HOME >> BIOLOGY >> NEWS
Findings offer clue to how molecule can both stimulate, suppress cell growth

Scientists are puzzled by the fact that the molecule known as transforming growth factor-beta (TGF-b) generally stops cells from multiplying but at other times promotes cell growth.

Dr. Hal Moses, director of the Vanderbilt-Ingram Cancer Center, and his lab identified TGF-b in 1985 as both a growth stimulator and growth suppressor. Since that time, its role in colon, breast and other cancers has been studied extensively at Vanderbilt and elsewhere.

Now a team of researchers at Vanderbilt-Ingram has found a clue to the seemingly contradictory biological actions of TGF-b. Their findings are published online this week by the Proceedings of the National Academy of Science (www.pnas.org) and is expected to appear in the print version later this month.

"TGF-b usually causes cell growth inhibition; however, many solid tumors over-express TGF-b and the cells aren't inhibited at all in fact, sometimes they grow faster than normal as a result of TGF-b signaling," said Neil A. Bhowmick, Ph.D., assistant professor of Urologic Surgery and senior author on the paper. "Many researchers have studied the ways in which TGF-b suppresses cell growth but not many have examined how it promotes cell growth."

The researchers studied normal cells lines whose growth was inhibited by TGF-b -- the process was working properly as well as cell lines whose growth was stimulated by TGF-b.

TGF-b uses multiple signaling pathways to get its instructions to the cell's nucleus at least four pathways that are known, and there are probably more, Bhowmick said.

In the inhibited cells, the researchers removed particular protein components in one of these known TGF-b signaling pathways called Rho-ROCK. The cells were no longer inhibited and instead began growing again.

Then they did the opposite, adding the protein components to cells whose growth was being stimulated by TGF-b to see if their growth would be arrested again that i
'"/>

Contact: Cynthia Floyd Manley
cynthia.manley@vanderbilt.edu
615-936-5711
Vanderbilt University Medical Center
3-Dec-2003


Page: 1 2

Related biology news :

1. Findings suggest need for new view of p53 cancer proteins interaction with DNA
2. Findings redefine mechanism of action of RNA helicase enzymes
3. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
4. Findings could aid efforts to harness nature for making drugs
5. Findings offer further understanding about growth and development in young male gymnasts
6. Findings in frog oocytes may help study of chromosome physiology
7. Findings aid understanding of neurodegenerative diseases
8. Findings show exceptional longevity runs in families
9. Findings give insight into how colon cells transform into precancerous polyps
10. Findings conclude sustained caffeine intake negates the benefits of creatine supplements
11. Findings link disease specific anitbodies to activation of T cells for the first time

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/11/2019)... (PRWEB) , ... July 11, ... ... the world’s first on-site Legionella DNA test, today announced a partnership with ... hospitality industries. , Through this strategic partnership, LiquiTech will integrate Spartan’s innovative ...
(Date:7/9/2019)... ... July 08, 2019 , ... KMK Consulting, Inc. ... Cambridge, MA. This expansion strengthens KMK’s presence for the sales, support, and delivery ... force effectiveness consulting for the biotechnology corridor. With this expansion, KMK can ...
(Date:6/27/2019)... ... ... Lighting designers from integrated design firm LPA recently earned two ... both engaging and energy efficient lighting systems. , The lighting for the repositioning of ... California earned an IES Illumination Award of Merit in the Energy and Environment category. ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... ... July 08, 2019 , ... Today, at the ... National Corn Growers Association (NCGA) announced the winners of the Consider Corn ... product or process using field corn to produce biobased materials. , “Corn is a ...
(Date:6/26/2019)... ... 26, 2019 , ... Alice Branton today released research results from preclinical trials ... Gluconate, which can prove to be beneficial for treating Hypomagnesemia. , The preclinical trial ... in crystallite size , Over 142% increase in particle size , ...
(Date:6/12/2019)... EGG HARBOR TOWNSHIP, N.J. (PRWEB) , ... June ... ... premier manufacturer of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, ... partnership agreement with Shanghai Zillion has been signed. The agreement will grant exclusive ...
(Date:6/11/2019)... REDWOOD CITY, Calif. (PRWEB) , ... June 10, ... ... (IOPP) today announced IOPP will add 80 of its scientific journals to ... addition of physics-related content to DeepDyve’s continually expanding library of more than 20 ...
Breaking Biology Technology:
Cached News: