HOME >> BIOLOGY >> NEWS
Fertility study shows increased estrogen shortens window of implantation in mice

VANDERBILT One of the most vexing causes of infertility is the failure of the embryo to implant in the uterus. It's estimated that roughly three-quarters of all embryos fail to implant properly. And in those women being treated for infertility, even when healthy embryos are transplanted the failure rate is high: up to 70 percent fail to dock successfully in the uterine lining.

The interplay of signals between embryo and uterus during implantation is complex, yet recent findings by a group of Vanderbilt researchers may provide clues to better understand it. The group, led by S.K. Dey, Ph.D., Dorothy Overall Wells Professor of Pediatrics and Cell & Developmental Biology, has found evidence in mice suggesting that estrogen plays a critical role in determining the window of uterine receptivity for embryo implantation.

A report of the researchers' work, which could have implications for improving human fertility, currently appears in the online version of the journal Proceedings of the National Academy of Sciences, USA.

The studies show that too much estrogen alters expression of implantation-related genes in the uterus, which can rapidly abolish uterine receptivity to the embryo. Moreover, the amount of estrogen sufficient to elicit these changes is very small.

"The most exciting aspect of this investigation is that a very narrow range of estrogen levels can alter embryo implantation and gene expression," said Dey, who is also head of the division of Reproductive and Developmental Biology. "We're talking about nanogram levels here, which I would consider to be almost physiological doses in the mouse."

For their studies, the scientists allowed mice to copulate, then removed the ovaries of female mice to halt normal production of estrogen and progesterone, both of which are required for implantation to occur. Daily doses of progesterone kept the mice in a state of "delayed implantation," where any developing embryo, or blastocyst,
'"/>

Contact: Clinton Colmenares
clinton.colmenares@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
10-Feb-2003


Page: 1 2 3

Related biology news :

1. Fertility treatments increase incidence of twins at a cost
2. Fertility experts urge clinics to consider natural cycle IVF instead of routine use of ovarian stimulants
3. Discovery Of Mutation May Lead To Help For Male Fertility Problems
4. Research Suggests New Way To Gauge A Womans Fertility
5. Sperm Protein May Hold Clues For Fertility And Contraceptives
6. UB Fertility Researchers Find They Can Predict Pregnancy By Assessing Two Sperm Abnormalities
7. Poetically Timed With Spring, Budding Yeast Yield Possible Insight Into Male Fertility--And Infertility
8. Discovery By Fertility Specialist Offers Promise Of Reducing Multiple BirthsTied To Fertility Treatment
9. Student science contest participation influences study, career choices, alumni say
10. New study shows hope for treating inhalant abuse
11. International study findings link acne-like rash to effectiveness of new targeted cancer treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2019)... ... June 25, 2019 , ... ... Using 23andMe raw data, easily available from 23andMe, customers can get access to ... service is available for both 23andMe Ancestry and Health + Ancestry customers., With ...
(Date:6/16/2019)... , ... June 14, 2019 , ... ... invited to lecture at the fifth annual Neodent World Congress. Attended by thousands ... innovative progress and latest advancements in the world of dentistry. The three-day event ...
(Date:6/11/2019)... ... June 12, 2019 , ... With a rapidly growing ... leverage the Geneious Biologics platform as a premium hub for bioinformatics and computer ... says: “The Geneious team has done an excellent job accommodating our specific data, ...
Breaking Biology News(10 mins):
(Date:6/12/2019)... EGG HARBOR TOWNSHIP, N.J. (PRWEB) , ... June ... ... premier manufacturer of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, ... partnership agreement with Shanghai Zillion has been signed. The agreement will grant exclusive ...
(Date:6/11/2019)... CITY, Calif. (PRWEB) , ... June 10, 2019 ... ... (IOPP) today announced IOPP will add 80 of its scientific journals to DeepDyve’s ... of physics-related content to DeepDyve’s continually expanding library of more than 20 million ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released ... cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their gene ... MSC-EVs also increased the cells’ ability to lodge into bone marrow. This research ...
(Date:5/31/2019)... (PRWEB) , ... May 29, ... ... our patent applications from the USPTO providing proprietary interest to our methodology, ... FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including our ...
Breaking Biology Technology:
Cached News: