HOME >> BIOLOGY >> NEWS
Faulty DNA replication linked to neurological diseases

Lengthy sequences of DNA -- with their component triplet of nucleotides repeated hundreds, even thousands of times -- are known to be abnormal, causing rare but devastating neurological diseases. But how does the DNA get this way? How does it go haywire, multiplying out of control?

In the current issue of Molecular and Cellular Biology, Sergei Mirkin, professor of biochemistry and molecular genetics at the University of Illinois at Chicago College of Medicine, explains the mechanism, providing an important clue to the origin of these diseases.

Mirkin and Maria Krasilnikova, a research assistant professor in his lab, studied the sequence of a simple repeat of three nucleotides responsible for Friedreich's ataxia, the most commonly inherited form of ataxias, which causes progressive damage to the nervous system, resulting in symptoms ranging from muscle weakness and speech problems to heart disease.

The DNA triplet that repeats in Friedreich's ataxia is a guanine and two adenines (GAA) on one DNA strand and the complementary two thymines and a cytosine (TTC) on the opposite strand.

Earlier research had shown that up to 40 repeats of this nucleotide triplet do not cause any symptoms. The DNA is inherited as is, an odd but harmless pattern passed down from one generation to the next.

The problems begin when the repeats exceed 40.

"For Friedreich's ataxia and other neurological diseases, when the number of repeats exceeds 40, the sequence becomes unstable. That means that as the sequence is passed from one generation to the next, it gets longer. The longer it gets, the more likely it will get still longer. And the longer it gets, the worse the disease," Mirkin said. "Basically, even if you are more or less okay, there is a probability that your kids will be sick and a still higher probability that your grandkids will be even sicker."

To study how and why the inherited sequence expands so rapidly, the scientists wat
'"/>

Contact: Sharon Butler
sbutler@uic.edu
312-355-2522
University of Illinois at Chicago
4-Mar-2004


Page: 1 2 3

Related biology news :

1. Faulty practices threaten condor program
2. Researchers Discover How The Immune System Shuts Down Faulty T Cells
3. University Of Pittsburgh Cancer Institute Team Is The First To Uncover Role Of Faulty DNA Repair In Breast Cancer
4. Duke Researchers Show "Editing" Can Fix Faulty Genes In New Approach To Gene Therapy
5. New sequence involved in DNA replication timing may aid in cancer detection
6. How an insidious mutation fools DNA replication
7. Researchers in UGA Vet School discover a mechanism that blocks replication of a retrovirus
8. HIV protein attacks bodys innate protection system that could prevent virus replication
9. UGA scientists discover gene that maintains genome integrity by limiting DNA replication
10. Molecular motor drives rotavirus replication
11. Manganese blocks HIV replication; Lab finding points to potential new class of HIV treatments

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Faulty DNA replication linked neurological diseases

(Date:3/26/2015)... , March 26, 2015 ... family, social, recreation and athletic club, today announced it ... to allow freedom of movement for members and staff, ... "Following a comprehensive process, we selected FST,s IMID Access ... and convenience for our members and staff, in addition ...
(Date:3/24/2015)... 2015   NexID Biometrics LLC, whose spoof-mitigation ... today announced the beginning of shipments of version 2.0 ... The company, based in Potsdam, N.Y. ... Expo, which began here today at the Walter E. ... of its SDK boosts the accuracy rate range to ...
(Date:3/23/2015)... 23, 2015   HOYOS Labs , a leading ... announced that the Company will demonstrate multiple biometrics-based technologies ... consumers at Connect:ID on March 23 through 25, 2015, ... will highlight the IEEE Biometric Open Protocol Standard; free ... enterprise access control system. BOPS was invented by HOYOS ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
(Date:4/1/2015)... National recruitment firm Slone Partners is ... Head of Sales at Optimal Medicine, an international digital ... Allen brings over 20 years experience in healthcare information ... companies including Dell Services Healthcare, Medsphere Systems and McKesson. ... fit for accomplishing the goals Optimal Medicine had for ...
(Date:3/31/2015)... March 31, 2015 CytoSorbents Corporation (NASDAQ ... blood purification to treat critically-ill and cardiac surgery ... summary and reports financial results for the fiscal ... 2014 CytoSorb® product revenues were a record $3.1M, ... 2013 CytoSorb® revenues of $0.8M Highlights for the ...
(Date:3/31/2015)... VANCOUVER , March 31, 2015  /PRNewswire/ ... announced today that it has filed with the Food ... New Drug ("IND") application related to the Company,s proposed ... of the IND application is required in order for ... US.  The IND application is a ...
(Date:3/31/2015)... , March 31, 2015 Materials ... ,   June 30 2015   ... information products and services and publishing home of Materials ... has launched the Materials in Society  Lecture Series ... the 8 th International Conference on Materials for ...
Breaking Biology Technology:Slone Partners Fills Head of Sales at Optimal Medicine 2CytoSorbents Reports Record 2014 Revenue 2CytoSorbents Reports Record 2014 Revenue 3CytoSorbents Reports Record 2014 Revenue 4CytoSorbents Reports Record 2014 Revenue 5CytoSorbents Reports Record 2014 Revenue 6CytoSorbents Reports Record 2014 Revenue 7CytoSorbents Reports Record 2014 Revenue 8CytoSorbents Reports Record 2014 Revenue 9CytoSorbents Reports Record 2014 Revenue 10CytoSorbents Reports Record 2014 Revenue 11ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 2ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 3ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 4Elsevier Materials Science Council Introduces the Materials in Society Lecture Series at the International Conference on Materials for Advanced Technologies (ICMAT) 2Elsevier Materials Science Council Introduces the Materials in Society Lecture Series at the International Conference on Materials for Advanced Technologies (ICMAT) 3
Cached News: