HOME >> BIOLOGY >> NEWS
Fauci To Present New Insights Into HIV Latency At 12th World AIDS Conference

During the past year, scientists have shown that HIV persists in a latent form within a relatively small number of resting CD4+ T cells, even in patients who have received prolonged combination antiretroviral therapy and have no readily detectable virus in their blood. Latently infected CD4+ T cells are potential sources of new viral replication if a patient stops therapy, and pose a formidable obstacle to the goal of eradicating HIV from a person's body, particularly if drug resistance develops.

New data show that latent pools of infected cells are established very early in the course of HIV infection, even if a patient is treated expeditiously with highly active antiretroviral therapy ("HAART" - generally a three- or four-drug combination that includes a protease inhibitor). Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID) and chief of the NIAID Laboratory of Immunoregulation (LIR), will present these and other new findings at the 12th World AIDS Conference in Geneva, Switzerland.

"We have shown that initiating HAART as soon as 10 days after the onset of the symptoms of acute HIV infection does not prevent the formation of a latent reservoir of virus," says Dr. Fauci. "By the time high levels of HIV are detectable in the blood, the virus probably has spread to the lymphoid organs and established a pool of latently infected cells.

"Our group and others are pursuing studies to identify and treat people recently exposed to HIV, before the burst of virus replication, which occurs in most patients soon after infection. Such studies will help determine whether it will be possible to prevent the early establishment of latent pools of HIV."

In Geneva, Dr. Fauci also will discuss the potential for diminishing latent pools of HIV - the possibility of "flushing out" the virus (at least in the test tube) - by stimulating latently infected CD4+ T cells with antibodies to the CD3 molecule on the cell
'"/>

Contact: Greg Folkers
gfolkers@nih.gov
(301) 496-2263
NIH/National Institute of Allergy and Infectious Diseases
30-Jun-1998


Page: 1 2 3

Related biology news :

1. Fauci: New Findings Help Explain "Rebound" Of HIV In Patients Who Discontinue Triple-Drug Therapy
2. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
3. Presentation of Dr. Ingo Potrykus July 21 in Providence
4. Renowned Prostate Cancer Experts Present Latest Findings At UCSF Cancer Center Symposium
5. Echinacea Symposium Presents New Research On Chernobyl Victims
6. Cedars-Sinai Medical Center Physicians And Scientists Present Findings At Annual Meeting Of The Pediatric Academic Societies
7. Virginia Tech Research Group Presents Improved Dental Materials
8. Nations Leading Biomedical Researchers Present Breakthroughs in Liver Disease
9. USGS To Present Diverse Research At ESA Annual Meeting
10. Chern Memorial Award Presented To Wistar Institute Postdoctoral Fellow
11. Neurons Control Brain Immunity: Neurotrophins As Regulators Of Antigen-Presentation In Microglial Cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/19/2020)... ... June 18, 2020 , ... ... Lab with Software for Data Decisions,” for pharmaceutical and biotech executives, laboratory ... and automate cutting-edge scientific instruments and laboratory equipment from dozens of manufacturers ...
(Date:6/11/2020)... ... 2020 , ... Cryo-Cell International’s announcement comes on the heel ... the medical field. The face masks will be distributed nationwide to obstetrical and ... to provide healthcare to pregnant women. The delivery of masks is scheduled to ...
(Date:6/5/2020)... ... June 04, 2020 , ... “Although we are disappointed to have to make ... staff, and the public. We remain committed to creating a global platform to ... said Julie Sutcliffe, President of WMIS. , The abstract deadline for ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management and ... it did not take off as quickly as people initially expected, and where eSource ... capturing data electronically for clinical trials and then repurposing it for downstream analysis, at ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... sciences industry, today announced the release of its signature product called Beacon ... Liaisons (MSLs) and other field medical professionals. , Beacon helps MSLs ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter implantation, ... surgery is only the beginning of a successful study, while protecting and accessing the ... Gien, Global Head of Surgery from Envigo in a live webinar ...
(Date:7/18/2020)... ... 16, 2020 , ... Medial EarlySign , a leader ... of high-burden diseases, and Centric Consulting, a business and technology consulting firm, today ... data in order to identify and prioritize patients for care. , Combining Centric’s ...
Breaking Biology Technology:
Cached News: