HOME >> BIOLOGY >> NEWS
Findings give insight into how colon cells transform into precancerous polyps

A key signaling pathway appears to be critical to the earliest transformation of normal colon cells into growths called polyps that may advance to colon tumors, Vanderbilt-Ingram Cancer Center scientists have reported.

The findings suggest that, someday, doctors might use drugs that interrupt this pathway to treat individuals who are found to have colon cells on the verge of this transformation. The goal would be to prevent polyps -- and thus colon cancer -- from ever developing.

"Clearly, were a long way from doing that, but the prospects are very exciting," said Dr. Robert J. Coffey, Ingram Professor of Cancer Research and professor of Medicine and Cell Biology. Coffeys laboratory, in collaboration with the laboratory of David Threadgill, Ph.D., reported their findings recently in the Proceedings of the National Academy of Sciences.

The signalling pathway involves the epidermal growth factor receptor and the "ligands" that bind to it. The receptor sits across the cell surface, much like a satellite dish. The ligand fits into the receptor to transmit signals into the cell that prompt its growth. Scientists are focused on this pathway as more is learned about how it is involved in cancer development and progression and as new drugs are developed to interrupt it.

The Vanderbilt work helps clarify contradictory findings reported more than a year ago by two different groups. One group observed a 90 percent reduction in polyp formation when they used an inhibitor of EGFr in Min mice, a strain that is genetically engineered to develop hundreds of colon polyps. The other group did a similar experiment with a similar drug and found no effect.

So the Vanderbilt researchers instead turned to genetics. They took advantage of a mouse called waved2 that has a naturally occurring mutation in the EGFr tyrosine kinase domain (the section beneath the cell surface) that results in a 90 percent reduction in EGFr activity. These
'"/>

Contact: Cynthia Manley
cynthia.manley@mcmail.vanderbilt.edu
615-354-0936
Vanderbilt University Medical Center
19-Apr-2002


Page: 1 2

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Findings redefine mechanism of action of RNA helicase enzymes
3. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
4. Findings could aid efforts to harness nature for making drugs
5. Findings offer clue to how molecule can both stimulate, suppress cell growth
6. Findings offer further understanding about growth and development in young male gymnasts
7. Findings in frog oocytes may help study of chromosome physiology
8. Findings aid understanding of neurodegenerative diseases
9. Findings show exceptional longevity runs in families
10. Findings conclude sustained caffeine intake negates the benefits of creatine supplements
11. Findings link disease specific anitbodies to activation of T cells for the first time

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... Trends, opportunities and forecast in this market ... (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, vein ... use industry (government and law enforcement, commercial and retail, ... others), and by region ( North America ... Pacific , and the Rest of the World) ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... the prestigious international IAIR Award for the most innovative high security ePassport ... ... Maldives Immigration Controller General, Mr. ... on the right) have received the IAIR award for the "Most innovative ...
(Date:3/22/2017)... 2017   Neurotechnology , a provider of ... announced the release of the SentiVeillance 6.0 ... facial recognition using up to 10 surveillance, security ... The new version uses deep neural-network-based facial detection ... utilizes a Graphing Processing Unit (GPU) for enhanced ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... The AMA ... 11 high school graduates from across the nation. The scholarships are created through funds ... member dues. , Scholarship criteria are set by the AMA Scholarship Committee, which is ...
(Date:4/20/2017)... Ca (PRWEB) , ... April 20, 2017 , ... ... Virtual Event , this new webinar will explore challenging patient cases when screening ... to the hospital, there may be a need for bridging parental anticoagulation especially ...
(Date:4/20/2017)... SANTA BARBARA, CALIFORNIA (PRWEB) , ... April 20, 2017 , ... ... process optimization firm for the life sciences and healthcare industries, is pleased to announce ... of the new established USDM subsidiary “USDM Europe GmbH” based in Germany. , ...
(Date:4/20/2017)... LAVAL, QC , April 20, 2017 /PRNewswire/ - Prometic Life ... today presented new results at the International Liver Congress ("ILC") ... Liver ("EASL") in Amsterdam on the ... in a mouse model of obesity and metabolic syndrome. ... According to Dr. Lyne Gagnon, ...
Breaking Biology Technology:
Cached News: