HOME >> BIOLOGY >> NEWS
First genetic findings in children and adolescents with obsessive-compulsive disorders

Obsessive-compulsive disorder (OCD) is a severe psychiatric illness. The onset of disease often occurs during childhood. OCD is characterized by recurrent and intrusive thoughts (obsessions), usually accompanied by repetitive behaviours (compulsions), the person feels to be driven to perform, e.g. excessive washing of hands. Insight is generally preserved, thus the patient acknowledges the senseless nature of the symptoms. An extensive body of evidence supports the involvement of genetic components in the pathogenesis of OCD. OCD can be effectively treated with serotonin reuptake inhibitors, thus, it has been suggested that genes involved in the serotonergic system may be involved in the aetiology of this disorder. The University clinic for Child and Adolescent Psychiatry of Wrzburg has investigated the etiology of early onset OCD in both family-based studies and longitudinal studies for many years. These studies demonstrated high prevalence of this disorder in the relatives of OCD patients. This supports the hypothesis that genetic factors play a role in OCD disease etiology.

In the present multicenter study, a positive association was identified between OCD and a sequence variant of a serotonergic receptor gene (A-allele of the 5-HT2A-receptor promoter polymorphism 1438G/A). The association suggests that this genetic phenotype is a risk factor for early onset OCD and may represent either a direct or an indirect influence on development of this disorder. The results also indicate that molecular genetic studies should consider age of onset when investigating disease etiology and risk factors.


'"/>

Contact: Aimee Midei
molecularpsychiatry@mednet.ucla.edu
310-206-6739
Molecular Psychiatry
16-Dec-2002


Page: 1

Related biology news :

1. First glimpse of DNA binding to viral enzyme
2. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
3. 2nd media alert First Scientific Conference on Childhood Leukaemia
4. First International Scientific Conference on Childhood Leukaemia
5. First ever standards linking climate change, biodiversity and poverty seek global peer review
6. First genetic comparison of purebred domestic dogs produces surprises
7. First time in the U.S.: Saint Louis University tests third-generation vaccine against smallpox
8. First target for childhood malaria vaccine
9. First study of resveratrol dietary supplement finds effect on breast and prostate cancers unlikely
10. First flavors form a lasting impression
11. STN International launches Derwent World Patents Index First View

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/27/2019)... (PRWEB) , ... April 26, ... ... flagship market research study " 2019 Global Assessment Report: The Laboratory Analytical ... product categories is presented in 10 sections that include chromatography, life science ...
(Date:4/25/2019)... ... April 23, 2019 , ... For decades Lifecycle ... Genetics and Animal Health companies. Based on Lifecycle’s evolving customer needs and increased ... To better support these industries, Lifecycle has devoted the necessary resources to expand ...
(Date:4/25/2019)... ... April 24, 2019 , ... In a letter ... a broad collective of 62 individual scientists, bioethicists, and biotechnology executives, including past-presidents ... Cell Therapy (ASGCT), across industry and academia called for collaboration on a binding ...
Breaking Biology News(10 mins):
(Date:5/2/2019)... ... May 02, 2019 , ... Stay on top of current ... and food industries. Access to all webinars is free, so be sure to register ... field! , Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL TRIALS ...
(Date:4/18/2019)... (PRWEB) , ... April 18, 2019 , ... ... fuels, a research team that includes a chemical engineer at Worcester Polytechnic Institute ... microorganism that may make it possible to manufacture isobutanol and other biofuels more ...
(Date:4/10/2019)... ... April 10, 2019 , ... RoosterBio ... multiple agreements to help companies advance their innovations to clinical testing more ... synthetic biology companies that are gene editing therapeutic cells for advanced functionality ...
(Date:4/8/2019)... JORDAN, Utah and BOSTON (PRWEB) , ... April ... ... in delivering cloud-based enterprise-class unified communications and collaboration solutions, announced today the launch ... provides integration to an unprecedented range of business and contact-orientated applications while using ...
Breaking Biology Technology:
Cached News: