual National Model Aviation Day 2DryLet to Showcase Patented ManureMagic™ at the 2015 World Pork Expo, June 3-5 in Des Moines, Iowa 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3CD-adapco and PSRI Chartering New Course in Particle Flow Simulations 2
Cached News: