Five UCSF faculty scientists elected to National Academy of Sciences

cally engineered product to receive government approval. His research seeks to understand how receptors in the nucleus of a cell affect human health and disease. His focus has been on the function of the thyroid hormone receptor and the use of thyroid hormone-like compounds to treat obesity and cholesterol disorders. He is working on "selective thyroid hormone receptor modulators," or STRMS, that facilitate the beneficial effects of the thyroid hormone while avoiding dangerous side effects.

Cynthia Kenyon studies the genetics of aging. She made international news when she discovered that blocking the activity of a single gene in the roundworm C. elegans doubled the animal's lifespan. The gene, known as daf-2, encodes a receptor for insulin as well as for a hormone called insulin-like growth factor. The same or related hormone pathways have since been shown to affect lifespan in fruit flies and mice, and therefore are likely to control lifespan in humans as well. At UCSF's new Mission Bay campus, she will direct the new Hillblom Center for the Biology of Aging. The center supports research on the biology of aging as well as research programs in diabetes, neurodegenerative diseases and eye disorders.

Robert Stroud seeks to understand molecular mechanisms of key biological processes, as well as the signaling between processes within the cell. His research focuses on how signals cross membranes and how membrane proteins and channels within membranes work at the level of atomic structure. His laboratory also develops methods to quantify the relationship between bonding affinity and molecular structure. Targets for drug design include HIV integrase and drugs to combat resistance in HIV protease.

Arthur Weiss is an authority on the mechanisms by which the immune system's T cells are activated. He is interested in understanding how T cell receptors initiate the cascade of chemical changes that provide the T cell-regulating sig

Contact: Wallace Ravven
University of California - San Francisco

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