HOME >> BIOLOGY >> NEWS
Findings give insight into how colon cells transform into precancerous polyps

A key signaling pathway appears to be critical to the earliest transformation of normal colon cells into growths called polyps that may advance to colon tumors, Vanderbilt-Ingram Cancer Center scientists have reported.

The findings suggest that, someday, doctors might use drugs that interrupt this pathway to treat individuals who are found to have colon cells on the verge of this transformation. The goal would be to prevent polyps -- and thus colon cancer -- from ever developing.

"Clearly, were a long way from doing that, but the prospects are very exciting," said Dr. Robert J. Coffey, Ingram Professor of Cancer Research and professor of Medicine and Cell Biology. Coffeys laboratory, in collaboration with the laboratory of David Threadgill, Ph.D., reported their findings recently in the Proceedings of the National Academy of Sciences.

The signalling pathway involves the epidermal growth factor receptor and the "ligands" that bind to it. The receptor sits across the cell surface, much like a satellite dish. The ligand fits into the receptor to transmit signals into the cell that prompt its growth. Scientists are focused on this pathway as more is learned about how it is involved in cancer development and progression and as new drugs are developed to interrupt it.

The Vanderbilt work helps clarify contradictory findings reported more than a year ago by two different groups. One group observed a 90 percent reduction in polyp formation when they used an inhibitor of EGFr in Min mice, a strain that is genetically engineered to develop hundreds of colon polyps. The other group did a similar experiment with a similar drug and found no effect.

So the Vanderbilt researchers instead turned to genetics. They took advantage of a mouse called waved2 that has a naturally occurring mutation in the EGFr tyrosine kinase domain (the section beneath the cell surface) that results in a 90 percent reduction in EGFr activity. These
'"/>

Contact: Cynthia Manley
cynthia.manley@mcmail.vanderbilt.edu
615-354-0936
Vanderbilt University Medical Center
19-Apr-2002


Page: 1 2

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Findings redefine mechanism of action of RNA helicase enzymes
3. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
4. Findings could aid efforts to harness nature for making drugs
5. Findings offer clue to how molecule can both stimulate, suppress cell growth
6. Findings offer further understanding about growth and development in young male gymnasts
7. Findings in frog oocytes may help study of chromosome physiology
8. Findings aid understanding of neurodegenerative diseases
9. Findings show exceptional longevity runs in families
10. Findings conclude sustained caffeine intake negates the benefits of creatine supplements
11. Findings link disease specific anitbodies to activation of T cells for the first time

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... Report on Form 10-K on Thursday April 13, 2017 with the ... The ... section of the Company,s website at http://www.nxt-id.com  under "SEC Filings," ... 2016 Year Highlights: Acquisition of ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... 19, 2017 , ... The new and improved Oakton® pocket testers, from Cole-Parmer, ... upright with a new cap design that is versatile, functional and leakproof. They are ... to test water quality. , The Oakton pocket testers have many user-friendly and functional ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... a partnership with Cytena GmbH to launch the CloneSelect™ Single-Cell Printer™ in North ... to isolate single cells and provide visual documentation of monoclonality for use in ...
(Date:9/18/2017)... ... September 18, 2017 , ... ... move of the SPIE Digital Library ( http://www.spiedigitallibrary.org ) on 15 August to ... an improved user experience and incorporate a number of enhancements and new features, ...
(Date:9/15/2017)... ... September 15, 2017 , ... ... it calls an ‘Internal Seed B’ round of financing, totaling $600,000. The ... completed using a ‘SAFE’ documentation structure at a company valuation of $10M. ...
Breaking Biology Technology:
Cached News: