HOME >> BIOLOGY >> NEWS
First glimpse of DNA binding to viral enzyme

UPTON, NY -- Scientists at the U.S. Department of Energy's Brookhaven National Laboratory and the Albert Einstein College of Medicine have produced the first molecular-scale images of DNA binding to an adenovirus enzyme -- a step they believe is essential for the virus to cause infection. The images, which appear on the cover of the October 2004 issue of Molecular and Cellular Proteomics, show how binding to DNA may stimulate the enzyme and are already being used to design new antiviral drugs to block this interaction.

"We were quite surprised to see that DNA actually stimulated the activity of the enzyme," said Brookhaven biologist Walter Mangel, a co-author on the paper. "If we can block this interaction, we should be able to prevent the virus from replicating, and thereby thwart infection."

Adenoviruses cause respiratory, gastrointestinal, and eye infections, including highly contagious viral pink eye. Some adenovirus eye infections lead to blindness. Respiratory epidemics of adenovirus are often prevalent on army bases. And in patients with compromised immune systems, such as those infected with human immunodeficiency virus (HIV), an opportunistic adenovirus infection can be deadly.

During infection, adenovirus makes an enzyme called a protease, which cleaves or degrades viral "scaffolding" proteins to complete the maturation of newly synthesized virus particles. Mangel and others have been working to understand all the steps necessary for this enzyme's function, looking for new ways to stop its action and, therefore, block an adenovirus infection (see: http://www.bnl.gov/discover/Spring_04/anti_viral_1.asp).

The scientists didn't expect the viral DNA to bind to the protease, but they figured they should look just to rule out such an interaction. "It was something we had to do, to make sure they did not interact," Mangel said. The discovery that the v
'"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
13-Sep-2004


Page: 1 2 3

Related biology news :

1. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
2. 2nd media alert First Scientific Conference on Childhood Leukaemia
3. First International Scientific Conference on Childhood Leukaemia
4. First ever standards linking climate change, biodiversity and poverty seek global peer review
5. First genetic comparison of purebred domestic dogs produces surprises
6. First time in the U.S.: Saint Louis University tests third-generation vaccine against smallpox
7. First target for childhood malaria vaccine
8. First study of resveratrol dietary supplement finds effect on breast and prostate cancers unlikely
9. First flavors form a lasting impression
10. STN International launches Derwent World Patents Index First View
11. First DFG research conference in the USA

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2019)... ... April 23, 2019 , ... Leak ... for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is pleased to ... Harbor Township, New Jersey. The new facility was custom designed to meet enhanced ...
(Date:4/25/2019)... ... April 23, 2019 , ... In recent years the neurocognitive ... However, in many cases the magnitude of these deficits and the long-term impact ... given neurocognitive effects may impact developmental trajectories, and patients are often so unwell ...
(Date:4/25/2019)... , ... April 24, 2019 , ... ... Services Secretary Alex Azar today, a broad collective of 62 individual scientists, bioethicists, ... American Society of Gene & Cell Therapy (ASGCT), across industry and academia called ...
Breaking Biology News(10 mins):
(Date:4/25/2019)... POWAY, Calif. (PRWEB) , ... April 23, 2019 , ... Frank is an albino, deaf ... who did not want him due to his health issues. Despite his hearing impairment, he ... named Tom, and the two would play all day, every day. As the two grew, ...
(Date:4/15/2019)... ... 2019 , ... Sirrus, Inc., a developer of novel electron-deficient ... to increase production of methylene malonate monomers and oligomers. , The expanded bench ... production facility, which is scheduled to break ground in 2019. “The expanded facility ...
(Date:4/9/2019)... (PRWEB) , ... April 09, 2019 , ... Sonny Bar ... left front limb for approximately two months. After a series of diagnostics, an ... tendon. Sonny’s owner, Alison, researched the injury and found that VetStem Regenerative ...
(Date:4/4/2019)... (PRWEB) , ... April 02, 2019 , ... ... PCR solutions, announced it would be releasing it’s latest field-ready solution for performing ... name Biomeme’s next-gen thermocycler Franklin™ pays homage to Rosland Franklin, an English chemist ...
Breaking Biology Technology:
Cached News: