HOME >> BIOLOGY >> NEWS
Firefly compound lights up 'protein dance' in living animals

St. Louis, July 29, 2004 -- Radiologists at Washington University School of Medicine in St. Louis have developed a first-of-its-kind noninvasive imaging technique that allows them to watch two proteins interacting in live animals.

The technique genetically fuses proteins of interest with carefully cleaved sections of luciferase, the protein fireflies use to create light. When the target proteins interact, the sections of luciferase come together and create light that can be detected outside the body by a highly sensitive camera.

"Instead of looking at a protein by itself, this technique lets us see when two proteins come together and dance," says David Piwnica-Worms, M.D., Ph.D., professor of molecular biology and pharmacology and of radiology. "Those kinds of interactions are very important for many different processes, and they're also key to developing and evaluating new drugs."

Piwnica-Worms and colleagues demonstrated the technique's feasibility on human proteins that interact in the presence of the antibiotic rapamycin. The research appears today in the online edition of the Proceedings of the National Academy of Sciences and will appear in print in the Aug. 17 issue of the journal.

According to Piwnica-Worms, understanding protein interactions has become much more important to biologists in recent years. "We've learned that the human genetic code only has a fraction of the genes we expected, and as a result it's become clear that the context of protein-to-protein interactions significantly affects what proteins can do," he explains. "That's what lets us get away with so few genes -- the same protein can do different things based on when or where it's used." Scientists have studied these interactions previously in cell cultures and in solutions obtained by carefully opening up cells. Luciferase has been used previously to identify the presence of molecules in the cell and in live animals, but this is the first time
'"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
29-Jul-2004


Page: 1 2 3

Related biology news :

1. Firefly molecule could quickly shed light on how well new drugs work
2. Firefly light illuminates course of herpes infection in mice
3. Summer Science: Firefly Babies Advertise Their Bitter Taste, UD Researchers Say
4. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
5. NJIT chemist speaks Aug. 25 about compound derived from pine tree
6. New compound could give some types of cancer the one-two punch
7. Scientists identify compounds that mimic calorie restriction
8. New compound highly efficacious at reducing human tumour growth
9. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
10. New screening method turns up potential compound for treating anthrax
11. New, non-radioactive screen for antimalarial compounds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... ... August 03, 2020 , ... ... a new partnership with medical equipment manufacturer, Spectrum Solutions, to provide COVID-19 saliva ... strengthen their laboratory supply chain for more than 10 years. Early in the ...
(Date:7/22/2020)... ... 21, 2020 , ... USDM Life Sciences , a ... a new solution to manage regulated workloads on Microsoft Azure. , Regulated biotechnology, ... complies with FDA and global regulations. USDM's new managed service for regulated workloads ...
(Date:7/10/2020)... CHURCH, Va. (PRWEB) , ... July 08, 2020 ... ... The Latest on Cell and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July ... may need a comparability study, but what is the most effective way to ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... Modality ... for free its new white paper – Simulated Transport Methodologies. Regulatory expectations ... biologics licensing application (BLA). In response, Modality Solutions shares an explanation of ...
(Date:7/31/2020)... ... , ... R3 Stem Cell International is now offering patients the opportunity to ... total, patients may choose which extremities they would like treated. , Several studies have ... 2016). At R3 International, umbilical cord tissue is obtained from a lab with a ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been ... webinar will cover the history of eSource, the reasons it did not take off ... wearables, to site source, the industry is moving towards capturing data electronically for clinical ...
(Date:7/18/2020)... ... 16, 2020 , ... “We are thrilled to deliver this new technology to ... of its kind on the market and we were pleased that the IFT jury ... traditional cultured ingredients, creating a natural way to extend the shelf life and improve ...
Breaking Biology Technology:
Cached News: