Fighting Mycobacterium tuberculosis with structural proteomics

Tuberculosis is one of the deadliest threats to public health today. An estimated two billion people are infected with Mycobacterium tuberculosis (Mtb), with eight million new cases annually and two million people dying from the infection each year. The situation is further aggravated by the lethal alliance of HIV and Mtb co-infection. HIV patients have weakened immune systems, making them more susceptible to secondary infections and about one-third of HIV patients die from tuberculosis.

The most effective Mtb-specific antibiotics were developed more than thirty years ago, and since that time, the bacterium has learned to defend itself to become resistant to many of the current drugs. The great need for effective drugs has led researchers at the European Molecular Biology Laboratory (EMBL) Hamburg Outstation and a mix of academic and industrial collaborators to study the proteins in the bacterium, which are the functional machines behind the tuberculosis. By studying the structures of these proteins, an approach termed 'structural proteomics', they hope to find more effective drugs against Mtb.

In support of their efforts, the German Federal Ministry of Education and Research has now awarded a 3.5 million Euro grant as part of the government's proteomics initiative "New efficient procedures for functional proteome analysis". The project will be coordinated by EMBL Hamburg and comprises three additional academic partners (Max-Planck Groups for Molecular Structural Biology, Hamburg; Max-Planck-Institute for Infectious Biology, Berlin; Technical University of Munich, Research Center Weihenstefan) and three industrial partners (Biomax, Martinsried; Combinature, Berlin; MarResearch, Norderstedt).

EMBL Hamburg and their partners will work together to apply a step-by-step, structure-based approach to this drug discovery oriented process. In a novel approach, the Max-Planck-Institute for Infectious Biology, Berlin, will analyse the expression of Mtb

Contact: Trista Dawson
European Molecular Biology Laboratory

Page: 1 2 3

Related biology news :

1. Fighting fire with fire? Vaccine based on chimp virus shows promise against HIV
2. Fighting the spread of sudden oak death
3. Fighting the battle of the bulge in children
4. Fighting breast cancer at the molecular level
5. Fighting Fungi
6. Fighting skin cancers with computers and technology
7. Fighting diabetes: UD researchers move closer to chip-based control of smart, implantable insulin pumps
8. Trash From Crop-Processing Plant Harvested For Disease-Fighting Agents
9. Studies At Cedars-Sinai Confirm Identity Of An Elusive Receptor In Human Cells -- A Breakthrough In Understanding, Fighting Septic Shock
10. Chemical Contaminants May Inhibit Cancer-Fighting White Blood Cells
11. Radioactive Beads Latest Weapon In Fighting Cancer In Dogs, Cats

Post Your Comments:

(Date:1/29/2020)... RESEARCH TRIANGLE PARK, N.C. (PRWEB) , ... January ... ... as a partner to lead the new Analytics and Data Sciences practice, providing ... life sciences clients. Burke’s appointment was announced by Mike Townley, co-founder and Managing ...
(Date:1/27/2020)... ... January 27, 2020 , ... On Thursday, February 20, 2020 ... Sciences, Reed Tech and Richard Castle, Global Account Manager Medical Device at ... procedure, other topics include EU MDR timing deadlines, best practices in creating and submitting ...
(Date:1/23/2020)... ... 23, 2020 , ... GIOSTAR/HEAMGEN has developed and ... The red blood cells are made utilizing a bioreactor that permits the ... and replaces the need for a human blood donor. GIOSTAR/HEAMGEN mature ...
Breaking Biology News(10 mins):
(Date:1/24/2020)... , ... January 24, 2020 , ... The plastic and ... Surgery Center in New Jersey epitomize the notion that plastic surgery is much more ... characterized in popular media. , Over the last 20 years NJ Top Docs, Dr. ...
(Date:1/23/2020)... ... January 22, 2020 , ... Ideal ... cosmetic surgery industry at two recent North American investor forums specializing in medical ... Genuity Medical Technologies & Diagnostics Forum on November 21, 2019 in New York ...
(Date:1/22/2020)... DIEGO (PRWEB) , ... January 21, 2020 , ... ... to challenges with the precision of Genome editing. The partners have agreed to ... control (QC) of CRISPR research, agricultural, and pre-clinical programs. Over the longer-term, the ...
(Date:1/10/2020)... ... January 09, 2020 , ... Phlexglobal, the ... the acquisition of Cunesoft, a move that expands the company’s portfolio of best-of-breed ... sciences companies. , Based in Munich, Germany, Cunesoft provides intelligent software and expert ...
Breaking Biology Technology:
Cached News: