HOME >> BIOLOGY >> NEWS
Findings could aid efforts to harness nature for making drugs

hat cause plants to make greater quantities of the enzymes and enzymes that are more productive.

The method pursued by the Purdue researchers was to focus on a gene responsible for producing ferulate 5-hydroxylase.

Altering the composition of nutrients fed to the yeast cultures and controlling the fermentation time caused the gene to be "expressed," producing 45 percent more of the enzyme while doubling the enzyme's activity.

Increasing the quantity and activity of various cytochrome P450 enzymes might enable scientists to use plants and microorganisms like E. coli and baker's yeast to one day commercially produce pharmaceuticals. More progress is needed, however, before it will be practical to use plants and plant enzymes in microorganisms as natural pharmaceutical factories, Morgan said.

"I wouldn't consider this a major breakthrough, but it does represent significant progress in improving the expression of the enzyme," he said. "I think there is certainly room for greater expression of these P450 enzymes."

The same technique could be used to increase the production of other P450 enzymes, Morgan said.

"The plant kingdom contains a large and relatively untapped diversity of P450s that are needed to create thousands of valuable natural products," he said.

In ongoing work, the Purdue researchers also are trying to develop methods for coaxing the enzymes to make drugs not normally produced by plants.

"We are feeding them what's known as substrate analogs, or compounds that are structurally similar to the compound that this enzyme will normally recognize and react with but are somewhat structurally different," Morgan said. "Therefore, if the enzyme recognizes this compound, it will produce a novel product, or a product that's never been synthesized before.

"From a scientific standpoint, we want to better understand precisely how organisms make certain compounds, and from an engineering standpoint,
'"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
28-Jan-2004


Page: 1 2 3

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Findings redefine mechanism of action of RNA helicase enzymes
3. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
4. Findings offer clue to how molecule can both stimulate, suppress cell growth
5. Findings offer further understanding about growth and development in young male gymnasts
6. Findings in frog oocytes may help study of chromosome physiology
7. Findings aid understanding of neurodegenerative diseases
8. Findings show exceptional longevity runs in families
9. Findings give insight into how colon cells transform into precancerous polyps
10. Findings conclude sustained caffeine intake negates the benefits of creatine supplements
11. Findings link disease specific anitbodies to activation of T cells for the first time

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
(Date:4/18/2017)... Inc., a global expert in SoC-based imaging and computing solutions, has ... features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® ... be showcased during the upcoming Medtec Japan at Tokyo Big Sight ... Las Vegas Convention Center April 24-27. ... Click here for an image of the ...
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market ... Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast ... from USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... September 19, 2017 , ... ... (NYS DFS) cybersecurity regulations have transitioned into full force and effect. ... in the state (“Covered Entities”) to conduct an annual, professional, comprehensive cybersecurity ...
(Date:9/18/2017)... ... 2017 , ... Transportable biomass conversion facilities and the economics ... the topic of a September 27 webinar hosted by the Waste ... biomass conversion facilities for producing biochar, briquettes, and torrefied wood, biomass supply chains ...
(Date:9/18/2017)... Montrium , a growing leader in Electronic Trial Master file ... non-profit research organization, Multidisciplinary Association for Psychedelic Studies (MAPS). ... MAPS Public Benefit Corporation ... ... MDMA for the treatment of Posttraumatic Stress Disorder (PTSD). MAPS also ...
(Date:9/17/2017)... ... September 17, 2017 , ... ... South Korean Ministry of Food and Drug Safety (KMFDS) for an Investigational New ... the Middle East Respiratory Syndrome coronavirus (MERS-CoV). The study in Korea represents the ...
Breaking Biology Technology:
Cached News: