HOME >> BIOLOGY >> NEWS
Findings could aid efforts to harness nature for making drugs

WEST LAFAYETTE, Ind. - Chemical engineers at Purdue University have shown how to make yeast cells double the activity and boost productivity of a type of enzyme plants need to create important chemicals such as anticancer compounds.

The work is related to efforts aimed at developing techniques to use plants and microorganisms as natural factories for producing pharmaceuticals. Such techniques would be safer and more environmentally friendly than conventional methods for making drugs, which often require hazardous chemicals and steel "reactors" operated at high pressures and temperatures. The enzymes from plants and other organisms typically function in water near room temperature under ordinary pressure.

The Purdue researchers demonstrated that altering the nutrients and carefully controlling fermentation time caused yeast cultures to produce an enzyme called ferulate 5-hydroxylase that has twice its normal rate of activity, which increases the enzyme's productivity.

"Activity relates to the amount of product that can be synthesized in a given time," said John Morgan, an assistant professor of chemical engineering at Purdue. "So we could make more than twice the amount of product per hour."

Findings are detailed in a paper appearing in the Jan. 20 issue of the journal Biotechnology and Bioengineering, published by John Wiley & Sons Inc. The paper was written by Morgan and Purdue doctoral student Hanxiao Jiang.

The enzyme is a member of a family of enzymes called cytochrome P450, which plants need to produce numerous chemical compounds.

Plants ordinarily produce small quantities of "flavonoids," which are beneficial chemicals known as antioxidants. So researchers are developing ways to boost production of the chemicals by transferring vital enzymes from plants to microorganisms. Because P450 enzymes are "biocatalysts" that enable an organism to produce the beneficial drugs, researchers are trying to develop techniques t
'"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
28-Jan-2004


Page: 1 2 3

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Findings redefine mechanism of action of RNA helicase enzymes
3. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
4. Findings offer clue to how molecule can both stimulate, suppress cell growth
5. Findings offer further understanding about growth and development in young male gymnasts
6. Findings in frog oocytes may help study of chromosome physiology
7. Findings aid understanding of neurodegenerative diseases
8. Findings show exceptional longevity runs in families
9. Findings give insight into how colon cells transform into precancerous polyps
10. Findings conclude sustained caffeine intake negates the benefits of creatine supplements
11. Findings link disease specific anitbodies to activation of T cells for the first time

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/2/2019)... ... May 01, 2019 , ... uBiome, the ... John Rakow, the Company’s General Counsel, as Interim Chief Executive Officer of uBiome, ... currently on administrative leave. There will also be an independent investigation into uBiome’s ...
(Date:4/25/2019)... ... April 23, 2019 , ... ... testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is ... in Egg Harbor Township, New Jersey. The new facility was custom designed to ...
(Date:4/25/2019)... ... April 24, 2019 , ... NDA Partners Chairman Carl Peck, MD , ... experience in the development of drug and genomic diagnostic products for therapeutic indications in ... NDA Partners, Dr. Maddala served as Vice President of Biometrics at GRAIL, Inc., where ...
Breaking Biology News(10 mins):
(Date:5/2/2019)... S.D. (PRWEB) , ... April 30, 2019 , ... The ... from industrial scale macro breweries to local craft breweries, and even home brewing clubs ... very complex chemical and biological processes, that when mastered can produce a superb product. ...
(Date:5/2/2019)... (PRWEB) , ... May 02, 2019 , ... ... genetics testing company, will present results documenting discrepancies between U.S. insurer policies for ... for patients at risk for hereditary breast and ovarian cancer (HBOC). ...
(Date:4/25/2019)... , ... April 23, 2019 , ... Frank is an albino, deaf Great Dane. His ... want him due to his health issues. Despite his hearing impairment, he was always an ... the two would play all day, every day. As the two grew, playtime became rougher ...
(Date:4/18/2019)... (PRWEB) , ... April 18, 2019 , ... ... fuels, a research team that includes a chemical engineer at Worcester Polytechnic Institute ... microorganism that may make it possible to manufacture isobutanol and other biofuels more ...
Breaking Biology Technology:
Cached News: