HOME >> BIOLOGY >> NEWS
Findings could aid efforts to harness nature for making drugs

hat cause plants to make greater quantities of the enzymes and enzymes that are more productive.

The method pursued by the Purdue researchers was to focus on a gene responsible for producing ferulate 5-hydroxylase.

Altering the composition of nutrients fed to the yeast cultures and controlling the fermentation time caused the gene to be "expressed," producing 45 percent more of the enzyme while doubling the enzyme's activity.

Increasing the quantity and activity of various cytochrome P450 enzymes might enable scientists to use plants and microorganisms like E. coli and baker's yeast to one day commercially produce pharmaceuticals. More progress is needed, however, before it will be practical to use plants and plant enzymes in microorganisms as natural pharmaceutical factories, Morgan said.

"I wouldn't consider this a major breakthrough, but it does represent significant progress in improving the expression of the enzyme," he said. "I think there is certainly room for greater expression of these P450 enzymes."

The same technique could be used to increase the production of other P450 enzymes, Morgan said.

"The plant kingdom contains a large and relatively untapped diversity of P450s that are needed to create thousands of valuable natural products," he said.

In ongoing work, the Purdue researchers also are trying to develop methods for coaxing the enzymes to make drugs not normally produced by plants.

"We are feeding them what's known as substrate analogs, or compounds that are structurally similar to the compound that this enzyme will normally recognize and react with but are somewhat structurally different," Morgan said. "Therefore, if the enzyme recognizes this compound, it will produce a novel product, or a product that's never been synthesized before.

"From a scientific standpoint, we want to better understand precisely how organisms make certain compounds, and from an engineering standpoint,
'"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
28-Jan-2004


Page: 1 2 3

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Findings redefine mechanism of action of RNA helicase enzymes
3. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
4. Findings offer clue to how molecule can both stimulate, suppress cell growth
5. Findings offer further understanding about growth and development in young male gymnasts
6. Findings in frog oocytes may help study of chromosome physiology
7. Findings aid understanding of neurodegenerative diseases
8. Findings show exceptional longevity runs in families
9. Findings give insight into how colon cells transform into precancerous polyps
10. Findings conclude sustained caffeine intake negates the benefits of creatine supplements
11. Findings link disease specific anitbodies to activation of T cells for the first time

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Findings could aid efforts harness nature for making drugs

(Date:3/26/2015)... , March 26, 2015 ... family, social, recreation and athletic club, today announced it ... to allow freedom of movement for members and staff, ... "Following a comprehensive process, we selected FST,s IMID Access ... and convenience for our members and staff, in addition ...
(Date:3/24/2015)... 2015   NexID Biometrics LLC, whose spoof-mitigation ... today announced the beginning of shipments of version 2.0 ... The company, based in Potsdam, N.Y. ... Expo, which began here today at the Walter E. ... of its SDK boosts the accuracy rate range to ...
(Date:3/23/2015)... NEW YORK , March 23, 2015   ... digital property management company, today announced that the Company ... platform for both enterprise and consumers at Connect:ID on ... D.C. HOYOS Labs will highlight the IEEE ... 1U TM ; and enterprise access control system. ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
(Date:3/27/2015)... (PRWEB) March 27, 2015 The consumption ... back of the recession and high prices in 2008. ... has recovered and keeps on gaining momentum now. , ... stands at more than 100,000 thousand tonnes. No considerable ... Meantime, the global capacity rocketed during 2012-2013, registering 11% ...
(Date:3/27/2015)... , March 27, 2015   SurePure, ... liquid photopurification, announced today that the Company has ... the continued trading of SurePure ("SURP") securities on ... marketplace for entrepreneurial and development stage companies. ... introduced standards and eligibility requirements designed to improve ...
(Date:3/27/2015)... March 27, 2015 WuXi PharmaTech (Cayman) ... R&D capability and technology platform company serving the ... today that an Investigational New Drug (IND) application ... rheumatoid arthritis has been accepted for review by ... In September 2012, MedImmune, the global ...
(Date:3/26/2015)... March 26, 2015  Roka Bioscience, Inc. (NASDAQ: ... on providing advanced testing solutions for the detection ... for the three months and full year ended ... Financial Results:Revenue for the quarter ended December 31, ... the fourth quarter of 2013 and $1.5 million ...
Breaking Biology Technology:World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 3SurePure Completes Verification and Approved for Trading on the OTCQB Marketplace 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 2Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 6Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 7
Cached News: