HOME >> BIOLOGY >> NEWS
Folding@home scientists report first distributed computing success

it takes the average computer one day just to do a one-nanosecond [billionth-of-a-second] folding simulation."

Simulating protein folding is often considered a "holy grail" of computational biology, he added. "This is an area of hot competition that includes a number of heavy weights, such as IBM's $100-million, million-processor Blue Gene supercomputer project."

Folding@home

Two years ago, Pande launched Folding@home a distributed computing project that so far has enlisted the aid of more than 200,000 PC owners, whose screensavers are dedicated to simulating the protein-folding process.

The Stanford project operates on principles similar to earlier projects, such as SETI@home, which allows anyone with an Internet connection to search for intelligent life in the universe by downloading special data-analysis software. When a SETI@home screensaver is activated, the PC begins processing packets of radio telescope data. Completed packets are sent back to a central computer, and new ones are assigned automatically.

For the Nature study, Pande and Snow a biophysics graduate student asked volunteer PCs to resolve the folding dynamics of two mutant forms of a tiny protein called BBA5. Each computer was assigned a specific simulation pattern based on its speed.

With 30,000 computers at their disposal, Pande and Snow were able to perform 32,500 folding simulations and accumulate 700 microseconds of folding data. These simulations tested the folding rate of the protein on a 5-, 10- and 20-nanosecond timescale under different temperatures. Using these data, the scientists were able to predict the folding rate and trajectory of the "average" molecule.

Experimental verification

To confirm their predictions, the Stanford team asked Gruebele and Nguyen to conduct "laser temperature-jump experiments" at their Illinois lab. In this technique, an unfolded protein is pulsed with a laser, which heats the molecule just en
'"/>

Contact: Mark Shwartz
mshwartz@stanford.edu
650-723-9296
Stanford University
21-Oct-2002


Page: 1 2 3

Related biology news :

1. DNA lends scientists a hand, revealing new chemical reactions
2. Conference at UH opens doors for new scientists, engineers
3. Wisconsin scientists develop quick botox test
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Alaska scientists find Arctic tundra yields surprising carbon loss
6. UAF scientists discover new marine habitat in Alaska
7. Information system to help scientists analyze mechanisms of social behavior
8. Zoonotic diseases - European scientists unite to fight diseases
9. Israeli scientists reveal the plan of a key cellular machine
10. Study by Israeli scientists provides insight on DNA code
11. Computer scientists at UH developing nurturing computers

Post Your Comments:
(Date:7/23/2014)... around the world have no access to clean drinking ... million people die from water-related diseases every year. ETH ... a contribution to solving this problem. Working with researchers ... the Functional Materials Laboratory, the 23-year-old spent a year ... "What makes our DrinkPure filter unique is that you ...
(Date:7/23/2014)... Non-biting blow fly Chrysomya megacephala is commonly ... investigations to determine the time of death, referred to ... derived form of C. megacephala from Tamil ... morphological features and molecular characterization through generation of DNA ... in the open access Biodiversity Data Journal . ...
(Date:7/23/2014)... with ever-growing piles of electronic waste (or "e-waste"), scientists ... there is and where it really ends up. Published ... , their study found that nearly a quarter of ... developing countries with major potential health risks for ... colleagues note that the export from developed to developing ...
Breaking Biology News(10 mins):ETH student develops filter for clean water around the world 2Dead body feeding larvae useful in forensic investigations 2
(Date:7/23/2014)... July 23, 2014 regulated information -- UCB today ... development pipeline with positive topline results from the ... study was designed to evaluate the efficacy and ... mg/day, without titration) compared to placebo, as adjunctive ... seizures, not fully controlled despite treatment with one ...
(Date:7/23/2014)... -- China Cord Blood Corporation (NYSE: CO ) ("CCBC" ... cord blood collection, laboratory testing, hematopoietic stem cell processing, and stem ... company catering to the mother and child segment, today announced that ... PRC, Singapore , Hong Kong ... the Philippines and Malaysia ...
(Date:7/23/2014)... Adult stem cells that are ... but not magical. However, many current regenerative ... as if they were magical. , Many current ... constitute “stem cell tourism,” are evaluating heterologous tissue ... new regenerative medicine therapies. In reality, these are ...
(Date:7/22/2014)... D.C., June 22, 2014 Even within a phylum so ... is distinguished among other arthropods for its cruelty -- at ... Central America, the fly is a most predatory sort of ... cricket, deposits a smear of larvae, and leaves its wicked ... out. , None of this would be possible without ...
Breaking Biology Technology:Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 4Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 5Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 7China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 2China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 3China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 4The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 2The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 3The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 4The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 5Fly-inspired sound detector 2Fly-inspired sound detector 3Fly-inspired sound detector 4
Cached News: