First step along possible new avenue of cancer researc...( alter the types of interactions highli...)

First step along possible new avenue of cancer research reported

alter the types of interactions highlighted by Dr. Mishra. These mutations could very well look a lot like defects in the protein TGF- beta, but you would never think to look at beta-spectrin, prior to this work. Other the other hand, specifically interrupting the interactions of beta-spectrin in the TGF pathway could represent a new approach to the treatment of cancer and disorders involving the overexpression of TGF- beta."

Co-authors of the paper are Yi Tang, Varalakshmi Katuri, Allen Dillner and Bibhuti Mishra of Georgetown University and Chu-Xia Deng of the Genetics of Development Branch of the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health.

This study was funded by NIH, the Veterans Administration, the Betty and Harry Myerberg Foundation, and the Elisabeth and John Cox Foundation.

'"/>

Contact: Elizabeth McDonald
eem6@georgetown.edu
202-687-5100
Georgetown University Medical Center
3-Feb-2003

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