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Findings offer clue to how molecule can both stimulate, suppress cell growth

s, if normal TGF-b function would be restored by restoring the pathway. "Lo and behold, that's exactly what happened," Bhowmick said.

The findings suggest that the Rho-ROCK signaling pathway, traditionally known for its involvement in cell differentiation and defining cell shape, plays a key role in TGF-b inhibition of cell growth. "Perhaps inactivation of this pathway is a way that cancer cells override the normal growth-suppressing activity of TGF-b," Bhowmick said.

More work is needed to fully understand the implications, but the findings also suggest a potential target for therapeutic intervention to restore TGF-b's ability to inhibit cell growth, he said.

Bhowmick's co-authors on the paper were Mayshan Ghiassi, Mary Aakre, Kimberly Brown, Vikas Singh and Moses, members of the department of Cancer Biology and the Frances Williams Preston Laboratories, supported by the T.J. Martell Foundation at Vanderbilt-Ingram.


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Contact: Cynthia Floyd Manley
cynthia.manley@vanderbilt.edu
615-936-5711
Vanderbilt University Medical Center
3-Dec-2003


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