HOME >> BIOLOGY >> NEWS
Fighting diabetes: UD researchers move closer to chip-based control of 'smart,' implantable insulin pumps

injections, Parker says. In clinical trials, meanwhile, some 600 diabetic patients worldwide are using MiniMed Technologies' revolutionary implantable pump, which has not yet been approved by the U.S. Food and Drug Administration (FDA).

Compared to frequent insulin injections, Doyle says, pumps seem to provide patients with improved control of their blood-sugar levels, so that they're less vulnerable to diabetes-related health problems.

Smart pumps on the horizon?

But, existing implantable designs simply deliver a low dose of insulin on a continuous basis, Parker notes. Patients also can self-administer additional insulin before a meal.

"By developing glucose sensors and predictive algorithms for these devices," Parker says, "we hope to dramatically improve and automate the control of blood-sugar levels."

Highly precise control is important because sugar concentrations above the normal level of 70 to 120 milligrams of glucose per deciliter of blood (mg/dl) have been associated with liver damage, blindness and other medical problems. And, cells begin to starve when blood-sugar levels fall too low.

So, UD researchers are working on "a smarter brain for the next generation of implantable insulin pumps," Doyle says. "In the future, our system could fit on a computer chip, processing glucose sensor information, and then translating that data into pump action."

Predicting the body's insulin needs

Traditionally, mathematical commands or algorithms for controlling blood-sugar levels have been "like a thermostat-either on or off," Doyle says. "The classic approach has been a bang-bang type of algorithm," he added. "When sugar levels are high, these systems deliver a dose of insulin. When sugar is low, they turn insulin delivery back down."

Unfortunately, this approach isn't "meal-proof," Doyle says, and it doesn't reflect dramatic variations among individuals. In other words, "These algorithms can't predict and plan ahead for the increase
'"/>

Contact: Ginger Pinholster
gingpin@udel.edu
302-831-6408
University of Delaware
6-Jun-1999


Page: 1 2 3

Related biology news :

1. Fighting Mycobacterium tuberculosis with structural proteomics
2. Fighting fire with fire? Vaccine based on chimp virus shows promise against HIV
3. Fighting the spread of sudden oak death
4. Fighting the battle of the bulge in children
5. Fighting breast cancer at the molecular level
6. Fighting Fungi
7. Fighting skin cancers with computers and technology
8. Trash From Crop-Processing Plant Harvested For Disease-Fighting Agents
9. Studies At Cedars-Sinai Confirm Identity Of An Elusive Receptor In Human Cells -- A Breakthrough In Understanding, Fighting Septic Shock
10. Chemical Contaminants May Inhibit Cancer-Fighting White Blood Cells
11. Radioactive Beads Latest Weapon In Fighting Cancer In Dogs, Cats

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... -- A new partnership announced today will help life ... a fraction of the time it takes today, ... insurance policies to consumers without requiring inconvenient and ... rapid testing (A1C, Cotinine and HIV) and higi,s ... pulse, BMI, and activity data) available at local ...
(Date:4/13/2016)... 13, 2016  IMPOWER physicians supporting Medicaid patients in ... new clinical standard in telehealth thanks to a new ... higi platform, IMPOWER patients can routinely track key health ... mass index, and, when they opt in, share them ... to a local retail location at no cost. By ...
(Date:3/29/2016)... , March 29, 2016 LegacyXChange, ... LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased to announce ... used in a variety of writing instruments, ensuring athletes ... originally created collectibles from athletes on LegacyXChange will be ... of the DNA. Bill Bollander , ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
(Date:6/23/2016)... MONICA, Calif. , June 23, 2016  The Prostate Cancer Foundation ... pioneer increasingly precise treatments and faster cures for prostate cancer. Members of the ... institutions across 15 countries. Read More About the Class ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... launch of the Supplyframe Design Lab . Located in Pasadena, Calif., the ... future of how hardware projects are designed, built and brought to market. , ...
(Date:6/23/2016)... Ky. , June 23, 2016 ... two Phase 1 clinical trials of its complement ... placebo-controlled, single and multiple ascending dose studies designed ... pharmacodynamics (PD) of subcutaneous injection in healthy adult ... subcutaneously (SC) either as a single dose (ranging ...
Breaking Biology Technology:
Cached News: