alled "inductive" cytokines, such as tumor necrosis
factor-alpha (TNF-alpha), interleukin 1-beta (IL-1 beta), and interleukin-6 (IL-6), can markedly
reduce viral replication. Conversely, as LIR scientists first described in 1987, even resting,
latently infected cells can be induced to actively produce HIV when cytokines such as
TNF-alpha are added. More recent LIR experiments have shown that other stimuli, such as
the activation of immune system cells by immunization, can also induce latently infected
cells to actively produce HIV. In addition to these factors, a group of molecules called
CC-chemokines, which suppress the replication of certain strains of HIV, can enhance the
replication of HIV in some circumstances.
"HIV disease is a multifactorial process controlled by the complicated interplay of stimulatory
and inhibitory factors concentrated in the lymphoid tissue, the centers of immune activity in
the body," Dr. Fauci notes.
At the Chicago symposium, Dr. Fauci will present data from in vitro experiments involving
latently infected CD4+ T cells drawn from HIV-infected, HAART-treated individuals, as well
as from HIV-infected patients not receiving HAART.
In one series of experiments, the researchers found that after adding HAART to cultures of
latently infected, resting CD4+ T cells, they were unable to induce with cytokines the
production of HIV from the cells of either group of patients.
"However, when we took HAART out of the cultures, we were able to rapidly induce HIV
replication with cytokines, even in cells from patients who had been on HAART for many
months," says Dr. Fauci.
In another in vitro experiment, the researchers sought to determine if they coulPage: 1 2 3 4 Related biology news :1
Contact: Greg Folkers
NIH/National Institute of Allergy and Infectious Diseases
. Findings suggest need for new view of p53 cancer proteins interaction with DNA2
. Findings redefine mechanism of action of RNA helicase enzymes3
. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration4
. Findings could aid efforts to harness nature for making drugs5
. Findings offer clue to how molecule can both stimulate, suppress cell growth6
. Findings offer further understanding about growth and development in young male gymnasts7
. Findings in frog oocytes may help study of chromosome physiology8
. Findings aid understanding of neurodegenerative diseases9
. Findings show exceptional longevity runs in families10
. Findings give insight into how colon cells transform into precancerous polyps11
. Findings conclude sustained caffeine intake negates the benefits of creatine supplements