HOME >> BIOLOGY >> NEWS
First target for childhood malaria vaccine

The discovery of a malaria parasite protein that is associated with the severe childhood form of the disease could save the lives of many thousands of children in sub-Saharan Africa. Anja Jensen and colleagues, reporting in The Journal of Experimental Medicine, suggest that this protein could form the basis of a new vaccine against severe malaria.

The malaria-causing parasite Plasmodium falciparum, which is transmitted by mosquito bite, replicates in human red blood cells, which then burst causing life-threatening fever. Infected red blood cells display parasite proteins on their surface that help the parasite to survive in their human host and cause disease complications.

People who have grown up in regions where malaria is endemic usually develop protective antibodies to these parasite proteins, and symptoms in adults are mild compared with the severe disease seen in young children with no previous exposure. Previous work has indicated that the parasites causing severe disease express a set of proteins that are distinct from those produced by parasites that infect adults. But up to this point, no one had identified any of these proteins.

The authors developed a new method to compare for the first time the proteins that are expressed by two types of P. falciparum that cause severe childhood malaria and less severe adult infection, respectively. They identified one protein that is expressed on the surface of red blood cells during severe childhood malaria but not during adult infections. This protein causes infected red blood cells to stick inside blood vessels, preventing their removal in the spleen.

The study also found that this protein, unlike similar malaria proteins studied, does not vary between malaria parasites from East and West Africa, making it an ideal candidate for a universal vaccine to boost immunity to severe malaria in young children.


'"/>

Contact: Lynette Henry
henryn@rockefeller.edu
212-327-8575
Journal of Experimental Medicine
3-May-2004


Page: 1

Related biology news :

1. First glimpse of DNA binding to viral enzyme
2. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
3. 2nd media alert First Scientific Conference on Childhood Leukaemia
4. First International Scientific Conference on Childhood Leukaemia
5. First ever standards linking climate change, biodiversity and poverty seek global peer review
6. First genetic comparison of purebred domestic dogs produces surprises
7. First time in the U.S.: Saint Louis University tests third-generation vaccine against smallpox
8. First study of resveratrol dietary supplement finds effect on breast and prostate cancers unlikely
9. First flavors form a lasting impression
10. STN International launches Derwent World Patents Index First View
11. First DFG research conference in the USA

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/15/2018)... ... , ... The first ever production picosecond-domain laser with a 785?nm wavelength was ... inks - often the colors most resistant to laser removal. , A clinical trial ... Society for Laser Medicine and Surgery, Inc. (ASLMS) investigated the safety and efficacy of ...
(Date:9/12/2018)... ... September 11, 2018 , ... ... proud to introduce the new ChemXP™ line of high performance secondary containment coatings, ... was developed to provide Tennant Coatings’ elite certified installers with the needed solutions ...
(Date:9/7/2018)... (PRWEB) , ... September 05, 2018 , ... ... Platform for a mAb manufacturing facility late last year, IPS-Integrated Project Services, LLC ... the manufacturing of autologous cell therapies. The iCON solution provides a pre-fabricated modular ...
Breaking Biology News(10 mins):
(Date:8/31/2018)... ... August 29, 2018 , ... A ... University of Southampton and the Institute of Industrial Science, the University of Tokyo, ... dramatically accelerate the exploration and study of hard to reach deep sea ecosystems, ...
(Date:8/29/2018)... ... 2018 , ... Cognition Corporation ®, a software company specializing in medical ... . , Ryan Ward, Director of Engineering at Zimmer Biomet, has been announced ... and manager with Zimmer Biomet for almost 15 years, Mr. Ward will focus his ...
(Date:8/29/2018)... ... August 28, 2018 , ... LabRoots , the ... the world, is proud to announce the launch of a new gamification feature, allowing ... chance to win one of LabRoots most popular shirts. , Throughout each month, LabRoots ...
(Date:8/26/2018)... ... August 24, 2018 , ... ExoCoBio Inc., ... dramatically relieves atopic dermatitis and inhibits a variety of inflammatory targets in the ... the symptoms of mice having severe atopic dermatitis were significantly improved after administration ...
Breaking Biology Technology:
Cached News: