HOME >> BIOLOGY >> NEWS
Finding may help eczema sufferers tolerate smallpox vaccine

SAN DIEGO - The lack of a certain peptide in the skin of people with atopic dermatitis--the most common form of eczema--may explain why they are at high risk of adverse reactions to the smallpox vaccine, report scientists in the February Journal of Immunology. The finding may lead to new treatments to allow those with the skin condition to be vaccinated against smallpox without breaking out in a potentially deadly rash.

According to co-investigator Richard L. Gallo, MD, PhD, a dermatologist at the Veterans Affairs (VA) San Diego Health Care System and the University of California, San Diego, the finding may also lead to safer testing to identify those who should not receive the vaccine.

"Understanding the role of natural human antibiotics in diseases such as atopic dermatitis gives us a window into the possible reasons behind susceptibility to infections, and may help us better predict and control reactions to the smallpox vaccine or similar agents," said Gallo.

Gallo collaborated with a team at the National Jewish Medical and Research Center and Colorado Health Sciences Center that included lead investigator Michael D. Howell, PhD, and senior author Donald Y. M. Leung, MD, PhD.

In experiments in test tubes and mice, the researchers found that a germ-killing peptide called LL-37--largely absent from the skin of those with atopic dermatitis--selectively kills vaccinia, the living virus in the smallpox vaccine. The virus is a relatively benign cousin of variola, the virus in smallpox. The researchers believe LL-37 may be a key part of the normal immune response that allows vaccinia to confer immunity for smallpox but stops it before it can replicate and cause harm.

In 2002, a team including Gallo and Leung reported that people with atopic dermatitis (AD) are prone to recurring skin infections because they fail to produce germ-killing peptides known as beta-defensins and cathelicidins. These include "antimicrobial cathelicid
'"/>

Contact: Cindy Butler
cynthia.butler@med.va.gov
858-552-4373
VA Research Communications Service
30-Jan-2004


Page: 1 2 3

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Finding the hole in the defenses of cavity-creating microbes
3. Findings redefine mechanism of action of RNA helicase enzymes
4. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
5. Findings could aid efforts to harness nature for making drugs
6. Findings offer clue to how molecule can both stimulate, suppress cell growth
7. Findings offer further understanding about growth and development in young male gymnasts
8. Findings in frog oocytes may help study of chromosome physiology
9. Finding dirty bombs and other radiation threats
10. Finding life away from Earth will be tough task, says noted paleontologist
11. Finding a Holy Grail: simulated and experimental protein folding compares nicely

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2019)... ... June 13, 2019 , ... KICVentures announced today its plans to ... and Pain Management-Driven ASC Conference in Chicago on Thursday, June 13th at 6:30 pm. ... Chicago, IL in the 3rd floor Ticino Hospitality room in space #74T. , The ...
(Date:6/6/2019)... ... June 05, 2019 , ... MedTech ... the global health and medical technology market, announced that it has selected Medacta ... Robotics Solution” award in the 2019 MedTech Breakthrough Awards program. , ...
(Date:6/4/2019)... ... June 04, 2019 , ... Molecular Devices, a global leader ... the new President of Molecular Devices, replacing Greg Milosevich who has been appointed ... , Since joining Molecular Devices in a scientific engineering role, Ms. Murphy has ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 29, 2019 , ... For many years, the primary ... of cancer demand breakthrough therapies. Advances in immuno-oncology have led to the advent of ... cells with engineered T cell receptors known as “CARs”. The CAR enables the final ...
(Date:5/22/2019)... ... 22, 2019 , ... Artemis (formerly Agrilyst), the leading enterprise Cultivation ... round co-led by Astanor Ventures and Talis Capital with participation ... iSelect Fund . The company has raised $11.75m to date and will use the ...
(Date:5/14/2019)... Calif. (PRWEB) , ... May 14, 2019 , ... ... office expansion, effectively doubling its space from 2,500 to 5,000 square feet. , ... Early Gender DNA tests ,” says Gateway Genomics CEO, Chris Jacob. “The SneakPeek At-Home ...
(Date:5/2/2019)... BELTSVILLE, Md. (PRWEB) , ... ... ... certification to the International Organization for Standardization ISO 9001:2015 standard, REPROCELL USA ... consistently meet customer requirements. In addition, REPROCELL USA Inc. aims to enhance ...
Breaking Biology Technology:
Cached News: