HOME >> BIOLOGY >> NEWS
Florida Researchers Discover Gene For Fatal Childhood Disease

GAINESVILLE---University of Florida researchers have identified the gene that causes a rare, fatal childhood disease, according to a report published in Today's issue (7/18) of the journal Nature.

While only 10 to 20 Americans have Chediak-Higashi syndrome, the gene's discovery could have far-reaching implications for tens of thousands of patients who suffer from cancer or autoimmune disorders such as lupus.

Children born with the syndrome have an inherited immune deficiency that weakens their ability to battle bacteria and viruses. They typically die by age 6 of infection or cancer, usually lymphoma or leukemia.

The gene normally acts as a master switch to regulate the transport of proteins within cells, said Dr. Stephen Kingsmore, a molecular geneticist at the Center for Mammalian Genetics at UF's College of Medicine. In Chediak-Higashi syndrome, the gene functions abnormally and many proteins fail to be delivered to their correct destinations within cells.

Scientists also believe this gene plays a role in regulating the spread and development of cancers in general, and in protecting against certain autoimmune disorders.

"This is significant for several reasons. Nobody knew what caused this fatal disease," Kingsmore said. "Now we can design a diagnostic test. And hopefully by understanding the gene we can forge better treatments for Chediak-Higashi syndrome, and in the long run offer genetic therapy for it."

People and mice who have Chediak-Higashi syndrome are much more susceptible to cancer, which spreads faster and more widely than in typical cancer patients, Kingsmore added.

A better understanding of the gene's role in the spread of cancer could lead to new medications or treatments for all cancer patients, he said.

Meanwhile, researchers discovered that mice with Chediak-Higashi syndrome are protected against some forms
'"/>

Contact: Larry Lansford
Larry_Lansford@SFA.UFL.EDU
University of Florida
18-Jul-1996


Page: 1 2

Related biology news :

1. Tracing genes, biologists show lizard migration is traced to Florida
2. Florida Tech earns $50,000 grant to create coral database
3. Florida frontier expedition
4. Florida Tech researchers win $912,700 grant for cell studies
5. Exploring the sights and sounds of a deepwater coral marine protected area off Florida
6. Black water turns the tide on Florida coral
7. UCF to host Florida Academy of Sciences meeting
8. Coral smothering green tide seaweed spreading on Florida reefs
9. University of Florida engineers probe shape memory alloy for better prostheses
10. Common bacteria kills elkhorn coral off Florida keys, says UGA research team
11. University of South Florida team conducts trial for HIV vaccine

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... August 14, 2019 , ... Representatives with MyBioGate announced ... Exhibition Center in Boston. , “We help innovative projects connect with Chinese pharma and ... MyBioGate. , Guo went on to explain that as a part of Biotech Week ...
(Date:8/6/2019)... N.C. (PRWEB) , ... August 06, 2019 , ... ... (SCTM) identifies a computational modeling system that could have far-reaching implications for personalized ... partial least squares regression (PLSR), is able to predict which stem cell donors ...
(Date:8/4/2019)... ... August 02, 2019 , ... Stay on top of ... device and food industries. Access to all webinars is free, so be sure to ... your field! , Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... WORTH, Texas (PRWEB) , ... August 13, 2019 ... ... Fort Collins, Colorado to focus on prepackaged mobile phases for QC laboratories. After ... reinvent Chata from its laboratory sciences approach into a valued supplier of manufacturing ...
(Date:8/6/2019)... ... August 05, 2019 , ... Advanced Clinical, a clinical ... distinguished leader by PharmaVOICE magazine, earning him a prestigious spot on the 2019 ... special issue. , As the executive vice president of business development and marketing ...
(Date:7/23/2019)... WHITEHOUSE, N.J. (PRWEB) , ... July 22, 2019 ... ... pharmaceutical and biotech companies with best-in-class services in the fields of 3D ... and machine learning , Visikol initially started back in 2013 as a ...
(Date:7/17/2019)... ... 16, 2019 , ... Quidel is the market leader in ... Roche and Siemens Healthineers and Response Biomedical also are among the top companies. ... Point-of-Care (POC) Diagnostics . , Quidel is a market leader in rapid immunoassays ...
Breaking Biology Technology:
Cached News: