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First study of children born after in vitro maturation indicates the technique is safe

Madrid, Spain: Children born after female eggs were matured in the laboratory are healthy, according to the first survey of babies born using this technique.

Since 1997 doctors at the Fertility Clinic in Herlev, Denmark, have been helping women to have babies using a technique called in vitro maturation. This involves taking immature oocytes (eggs) from the women's ovaries and maturing them in the laboratory for between 28 and 36 hours. Then the oocytes are fertilised using intracytoplasmic sperm injection (ICSI) and the resulting embryos are transferred to the women's wombs.

IVM is a useful procedure for two groups of women: those who are fertile, with normal cycles, who don't need stimulating hormones to help them to become pregnant, but who are undergoing IVF because their partners have impaired sperm; and for women with polycystic ovarian syndrome[1] who are at an increased risk of developing ovarian hyperstimulation syndrome[2] during IVF hormone treatment.

Between July 1998 and January 2002, 33 children have been born after IVM had been carried out at the Herlev Fertility Clinic. Before then only seven IVM children had been born worldwide. However, until now there has been no evidence to show whether babies born after IVM are healthy and functioning normally an important parameter for the quality of the technique.

Dr Anne Lis Mikkelsen, a consultant at the Fertility Clinic, said: "The advantage of maturing the oocytes in vitro is that you eliminate the risk of ovarian hyperstimulation syndrome. We collect the oocytes from 5-10mm follicles and mature the oocytes in vitro for 28 to 36 hours. In women with a regular cycle we perform IVM to time in with their natural cycle and we don't need to give them any extra hormones. In patients with polycystic ovarian syndrome we perform IVM after a short, three-day stimulation of the ovaries with follicle stimulating hormone. The duration of the treatment is very shor
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Contact: Emma Mason
wordmason@aol.com
44-0-1376-563090
European Society for Human Reproduction and Embryology
30-Jun-2003


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