HOME >> BIOLOGY >> NEWS
Findings could aid efforts to harness nature for making drugs

hat cause plants to make greater quantities of the enzymes and enzymes that are more productive.

The method pursued by the Purdue researchers was to focus on a gene responsible for producing ferulate 5-hydroxylase.

Altering the composition of nutrients fed to the yeast cultures and controlling the fermentation time caused the gene to be "expressed," producing 45 percent more of the enzyme while doubling the enzyme's activity.

Increasing the quantity and activity of various cytochrome P450 enzymes might enable scientists to use plants and microorganisms like E. coli and baker's yeast to one day commercially produce pharmaceuticals. More progress is needed, however, before it will be practical to use plants and plant enzymes in microorganisms as natural pharmaceutical factories, Morgan said.

"I wouldn't consider this a major breakthrough, but it does represent significant progress in improving the expression of the enzyme," he said. "I think there is certainly room for greater expression of these P450 enzymes."

The same technique could be used to increase the production of other P450 enzymes, Morgan said.

"The plant kingdom contains a large and relatively untapped diversity of P450s that are needed to create thousands of valuable natural products," he said.

In ongoing work, the Purdue researchers also are trying to develop methods for coaxing the enzymes to make drugs not normally produced by plants.

"We are feeding them what's known as substrate analogs, or compounds that are structurally similar to the compound that this enzyme will normally recognize and react with but are somewhat structurally different," Morgan said. "Therefore, if the enzyme recognizes this compound, it will produce a novel product, or a product that's never been synthesized before.

"From a scientific standpoint, we want to better understand precisely how organisms make certain compounds, and from an engineering standpoint,
'"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
28-Jan-2004


Page: 1 2 3

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Findings redefine mechanism of action of RNA helicase enzymes
3. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
4. Findings offer clue to how molecule can both stimulate, suppress cell growth
5. Findings offer further understanding about growth and development in young male gymnasts
6. Findings in frog oocytes may help study of chromosome physiology
7. Findings aid understanding of neurodegenerative diseases
8. Findings show exceptional longevity runs in families
9. Findings give insight into how colon cells transform into precancerous polyps
10. Findings conclude sustained caffeine intake negates the benefits of creatine supplements
11. Findings link disease specific anitbodies to activation of T cells for the first time

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Findings could aid efforts harness nature for making drugs

(Date:6/24/2015)... Switzerland , June 24, 2015 ... partnership with emerging biometric password solution one face ... one face in, entering ... a ground-breaking and affordable multifactor-authentication biometric answer to ... recognition technology, provided in partnership with KeyLemon, one ...
(Date:6/23/2015)... , June 22, 2015 ... the addition of the "Body-Worn Temperature Sensors ... Trends and Forecast 2014 - 2020" report ... strategic analysis of the global body-worn temperature sensors ... been segmented on the basis of types, care ...
(Date:6/23/2015)... Fla. , June 23, 2015 /PRNewswire/ ... management and authentication solutions, today announced enhanced functionality ... multi-factor authentication solution.  The enhancements build on ... of the DigitalPersona Altus platform and provide ... compatibility. In today,s environment of ...
Breaking Biology News(10 mins):KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2
(Date:6/30/2015)... -- Juniper Pharmaceuticals, Inc. (Nasdaq: JNP ), a specialty ... unmet medical needs in women,s health, today announced ... at the Cantor Fitzgerald Inaugural Healthcare Conference as ... PM EDTLocation: , Le Parker Meridien Hotel, New ... under  ,Investor, or  click here The ...
(Date:6/30/2015)... Francisco, CA (PRWEB) , ... June 30, 2015 ... ... FMT Patients , Study will provide new insights on mechanics of fecal microbiota ... a new partnership to study the microbiome of patients undergoing fecal microbiota transplantation ...
(Date:6/30/2015)... ... June 30, 2015 , ... Noblis, Inc., a leading provider ... paper published this week in the scientific journal Viruses ( http://www.mdpi.com/1999-4915/7/6/2763 ), that ... used to detect the Ebola virus. Noblis worked with the Department of Defense’s ...
(Date:6/30/2015)... DENVER, CO (PRWEB) , ... June 30, 2015 , ... ... technologies, today announced that it has hired Gem Swartz to head up its account ... as senior account director. Both Gem and Amanda bring senior account management and delivery ...
Breaking Biology Technology:Juniper Pharmaceuticals to Present at Cantor Fitzgerald Inaugural Healthcare Conference on July 8, 2015 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 2Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 3Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 4Matrix Marketing Group Expands Client Services Team 2
Cached News: