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First clinical study of new pediatric croup vaccine shows safety, tolerability in adults

d Allen Portner, Ph.D., member of the department of Infectious Diseases and a co-author of the paper. "First, it appears likely that this virus will provide immunity against hPIV-1 in infants. Second, despite the fact that children frequently have close contact with mice carrying SeV, there has never been a confirmed case of SeV infection in humans." Using a natural mimic of a human virus follows in the tradition of the world's most successful vaccine, the smallpox vaccine, said Julia Hurwitz, Ph.D. member of the department of Immunology.

"The smallpox vaccine was based on the cowpox virus, which caused only limited skin infection in healthy humans," Hurwitz said. "Yet it provided lifelong protection against smallpox and eradicated this disease from the human population in the 1970s. We hope that SeV will similarly help eradicate hPIV-1 as a cause of childhood croup."


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Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
23-Aug-2004


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