HOME >> BIOLOGY >> NEWS
Finding Reveals Broader Role Of Telomerase Enzyme, Suggesting New Target For Extending Life Span Of Cell

Researchers at UC San Francisco have determined that telomerase - the enzyme brought to fame last year when scientists demonstrated that its insertion into normal cells extended the healthy life span of the cells indefinitely - can wield its power in an unexpected way.

The finding, reported in the current issue of Proceedings of the National Academy of Sciences, could bolster efforts aimed at manipulating the enzyme for therapeutic purposes - whether to prompt cell division in order to replenish stocks of healthy cells, as is needed in bone marrow transplants, or to interrupt the excessive cell proliferation that occurs in cancer cells.

Telomerase synthesizes telomeres, snippets of DNA on the ends of chromosomes that function in part like the plastic tips on the ends of shoelaces, preventing the gene-bearing, threadlike spindles from unraveling. With each cycle of cell division, the tips of telomeres drop off, until the chemical bookends become so eroded that the chromosomes become unstable, a condition that signals cells to stop dividing. This natural control on cell division is known as the Hayflick limit. Cancers develop when cells increasingly ignore or override such signals of chromosome impairment.

Until now, evidence has suggested that the ability of telomerase to extend the life span of cells lay in its capacity to lengthen telomeres.

In the current study, a collaboration by the laboratories of Elizabeth Blackburn, PhD, chair of the Department of Microbiology and Immunology at UCSF and Nobel laureate J. Michael Bishop, MD, chancellor of UCSF, researchers have determined that telomerase can extend the life span of human fibroblast cells without lengthening telomeres. The telomerase enzyme, they discovered, caps the ends of telomeres and, in so doing, somehow contributes to telomere, and thus, chromosome, stability - regardless of telomere length.

"The finding was quite extraordinary," said Blackburn. "Previous evidence has sugges
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
2-Apr-1999


Page: 1 2 3 4

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Finding the hole in the defenses of cavity-creating microbes
3. Findings redefine mechanism of action of RNA helicase enzymes
4. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
5. Finding may help eczema sufferers tolerate smallpox vaccine
6. Findings could aid efforts to harness nature for making drugs
7. Findings offer clue to how molecule can both stimulate, suppress cell growth
8. Findings offer further understanding about growth and development in young male gymnasts
9. Findings in frog oocytes may help study of chromosome physiology
10. Finding dirty bombs and other radiation threats
11. Finding life away from Earth will be tough task, says noted paleontologist

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... ... , ... In an upcoming episode scheduled for the fall of 2020, Advancements ... (POCT). Check local listings for more info. , Today, the majority of testing is ... labs throughout the country. Results are then available several days later. Now, in an ...
(Date:6/23/2020)... (PRWEB) , ... June 23, ... ... provider of gene-to-protein and monoclonal antibody development services, today announced that the ... products and services to the pharmaceutical, diagnostics, and research industries. The decision ...
(Date:6/23/2020)... ... 2020 , ... The field of quantitation of large molecules or proteins has ... area. However, the use of mass spectrometry in this field has gained a lot ... do you choose which approach to use (LBA or MS)?” In many cases, ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 12, 2020 , ... Inc. magazine today revealed that ... FDA compliance consulting has been named on its annual Inc. 5000 list, the ... unique look at the most successful companies within the American economy’s most dynamic ...
(Date:8/3/2020)... , ... August 03, 2020 , ... Introducing Ardent Animal ... transformative growth, , Known as MediVet Biologics since its formation ... The new Ardent Animal Health will build on its base of innovative ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and ... can drive one or two switches in a push-pull configuration; yielding fast fall ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted ... will cover the history of eSource, the reasons it did not take off as ... to site source, the industry is moving towards capturing data electronically for clinical trials ...
Breaking Biology Technology:
Cached News: