HOME >> BIOLOGY >> NEWS
Fauci To Present New Insights Into HIV Latency At 12th World AIDS Conference

During the past year, scientists have shown that HIV persists in a latent form within a relatively small number of resting CD4+ T cells, even in patients who have received prolonged combination antiretroviral therapy and have no readily detectable virus in their blood. Latently infected CD4+ T cells are potential sources of new viral replication if a patient stops therapy, and pose a formidable obstacle to the goal of eradicating HIV from a person's body, particularly if drug resistance develops.

New data show that latent pools of infected cells are established very early in the course of HIV infection, even if a patient is treated expeditiously with highly active antiretroviral therapy ("HAART" - generally a three- or four-drug combination that includes a protease inhibitor). Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID) and chief of the NIAID Laboratory of Immunoregulation (LIR), will present these and other new findings at the 12th World AIDS Conference in Geneva, Switzerland.

"We have shown that initiating HAART as soon as 10 days after the onset of the symptoms of acute HIV infection does not prevent the formation of a latent reservoir of virus," says Dr. Fauci. "By the time high levels of HIV are detectable in the blood, the virus probably has spread to the lymphoid organs and established a pool of latently infected cells.

"Our group and others are pursuing studies to identify and treat people recently exposed to HIV, before the burst of virus replication, which occurs in most patients soon after infection. Such studies will help determine whether it will be possible to prevent the early establishment of latent pools of HIV."

In Geneva, Dr. Fauci also will discuss the potential for diminishing latent pools of HIV - the possibility of "flushing out" the virus (at least in the test tube) - by stimulating latently infected CD4+ T cells with antibodies to the CD3 molecule on the cell
'"/>

Contact: Greg Folkers
gfolkers@nih.gov
(301) 496-2263
NIH/National Institute of Allergy and Infectious Diseases
30-Jun-1998


Page: 1 2 3

Related biology news :

1. Fauci: New Findings Help Explain "Rebound" Of HIV In Patients Who Discontinue Triple-Drug Therapy
2. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
3. Presentation of Dr. Ingo Potrykus July 21 in Providence
4. Renowned Prostate Cancer Experts Present Latest Findings At UCSF Cancer Center Symposium
5. Echinacea Symposium Presents New Research On Chernobyl Victims
6. Cedars-Sinai Medical Center Physicians And Scientists Present Findings At Annual Meeting Of The Pediatric Academic Societies
7. Virginia Tech Research Group Presents Improved Dental Materials
8. Nations Leading Biomedical Researchers Present Breakthroughs in Liver Disease
9. USGS To Present Diverse Research At ESA Annual Meeting
10. Chern Memorial Award Presented To Wistar Institute Postdoctoral Fellow
11. Neurons Control Brain Immunity: Neurotrophins As Regulators Of Antigen-Presentation In Microglial Cells

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Fauci Present New Insights Into HIV Latency World AIDS Conference

(Date:7/30/2014)... Press (OUP) is pleased to announce its new relationship ... 2015, OUP and CINP will partner to publish ... a fully open-access journal. , Alan Frazer, Editor-in-Chief of ... size and expertise of OUP will further facilitate the ... of the very leading journals within neuropsychopharmacology. The conversion ...
(Date:7/30/2014)... of $1 million from the Cornelia Cogswell Rossi Foundation ... Center. , The newly established Connie Cogswell ... develop a greater breadth and depth of knowledge of ... pace of research to improve human health. , The ... the Laboratory and its external partners, supporting research to ...
(Date:7/30/2014)... from HIV infection could be as simple as inserting ... , University of Washington bioengineers have discovered a potentially ... women from contracting HIV. Their method spins the drug ... with moisture, releasing higher doses of the drug than ... creams. , "This could offer women a potentially more ...
Breaking Biology News(10 mins):OUP to partner with the International College of Neuropsychopharmacology 2Rossi Foundation pledges $1M for JAX neurobehavioral research center 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 3
(Date:7/31/2014)... Graphite Metallizing Corporation announces GRAPHALLOY® ... These bearings are uniquely suited to prevent loss of ... of the high temperatures . , Recently, a ... design engineers at Graphite Metallizing to overcome problems with ... manufacturing operation, pans containing blocks of powder mixture are ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 CollabRx, Inc. ... inform therapeutic decision-making in oncology, today announced that it ... 2014 to discuss the Company's financial results for the ... update about the business in the current fiscal year. ... beginning on Thursday, August 14, 2014, at 5 p.m. ...
(Date:7/31/2014)... 31, 2014 Held at the Stanford ... an overview of the disease and its treatment. Survivors ... effects, as well as updates on the state-of-the-art with ... Sandy Srinivas for organizing this educational opportunity,” says KCA ... “Sandy and her colleagues have put together a program ...
(Date:7/31/2014)... 31, 2014 “Rapid technological advances ... the U.S., increasing unemployment, depressing American consumer spending ... is a Catch 22—we need automated manufacturing if ... fewer jobs,” says economist and corporate relocation expert ... Top 10 Pro-Business States for 2014, co-published with ...
Breaking Biology Technology:Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4
Cached News: