First genetic findings in children and adolescents with obsessive-compulsive disorders

Obsessive-compulsive disorder (OCD) is a severe psychiatric illness. The onset of disease often occurs during childhood. OCD is characterized by recurrent and intrusive thoughts (obsessions), usually accompanied by repetitive behaviours (compulsions), the person feels to be driven to perform, e.g. excessive washing of hands. Insight is generally preserved, thus the patient acknowledges the senseless nature of the symptoms. An extensive body of evidence supports the involvement of genetic components in the pathogenesis of OCD. OCD can be effectively treated with serotonin reuptake inhibitors, thus, it has been suggested that genes involved in the serotonergic system may be involved in the aetiology of this disorder. The University clinic for Child and Adolescent Psychiatry of Wrzburg has investigated the etiology of early onset OCD in both family-based studies and longitudinal studies for many years. These studies demonstrated high prevalence of this disorder in the relatives of OCD patients. This supports the hypothesis that genetic factors play a role in OCD disease etiology.

In the present multicenter study, a positive association was identified between OCD and a sequence variant of a serotonergic receptor gene (A-allele of the 5-HT2A-receptor promoter polymorphism 1438G/A). The association suggests that this genetic phenotype is a risk factor for early onset OCD and may represent either a direct or an indirect influence on development of this disorder. The results also indicate that molecular genetic studies should consider age of onset when investigating disease etiology and risk factors.


Contact: Aimee Midei
Molecular Psychiatry

Page: 1

Related biology news :

1. First glimpse of DNA binding to viral enzyme
2. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
3. 2nd media alert First Scientific Conference on Childhood Leukaemia
4. First International Scientific Conference on Childhood Leukaemia
5. First ever standards linking climate change, biodiversity and poverty seek global peer review
6. First genetic comparison of purebred domestic dogs produces surprises
7. First time in the U.S.: Saint Louis University tests third-generation vaccine against smallpox
8. First target for childhood malaria vaccine
9. First study of resveratrol dietary supplement finds effect on breast and prostate cancers unlikely
10. First flavors form a lasting impression
11. STN International launches Derwent World Patents Index First View

Post Your Comments:

(Date:8/19/2019)... ... August 19, 2019 , ... Since ... use of ultra-thin two dimensional slices which are placed on microscope slides, stained ... complex tissues and complicated features such as vasculature and thus researchers in the ...
(Date:8/15/2019)... ... ... Deep Science Ventures (DSV), a new paradigm for applied science, today announced ... 100 companies over the next 10 years to address the urgent need for new ... was founded to create a better method for launching science companies; one that takes ...
(Date:8/15/2019)... ... , ... Serialization deadlines in the US and European Union ... becomes fully applied in the United States in 2023, pharmaceutical companies are scrutinizing ... most regulations?including the Drug Supply Chain Security Act (DSCSA)?have required minimal system capabilities. ...
Breaking Biology News(10 mins):
(Date:6/18/2019)... ... June 17, 2019 , ... IVERIC bio, ... an agreement for production and manufacturing of GMP-grade adeno-associated virus (AAV) vector for ... dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment of BEST1 related retinal ...
(Date:6/11/2019)... MONTREAL (PRWEB) , ... June 10, 2019 , ... ... growth of its distribution network with the appointment of Biofeedback Tech Ltd ... physiological monitoring systems are an essential part of many therapeutic treatments and clinical ...
(Date:6/11/2019)... Md. and ROANOKE, Va. (PRWEB) , ... June ... ... care optimized for microlearning engagement, and Carilion Clinic, a national leader in opioid ... the latest in virtual care. , Mytonomy recently deployed its virtual ...
(Date:6/6/2019)... (PRWEB) , ... June 05, 2019 , ... WCCT ... and medical device industries, announced today that they will be receiving 3 awards at ... Diego, CA. WCCT received 2 awards in the categories of overall Quality and Compatibility ...
Breaking Biology Technology:
Cached News: