HOME >> BIOLOGY >> NEWS
Fly cells on the move may reveal clues to cancer metastases

Using neat genetic tricks with fruit flies, scientists from Johns Hopkins School of Medicine have found the key signal that allows a group of normally stationary cells in the ovary to travel, they report in the current issue of Cell.

Because fruit fly genetics are similar to but vastly simpler than human genetics, understanding the signals that mobilize the ovary cells may help clarify how human cancer cells invade distant tissues, says Denise Montell, Ph.D., associate professor of biological chemistry in the school's Institute for Basic Biomedical Sciences.

"Cells usually hold on to their neighbors, so a lot of things have to change for a cell to become migratory," says Montell, who has been studying this process in flies for 12 years. "We've now found the first signal that seems to be sufficient to get cells moving."

With funding from the American Cancer Society and the National Institutes of Health, graduate student Debra Silver examined thousands of mutant fruit flies and identified a protein called "Unpaired" that activates stationary cells.

The fruit fly ovary consists of about one hundred egg chambers, each made of 16 cells -- 15 "nurse" cells and one oocyte, which becomes the egg -- surrounded by a layer of several hundred epithelial cells. At a certain point in development of the egg, a single small cluster of these epithelial cells detaches from the others and moves from the edge of the egg chamber to the center, sliding between nurse cells and coming to rest at the edge of the oocyte.

The cluster consists of two interior "polar" cells and a covering of four to eight "border" cells. Other researchers have shown that, while key to the migratory process, the polar cells can't move without the help of border cells. But until now it wasn't known how polar cells recruit border cells to be their vehicle.

Montell and Silver suspected the polar cells might send an initial, short-range biochem
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
10-Jan-2002


Page: 1 2 3

Related biology news :

1. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
2. Researchers develop fast track way to discover how cells are regulated
3. Chemical signals health of brain cells Symposium
4. New dye directly reveals activated proteins in living cells
5. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
6. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
7. Smac-ing back at cancer cells
8. Bone marrow cells routinely help with wound healing
9. Genuine stem cells found in skin might treat hair loss, wounds
10. Skin stem cells give hairless mice hair
11. Small, Smac-like molecule encourages death of cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/1/2020)... ... 30, 2020 , ... USARAD Holdings Inc., the leading US ... firms announces an official launch of CareDoctors.com. In an effort to help the ... by offering live video consultations with board certified physicians in all specialties in ...
(Date:4/30/2020)... WESTBURY, N.Y. (PRWEB) , ... April 28, 2020 ... ... clients, these webinars are Lachman Consultants latest effort in providing timely and critical ... environment, further complicated by social distancing and health safety concerns. , “Providing the ...
(Date:4/23/2020)... Wis. (PRWEB) , ... April 23, 2020 , ... ... its expansion and recruitment plans. MDG provides critical infrastructure products for the animal ... push MDG’s previous plans for expansion. Further, as supply channels from overseas competitors ...
Breaking Biology News(10 mins):
(Date:4/22/2020)... ... April 21, 2020 , ... ... for determination of FXIII. , Aniara Diagnostica, a multi-national distributor of diagnostic and ... today’s highest standards for product quality and cost-efficient delivery. , For ...
(Date:4/7/2020)... Calif. (PRWEB) , ... April 06, 2020 , ... ... their future children, reached 200,000 SneakPeek Early Gender DNA Tests sold in ... SneakPeek was launched as an ecommerce product, where a mom could order her ...
(Date:4/1/2020)... , ... March 30, 2020 , ... ... telehealth developer Reliant Immune Diagnostics (RID), formed earlier this year to bring telehealth ... by creating in-home tests for COVID-19. Company officials are currently?awaiting an Emergency Use ...
(Date:4/1/2020)... ... March 31, 2020 , ... Bedoukian ... signing of a Joint Development Agreement that builds on each company’s expertise in ... global leader in the supply of high-quality insect pheromones as well as flavors ...
Breaking Biology Technology:
Cached News: