HOME >> BIOLOGY >> NEWS
Fly Tumor Points Way To New Understanding Of Cancer Development

February 1, 1999-- Howard Hughes Medical Institute (HHMI) researchers at Yale University have "rescued" fruit flies from cancerous tumors by inserting a cancer-suppressing human gene into the insects. The scientists believe that their achievement represents the first direct link between human tumor suppressor genes and those found in the fruit fly Drosophila.

More broadly, the experiments demonstrate that even though flies and humans are separated by 800 million years of evolution, the insects can provide important new insights into human cancers, says HHMI investigator Tian Xu at Yale University School of Medicine.

Tumor suppressor genes produce proteins that normally stop cell proliferation. When such genes malfunction, they produce defective proteins that permit cells to proliferate endlessly, producing tumors.

In a paper published in the February 1999 issue of the journal Nature Genetics, the researchers showed that inserting the human "large tumor suppressor" (LATS1) gene into Drosophila that lacked the fly version of the gene (lats) prevented tumor formation. Flies with the human LATS1 gene did not show the widespread tumors and early mortality caused by the non-functioning lats gene, suggesting that the two genes have the same function.

In addition, Xu and his colleagues uncovered evidence that lats is a new kind of tumor suppressor that blocks a specific stage of cell proliferation. "We believe this finding represents a major advance in understanding cell cycle regulation, and thus cancer biology, because these LATS molecules are a new type of negative regulator for the enzymes that drive the cell cycle," said Xu. Thus, he said, the finding hints that further explorations into the molecular signaling machinery involving LATS1 may yield insights into little-understood cancers and perhaps lead
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
1-Feb-1999


Page: 1 2 3

Related biology news :

1. Tumor cell-specific therapy shows preclinical promise
2. Tumor cells made more sensitive to radiation by blocking a key cellular molecule
3. Discovery Of 13 Genes Expressed In Brain Tumors May Lead To More Effective Diagnosis Or Prevention
4. Dietary Lutein Inhibits Mammary Tumor Growth And Normalizes Immune Balance In Tumor-Bearing Mice
5. Tumor Oxygen Level And Blood Flow Fluctuate, Duke Scientists Discover
6. Vion Demonstrates Readiness Of First Tumor-Targeting Salmonella For Human Testing Against Solid Tumors
7. Compounds From Fruits, Vegetables And Grains Slow The Growth Of Human Tumor Cells
8. New Cell Isolation Method Will Aid In Studying Tumor Development
9. Wistar Institute To Host 3rd International Conference On Molecular And Clinical Genetics Of Childhood Renal Tumors And The Mitchell Ross Symposium
10. Scientists Study Proteins Role In Tumor Development In Fish
11. Vions TAPET Organisms Demonstrate Reduced Virulence, Increased Safety While Retaining Ability To Specifically Target Tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... 5, 2017 Today HYPR Corp. , ... server component of the HYPR platform is officially ... end-to-end security architecture that empowers biometric authentication across Fortune ... already secured over 15 million users across the financial ... connected home product suites and physical access represent a ...
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... the prestigious international IAIR Award for the most innovative high security ePassport ... ... Maldives Immigration Controller General, Mr. ... on the right) have received the IAIR award for the "Most innovative ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... in its endogenous context, enabling overexpression experiments and avoiding the use of exogenous ... RNA guides is transformative for performing systematic gain-of-function studies. , This complement ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 ... London (ICR) and University of ... prognostic tool to risk-stratify patients with multiple myeloma (MM), in ... nine . The University of Leeds ... by Myeloma UK, and ICR will perform the testing services ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive ... a technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). ...
(Date:10/10/2017)... ... 10, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer Jaye ... GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to achieving ...
Breaking Biology Technology:
Cached News: