HOME >> BIOLOGY >> NEWS
Flare-ups of chronic lung disease associated with specific bacterial strains, UB researchers find

BUFFALO, N.Y. -- University at Buffalo researchers have found an association between bacteria in the sputum of patients with chronic obstructive pulmonary disease (COPD) and exacerbations of the disease, answering a long-standing question about the role of pathogens and COPD flare-ups.

Results of the prospective study appear in the Aug. 15 issue of New England Journal of Medicine. COPD is the fourth-leading cause of death in the U.S., according to the American Lung Association, and fatalities are closely linked to exacerbations. Up to 90 percent of cases of the disease are caused by long-term smoking.

"For years, people have hypothesized that bacteria played a role in COPD exacerbations, but studies performed decades ago found no difference in bacterial presence during stable periods and flare-ups," said Timothy Murphy, M.D., UB professor of medicine and microbiology and senior author on the study.

"Using the new technology of molecular typing, where you can look at turnover of bacteria in the respiratory tract in a more accurate way, we have shown that that hypothesis is correct."

Sanjay Sethi, M.D., UB associate professor of medicine, is first author of the study, which began in 1994. Sethi, Murphy and colleagues found that it is the particular strain within a bacterial species, not the volume of bacteria in general, that is associated with a COPD flare-up. This observation is a change in the way physicians have viewed the role of bacteria in COPD, Murphy noted. The three major pathogens implicated in causing exacerbations were H. influenzae, M. catarrhalis, and Strep. Pneumoniae, the study showed.

In addition to elucidating the role of bacteria in exacerbations, these findings are important because they point to novel ways of treating or preventing exacerbations, Murphy said.

"This information should lead to the development of vaccines to prevent colonization by the offending strains. It also provides a better understandin
'"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
14-Aug-2002


Page: 1 2

Related biology news :

1. Genes appear to play a role in development of chronic obstructive pulmonary disease
2. New research supports theory that indirect transmission of chronic wasting disease
3. Animal studies show promise treating severe chronic pain
4. Researchers show chronic sinusitis is immune disorder; antifungal medicine effective treatment
5. HIV exhausts the immune system through chronic non-specific activation
6. Medical students inadequately prepared for clinical rotations, caring for chronically ill
7. FDA approves Raptiva (efalizumab) for chronic moderate-to-severe plaque psoriasis
8. NIH told regular and moderate exposure to sunlight is the key to preventing chronic disease
9. In men chronically exposed to magnetic fields, no disruptions of melatonin exists
10. Heart drug might help fight chronic fungal infections
11. Hopkins researchers find potential new treatment for children with chronic hepatitis C

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/5/2020)... ... June 04, 2020 , ... Greffex, a pioneering vaccine and ... of Directors. , “Neil understands the need for a global perspective to make an ... of Greffex. Mr. Bush will serve as an independent, director of the company. , ...
(Date:5/28/2020)... ... May 27, 2020 , ... Today bioinformatics leader ... that uniquely combines lab testing insights and hc1’s exclusive Local Risk Index in ... and safety of employees returning to the workplace. , “Some of the best ...
(Date:5/25/2020)... OXFORD, United Kingdom (PRWEB) , ... May 22, 2020 , ... ... test (assay) for the detection of SARS-CoV-2, the virus that causes COVID-19. ... cater to on-demand analysis of smaller sample numbers, to very large numbers of samples. ...
Breaking Biology News(10 mins):
(Date:6/11/2020)... (PRWEB) , ... June 08, 2020 , ... ... universal vaccine platform delivered through the use of proprietary clean viral vectors, recently ... in the United States. Greffex’s platform is the world’s most successful gene ...
(Date:6/3/2020)... ... 03, 2020 , ... Thought Technology Ltd. is offering a ... installment, Dr. Inna Khazan will discuss the benefits of using mindfulness techniques with ... the feelings, thoughts, and emotions they are having in the present moment and ...
(Date:5/28/2020)... ... 28, 2020 , ... Genedata, the leading provider of enterprise ... ® 17.0, the latest version of its enterprise software for the automated analysis, ... will host a webinar on June 10, 2020, detailing and demonstrating the features ...
(Date:5/21/2020)... ... May 19, 2020 , ... Experienced periodontist in Eden Prairie, MN, Dr. Andres ... grafting through PIEZOSURGERY® technology. PIEZOSURGERY uses ultrasonic vibrations to gently cut bone ... patient for dental implants, especially when the implants need to be placed in a ...
Breaking Biology Technology:
Cached News: