HOME >> BIOLOGY >> NEWS
Fighting Fungi

Scientists from Howard Hughes Medical Institute in Ann Arbor, Michigan have made a discovery that may help us win the biomedical war against fungal pathogens. As published in Genes & Development, Dr. Martin Schrder and colleagues have uncovered a specific biological program which prevents the development of the pathogenic form of several fungi, and have thus paved the way for the design of new anti-fungal agents. Depending upon nutrient availability, many fungi are able to switch between two different morphological forms: a unicellular yeast form and a multicellular filament form. For a number of medically and agriculturally relevant fungi, the filament form is necessary for pathogenicity.

Ustilago maydis, Cryptococcus neoformans, and Candida albicans may not sound familiar, but the effects of these fungi certainly are. Well known to any farmer, Ustilago maydis is the cause of corn smut disease. Cryptococcus neoformans is responsible for meningitis. Candida albicans, the most prevalent yeast species in the human GI tract, causes vaginal yeast infections, oral thrush, and can invade tissues and produces fatal systemic infections in immunocompromised people. Under nitrogen-poor conditions, each of these fungi switch to filament form and thus become pathogenic. This physiological response to nutrient availability has been well documented. It is only now beginning to be understood.

Schrder and colleagues have discovered that the unfolded protein response (UPR) mediates this morphological response. The UPR is a cellular stress response, conserved from yeast to humans. Normally, proteins are folded into their proper conformations in the endoplasmic reticulum (ER) compartment of a cell. When unfolded or misfolded proteins accumulate in the ER, the UPR is activated to transiently decrease the level of protein production and ensure that proper folding occurs. Schrder and colleagues have demonstrated that an active UPR represses filament formation. Their experi
'"/>

Contact: Nora Poppito
poppito@cshl.org
Cold Spring Harbor Laboratory
30-Nov-2000


Page: 1 2

Related biology news :

1. Fighting Mycobacterium tuberculosis with structural proteomics
2. Fighting fire with fire? Vaccine based on chimp virus shows promise against HIV
3. Fighting the spread of sudden oak death
4. Fighting the battle of the bulge in children
5. Fighting breast cancer at the molecular level
6. Fighting skin cancers with computers and technology
7. Fighting diabetes: UD researchers move closer to chip-based control of smart, implantable insulin pumps
8. Trash From Crop-Processing Plant Harvested For Disease-Fighting Agents
9. Studies At Cedars-Sinai Confirm Identity Of An Elusive Receptor In Human Cells -- A Breakthrough In Understanding, Fighting Septic Shock
10. Chemical Contaminants May Inhibit Cancer-Fighting White Blood Cells
11. Radioactive Beads Latest Weapon In Fighting Cancer In Dogs, Cats

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... TORONTO (PRWEB) , ... June 04, 2019 , ... ... automate the search for salient features of seizure risk signals, usually based on ... neurologist-driven EEG interpretation remains the only acceptable diagnostic methodology due to the complexity ...
(Date:6/1/2019)... ... May 31, 2019 , ... ... & Rosati recently invested in BioFactura’s $6M Series B Financing Round. , ... value-added institutional investors who bring significant financial and business resources to bear as ...
(Date:5/31/2019)... ... 30, 2019 , ... Join Julie Peacock, Vice President of ... Wednesday, June 19, 2019 at 1pm EDT where she will demonstrate how role-based ... and contract research organizations (CROs) can improve collaboration, auditing, document tracking and reporting. ...
Breaking Biology News(10 mins):
(Date:5/22/2019)... ... May 22, 2019 , ... Artemis (formerly ... $8 million Series A funding round co-led by Astanor Ventures and ... Development Fund and iSelect Fund . The company has raised $11.75m to ...
(Date:5/15/2019)... ... May 16, 2019 , ... Emulsifiers are the ... and beverage products rely on these ingredients to create stable quality food that ... This paradigm shift triggers food formulators to seek out alternatives for starches, gums ...
(Date:5/8/2019)... , ... May 07, 2019 , ... Standing at 16.2 hands, Atlas is on the ... in a drill team and barrel racing, among other activities. When loping around a ... He went from being a busy horse to only being able to walk. Fortunately ...
(Date:5/4/2019)... , ... May 03, 2019 , ... ... release of the Diopsys® ffERG/Photopic Negative Response vision test, a new ... By 2050, it is estimated that 6.3 million Americans will have glaucoma, with ...
Breaking Biology Technology:
Cached News: