Fetal Lead Exposure May Reduce Immunity

ITHACA, N.Y. -- Lead in the drinking water of pregnant rats causes long-term damage to the immune systems of their offspring, according to studies at the Cornell University Institute for Comparative and Environmental Toxicology.

If the finding also holds true for pregnant women exposed to lead, it could help explain why some babies are born with a lifelong predisposition to asthma and other allergies, as well as cancers, say Cornell scientists who report the discovery in the current issue of the journal Toxicological Sciences (Vol. 42, pp. 129-135).

"We found that low levels of lead in embryos -- levels that do not affect the mother's immune system -- produce serious long-term immune system defects as the young rats mature," says Rodney R. Dietert, professor of immunotoxicology in Cornell's College of Veterinary Medicine. "These are immune changes that could increase their risk for allergic disease while reducing their immunity to tumors."

The Cornell researchers are now conducting parallel studies on early lead exposure with embryonic chickens as animal models, but have no plans to extend the studies at the university to humans. But humans subjects, they say, would not be hard to find.

"Unfortunately, pregnant women even in this country are exposed to these levels of lead through drinking water, old paint and other sources," Dietert said. "And the situation is worse in developing countries, where leaded gasoline is still sold and women work in factories where lead is used."

Lead exposure is just one of the risk factors for immune-related disease now under consideration by epidemiologists in the United States. Among other possible risk factors is early exposure to airborne particles, such as those found in air polluted with diesel engine fumes.

Studies at the Cornell toxicology institute and the university's veterinary college used Fischer 334 rats, a standard animal model for human cancer studies. The pregnant rats were given d

Contact: Roger Segelken
Cornell University News Service

Page: 1 2 3

Related biology news :

1. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
2. Fetal death, miscarriage linked to genetic mutation
3. CDC MMWR: Fetal Alcohol Syndrome and Cutaneous Anthrax in a Lab Worker
4. Fetal research first in USA
5. Fetal and prepubertal growth both programme cholesterol metabolism in adulthood
6. Fetal and birth complications increase mental illness risks
7. Functional Arteries Grown From Cells Using Novel System That Simulates Fetal Environment
8. Study Suggests Maternal Stress And Stress Hormones May Influence Fetal Brain Development In Utero
9. Maternal Anxiety May Affect Fetal Development
10. Fetal Surgery For Spina Bifida Still Under Investigation At VUMC
11. Fetal Growth Rate Affects Risk Of Heart Disease

Post Your Comments:

(Date:5/2/2019)... Hungary and CAMBRIDGE, Mass. (PRWEB) , ... April ... ... in Budapest with US offices in Cambridge, MA, announces today that Holotype HLA ... annual meeting of the European Federation for Immunogenetics (EFI) in Lisbon, ...
(Date:5/2/2019)... ... May 01, 2019 , ... ... Directors has appointed John Rakow, the Company’s General Counsel, as Interim Chief Executive ... Zac Apte, are currently on administrative leave. There will also be an independent ...
(Date:4/27/2019)... , ... April 26, 2019 , ... ... Plan Competition on Thursday, April 25. More than 30 student venture teams, representing ... prizes totaling more than $75,000. , The top five teams in the ...
Breaking Biology News(10 mins):
(Date:4/10/2019)... ... April 10, 2019 , ... ... medicine manufacturing technology leaders, have locked into multiple agreements to help companies ... across the regenerative medicine industry, ranging from synthetic biology companies that are ...
(Date:4/9/2019)... SANTA BARBARA, Calif. (PRWEB) , ... April 09, ... ... global professional services firm focused on increasing the capacity of life sciences organizations ... to its Cloud Assurance platform in the past 12 months. , ...
(Date:4/9/2019)... ... April 09, 2019 , ... The American Society ... of the Society's leadership team, including a new addition to the presidential line of ... their peers to join the Society's leadership team for a three-year term (2019-2021). , ...
(Date:4/8/2019)... ... April 08, 2019 , ... US Capital Global ... $15 million preferred equity investment in the privately held pharmaceutical company, S1 Biopharma (“S1”). ... Lorexys, is targeted at female hypoactive sexual dysfunction disorder and is ready to begin ...
Breaking Biology Technology:
Cached News: