HOME >> BIOLOGY >> NEWS
First clinical study of new pediatric croup vaccine shows safety, tolerability in adults

Scientists at St. Jude Children's Research Hospital are investigating in adults the use of a vaccine given by nose drops that might ultimately protect children against human parainfluenza virus-type 1 (hPIV-1). This virus is the most common cause of croup, a pediatric respiratory disease that causes almost 30,000 hospitalizations each year and many more emergency room visits.

These findings are published in the current issue of Vaccine.

Successful development of an effective hPIV-1 vaccine would be significant because none is currently available and a vaccine that is given to infants using nose drops would eliminate the discomfort and complications of injections.

Because the vaccine contains a live virus, it should stimulate both antibody and cellular immune responses, which together may provide durable protection from hPIV-1. In cellular immunity, special cells, rather than antibodies, destroy virus-infected cells inside the body.

The vaccine consists of Sendai virus (SeV), a mouse virus that is similar enough to hPIV-1 to act as a vaccine, but different enough to have never been associated with a human disease, according to Karen Slobod, M.D., associate member of the department of Infectious Diseases.

Slobod is the lead author of the Vaccine report.

Pre-clinical studies by the St. Jude team proved that intranasal SeV vaccine can protect against the human croup virus. The results of the study in nine healthy adults demonstrated that the SeV vaccine was safe and well tolerated. None of those vaccinated experienced any significant reactions, such as respiratory symptoms or laboratory abnormalities.

This FDA-approved Phase I trial was initiated in adults as a first step, prior to future testing in children and then infants--the ultimate target population, said Jerry Shenep, M.D., member of the department of Infectious Diseases and a co-author of the paper.

"The St. Jude team based the vaccine on SeV for two reasons," sai
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
23-Aug-2004


Page: 1 2

Related biology news :

1. First glimpse of DNA binding to viral enzyme
2. 2nd media alert First Scientific Conference on Childhood Leukaemia
3. First International Scientific Conference on Childhood Leukaemia
4. First ever standards linking climate change, biodiversity and poverty seek global peer review
5. First genetic comparison of purebred domestic dogs produces surprises
6. First time in the U.S.: Saint Louis University tests third-generation vaccine against smallpox
7. First target for childhood malaria vaccine
8. First study of resveratrol dietary supplement finds effect on breast and prostate cancers unlikely
9. First flavors form a lasting impression
10. STN International launches Derwent World Patents Index First View
11. First DFG research conference in the USA

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
(Date:3/30/2017)...  On April 6-7, 2017, Sequencing.com will host the ... hackathon at Microsoft,s headquarters in Redmond, Washington ... developing health and wellness apps that provide a unique, ... is the first hackathon for personal genomics and ... in the genomics, tech and health industries are sending ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... Oct. 11, 2017  VMS BioMarketing, a leading provider of ... oncology Clinical Nurse Educator (CNE) network, which will launch this ... communication among health care professionals to enhance the patient care ... staff, and other health care professionals to help women who ... ...
(Date:10/11/2017)... Tbilisi, Georgia (PRWEB) , ... October 11, 2017 , ... ... disaster, taking the lives of over 5.5 million people each year. Especially those living ... the greenovative startup Treepex - based in one of the most pollution-affected countries globally ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh ... orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of ... SBT-100 is able to cross the cell membrane and bind intracellular STAT3 and ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give it ... Nanoparticle), a technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). ...
Breaking Biology Technology:
Cached News: