HOME >> BIOLOGY >> NEWS
Findings link disease specific anitbodies to activation of T cells for the first time

Torrance, Calif. (January 25, 2002) - Harbor-UCLA Research & Education Institute (REI) announced new findings indicating that antibodies specific to Graves disease bind to cell surface receptors. These are distinct from thyroid-stimulating hormone (TSH) receptors. This interaction leads to activation of key genes and T cell activation. It is believed that antibody/receptor complex initiates a cascade of events culminating in T cell activities and thyroid growth. This research, conducted by principal REI investigator Terry J. Smith, MD and collaborators at Boston University School of Medicine, Boston was published recently in The Journal of Immunology, 168:942-950,2002.

What is exciting about these findings is that now, for the first time, we can tie together pathogenic antibodies in Graves disease with T cell activation, said Dr. Smith, Chief, Division of Molecular Medicine, Department of Medicine at Harbor-UCLA Medical Center. This holds promise for future research to learn how to turn off the expression, thereby eradicating the disease state. Graves disease is often associated with profound metabolic derangements and potentially site-threatening changes in the tissues around the eye, he added.

Dr. Smith and his collaborator, William Cruikshank, PhD at Boston University School of Medicine have been studying the pathogenesis of inflammation associated with many conditions, including rheumatoid arthritis, Graves disease, and lupus. This research group has recently identified a number of potential pathways that may be utilized by lymphocyte derived cytokines in driving the tissue remodeling that occurs in Graves disease. Dr. Smith and his associates have found that fibroblasts from the orbital connective tissue (eye area) differ from fibroblasts found in other parts of the body. The orbital fibroblasts appear to be particularly susceptible to inflammatory reactions. Fibroblasts are highly specialized cells and react differentl
'"/>

Contact: Barbara T. Kerr
bkerr@rei.edu
310-222-2820
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
24-Jan-2002


Page: 1 2

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Findings redefine mechanism of action of RNA helicase enzymes
3. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
4. Findings could aid efforts to harness nature for making drugs
5. Findings offer clue to how molecule can both stimulate, suppress cell growth
6. Findings offer further understanding about growth and development in young male gymnasts
7. Findings in frog oocytes may help study of chromosome physiology
8. Findings aid understanding of neurodegenerative diseases
9. Findings show exceptional longevity runs in families
10. Findings give insight into how colon cells transform into precancerous polyps
11. Findings conclude sustained caffeine intake negates the benefits of creatine supplements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2020)... (PRWEB) , ... June 11, 2020 , ... ... DNA services, announces a significant expansion of its forensic genealogy team. Bode’s ... and attorneys through proven forensic genealogy and DNA analysis methods. The team has ...
(Date:6/11/2020)... ... , ... Superior Controls, Inc. , an E Technologies Company and leading ... sciences industry, is pleased to announce the recent hiring of Ray Boudreau, who will ... Hampshire office. In his new role, Boudreau will use his extensive experience with ...
(Date:6/5/2020)... ... June 04, 2020 , ... “Although we are disappointed to have ... our attendees, staff, and the public. We remain committed to creating a global ... collaborate virtually,” said Julie Sutcliffe, President of WMIS. , The abstract ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... WESTMINSTER, Colo. (PRWEB) , ... ... ... providers of expert tissue data insights, today announced that the launch of ... PD-L1 results along with data about the tumor microenvironment (TME). , “Flagship’s ...
(Date:6/28/2020)... ... June 25, 2020 , ... With the COVID-19 pandemic ... drug treatment. In an effort to better understand the cellular responses to COVID-19, ... imaging dataset portraying therapeutic compound effects from over 1,600 approved and referenced molecules ...
(Date:6/28/2020)... ... 26, 2020 , ... The Security Industry Association ... opposition to the recently introduced bicameral Facial Recognition and Biometric Technology Moratorium ... use of nearly all biometric and related image analytics technologies, incorrectly labeling all ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... indoor environments, announced today that Derek Fournier has been appointed CEO and President. ... the Board, effective immediately. , “DeCurtis Corporation has been on an incredible ...
Breaking Biology Technology:
Cached News: