HOME >> BIOLOGY >> NEWS
Fears of second-hand smoke confirmed

July 29, 2003 -- Bethesda, MD -- Cigarette smoke is the major cause of pulmonary emphysema. This disease involves severe damage to the walls of the air sacs (alveoli), causing the lungs to lose their capacity to expand and contract (loss of elasticity). At that point, the air sacs are unable to completely deflate and are therefore unable to fill with fresh air for adequate ventilation. Two of every 1,000 Americans develop this disease. Scientists know smokers are significantly more likely to develop emphysema compared with nonsmokers, and the seriousness of the disease is directly correlated with the amount of cigarette smoking.

But why cigarette smoke leads to this disease is still open to speculation. Now, a team of researchers from Italy has found that cigarette smoke is a potent source of oxidative stress, DNA damage, and apoptosis for HFL-1 (fibroblast) cells, and is most likely the trigger leading to the development of pulmonary emphysema in smokers' lungs.

Their findings confirm the fears of many in a work and social environment that exposure to second-hand smoke can lead to a deadly and debilitating disease.

Background

Among the different toxic effects of cigarette smoke on human tissues, oxidation of structural and functional molecules and modulation of cell turnover play a major role. One study has hypothesized that cigarette smoke may act by decreasing the expression of vascular endothelial growth factor (VEGF) and its type 2 receptor, thus resulting in lung septal endothelial cell death. Because fibroblasts (stellate or spindle-shaped cells with cytoplasmic processes present in connective tissue) play a pivotal role in remodeling of pulmonary tissue, researchers have exposed fibroblasts to cigarette smoke and have studied two important processes: oxidative stress and apoptosis.

Oxidative stress is a disturbance in the oxidant-antioxidant balance, resulting in potential cell damage. It is involved in many biolog
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
29-Jul-2003


Page: 1 2 3 4

Related biology news :

1. Fears grow over mad elk disease
2. Fears over ICSI largely groundless say fertility experts
3. Fears of gene-therapy DNA passed to next generation statistically unfounded: Penn geneticists estimates affect FDA gene-therapy policy
4. UCR study says second-hand smoke affects healing
5. Prenatal exposure to second-handsmoke greater for disadvantaged children, study finds
6. Exposures to second-hand smoke lower than believed, ORNL study finds
7. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
8. Wildland fires: After the smoke clears
9. Current smoke alarms pass life-saving tests
10. Physician experts available to speak on California fires and smoke inhalation
11. New technology helps fire managers anticipate smoke problems

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/18/2018)... ... October 18, 2018 , ... TopConsumerReviews.com ... services that offer direct-to-consumer DNA Testing for health and/or genealogy research purposes. , ... reasons are many: some people want to find out more about their ancestry, ...
(Date:10/18/2018)... ... 18, 2018 , ... Learning hands-on genetic engineering skills just ... beginner’s guide to genetic engineering. "Zero to Genetic Engineering Hero: The beginner’s ... for teenagers, families, teachers, and classrooms to acquire university-level genetic engineering skills without ...
(Date:10/17/2018)... ... October 17, 2018 , ... ... life sciences, diagnostics, and scientific healthcare companies, proudly announces Insights: Scientific Healthcare ... South San Francisco. In conjunction with co-producer Biocom, the association representing the ...
Breaking Biology News(10 mins):
(Date:10/16/2018)... ... 15, 2018 , ... The American Medical Informatics Association (AMIA) is proud to ... awards at the AMIA 2018 Annual Symposium , taking place Nov. 3 – ... year garnered more than 700 submissions. The AMIA Signature Awards program provides an opportunity ...
(Date:10/11/2018)... , ... October 11, 2018 , ... ... label printing and software solutions, in collaboration with HP, the global leader in ... Avery UltraDuty GHS Chemical Labels on all HP PageWide Printers. , The award-winning ...
(Date:10/5/2018)... ... October 04, 2018 , ... ... identity and website that elevates the company’s brand identity and better reflects its ... offers a broader range of engineering expertise and related support services to clients ...
(Date:10/2/2018)... ... October 02, 2018 , ... ... contamination endangers the reliability and reproducibility of experimental data. Each lab must consider ... this educational webinar, which is sponsored by Eppendorf , attendees will learn ...
Breaking Biology Technology:
Cached News: