HOME >> BIOLOGY >> NEWS
Findings aid understanding of neurodegenerative diseases

EVANSTON, Ill. -- Northwestern University scientists have made a key molecular discovery that has implications for a wide range of diseases characterized by the loss of nerve function, including Huntington's, Parkinson's, Alzheimer's and Lou Gehrig's diseases, cystic fibrosis and Creutzfeldt-Jakob disease, the human form of mad cow disease.

The findings, which will be published in the Oct. 1 issue of Nature Cell Biology, could lead to an understanding of how to prevent these diseases and to the development of effective drugs.

All human neurodegenerative diseases have two things in common. First, misfolded and damaged proteins clump together to form toxic species that aggregate, destroy cell function and cause disease. Second, studies have shown that special protective proteins, called molecular chaperones, can suppress these toxic effects. This question remained: How do the chaperones and aggregates interact with each other?

A research team led by Richard I. Morimoto, John Evans Professor of Biology, now can answer that question. The researchers have become the first to view, in living cells and in real time, the interactions between the beneficial molecular chaperone Hsp70 and the damaging protein aggregate, shedding light on how the chaperone works to minimize aggregate growth.

"We now understand how the chaperone influences the aggregate's toxic effect on the cell," said Morimoto. "We observed that the chaperone is binding to and then coming off the aggregate all the time. This dynamic relationship is unusual because the aggregate, the result of a genetic mutation, brings healthy and otherwise normal proteins to aggregate irreversibly with them. But this clearly is not the case with the molecular chaperone."

Instead, the molecular chaperone is allowed, for reasons not fully understood, to do its work preventing healthy proteins essential to cell function from being bound to the aggregate, a biochemical "black hole."
'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
29-Sep-2002


Page: 1 2 3

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Findings redefine mechanism of action of RNA helicase enzymes
3. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
4. Findings could aid efforts to harness nature for making drugs
5. Findings offer clue to how molecule can both stimulate, suppress cell growth
6. Findings offer further understanding about growth and development in young male gymnasts
7. Findings in frog oocytes may help study of chromosome physiology
8. Findings show exceptional longevity runs in families
9. Findings give insight into how colon cells transform into precancerous polyps
10. Findings conclude sustained caffeine intake negates the benefits of creatine supplements
11. Findings link disease specific anitbodies to activation of T cells for the first time

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/5/2019)... (PRWEB) , ... March 05, 2019 , ... Join this ... how a metadata-driven approach will help data analysts and bioinformaticians focus on data analysis ... unify data that can come from different source systems. Some sources of data include:, ...
(Date:2/27/2019)... ... ... Circulomics is launching the Short Read Eliminator Kit to perform ... , This kit enhances long-read sequencing read lengths by using size selective precipitation ... and recovered with high efficiency. Short DNA up to 25 kb in length are ...
(Date:2/22/2019)... ... 2019 , ... Clean label food is not just another passing trend in ... It is quite common to spot consumers running their index finger across the back ... this label scrutiny. , More than ever, meat and poultry producers are working ...
Breaking Biology News(10 mins):
(Date:3/14/2019)... ... 14, 2019 , ... ON NOVEMBER 27, 2018, Nova Oculus ... Machine Canada Inc., had been given approval to begin a clinical patient trial ... (AMD). , The previous month, the medical devices bureau of Health Canada had ...
(Date:3/14/2019)... ... March 14, 2019 , ... ... standard solution for preclinical research organizations. It is a low code, GDPR/21 ... systems and facilities, innovative technology-driven automated data capture and seamless data and ...
(Date:3/11/2019)... ... March 11, 2019 , ... In this live webinar, the featured speakers will ... efficiency and experience. Participants will learn how to use the information they have from ... the simple or complex randomization scheme is properly designed and set up to ensure ...
(Date:3/9/2019)... ... March 08, 2019 , ... ... announced the release of their Best Online Master's in Biotechnology Programs for ... curriculum quality, program flexibility, affordability, and graduate outcomes. , In addition to ...
Breaking Biology Technology:
Cached News: