HOME >> BIOLOGY >> NEWS
Finding suggests a common childhood leukemia may form in the womb

Researchers led by a scientist who joined the UC San Francisco faculty last week are reporting that a genetic mutation implicated in a common form of childhood leukemia appears to occur in the womb.

Their study, reported in the Oct. 30 issue of Lancet, indicates that two genes, known as TEL and AML1, aberrantly fuse during the development of the blood cells in the fetus. The fused genes then produce a protein that is potentially oncogenic.

Based on previous research, the team says the fused state of the two genes is not inherited; instead, it occurs during pregnancy, probably as a result of a developmental accident, as opposed to exposure to an environmental mutagen.

Importantly, the fusion of the TEL and AML1 genes is not sufficient to cause development of the disease, known as "common acute lymphoblastic leukemia," the researchers said. All people have two copies of every gene, and earlier work by the researchers on identical twins with leukemia indicates that a second genetic alteration - involving the second copy of the TEL gene, one of the two so-called "alleles" -- occurs post-natally to actually nudge blood cells into a leukemic state.

"It may be that the normal TEL allele successfully suppresses the function of the aberrant TEL-AML1 protein resulting from the fusion, so full-blown leukemia doesn't occur," said the lead author of the study, Joseph Wiemels, PhD, now a UCSF assistant research molecular epidemiologist. "One theory is that the second, normal TEL allele is lost, and that at this point the fused TEL-AML1 protein becomes oncogenic."

The researchers don't know what leads to the initial genetic abnormality in the womb, but their discovery, said Wiemels, will provide researchers with a time frame for analyzing the development of the mutation. Studies indicate that the second genetic alteration may result from an abnormal reaction to common childhood infections.

Wiemels conducted the research in the laboratory of Mel Greave
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
1-Nov-1999


Page: 1 2 3

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Finding the hole in the defenses of cavity-creating microbes
3. Findings redefine mechanism of action of RNA helicase enzymes
4. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
5. Finding may help eczema sufferers tolerate smallpox vaccine
6. Findings could aid efforts to harness nature for making drugs
7. Findings offer clue to how molecule can both stimulate, suppress cell growth
8. Findings offer further understanding about growth and development in young male gymnasts
9. Findings in frog oocytes may help study of chromosome physiology
10. Finding dirty bombs and other radiation threats
11. Finding life away from Earth will be tough task, says noted paleontologist

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Finding suggests common childhood leukemia may form the womb

(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ... of the "iPhone 5S Fingerprint Sensor - ... report to their offering. ... of AuthenTec in July 2012, Apple introduced the ... is currently the only device of Apple incorporating ...
(Date:12/19/2014)... Dec. 18, 2014   LaunchKey , the first ... post-password and Internet of Things era, today announced the ... venture round was led by Metamorphic Ventures with participation ... Partners, VegasTechFund, and others.  LaunchKey has raised $4 million ... expand its team and bring LaunchKey to market in ...
(Date:12/17/2014)... 15, 2014  HITLAB SM announced today ... audit to confirm its adherence to current U.S. ... enables HITLAB to conduct regulated smart device and ... for patient safety and research quality. ... quality, and delivery with innovative technology," said ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
(Date:12/19/2014)... (PRWEB) December 19, 2014 In contrast ... of LEDs with various colors, Valoya uses proprietary LED ... This offers best possible uniformity which is critical in ... and high spectral accuracy throughout its lifetime which is ... LED tubes. , "The investment cost was clearly ...
(Date:12/19/2014)... 18, 2014  Decision Resources Group finds that the ... will grow moderately through 2023 as the aging population, ... of dental biomaterials all spur procedure volumes. Growth will ... China and India ... within reach for a larger proportion of the population. ...
(Date:12/19/2014)... 18, 2014 Relmada Therapeutics, Inc. (OTCQB: RLMD), ... of chronic pain, announced the results of its annual ... was a transformational year in Relmada,s history and it ... company," said Sergio Traversa , chief executive officer ... on key financial, human resource and clinical development objectives ...
(Date:12/17/2014)... “Never say, ‘I cannot do ... Department of Physics, advises young women pursuing careers ... SPIE Women in Optics 18-month planner ... ask questions.” , In the annual planner, women ... ranging from university professor and laboratory researcher to ...
Breaking Biology Technology:Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3
Cached News: